Results 191 to 200 of about 69,635 (218)

Fouling‐Free Inertial Microfluidic Cell Clarification for Lentivirus Manufacturing

open access: yesBiotechnology and Bioengineering, EarlyView.
ABSTRACT Lentiviral vectors (LVVs) are widely used as gene‐delivery vehicles in cell and gene therapy, enabling stable integration of transgenes into target cells. However, efficient clarification of LVV harvest remains a major bottleneck in large‐scale manufacturing, as conventional depth filtration often results in significant product loss.
Dohyun Park   +5 more
wiley   +1 more source

A General Workflow for Tangential Flow Filtration Perfusion Scale‐Up

open access: yesBiotechnology and Bioengineering, EarlyView.
ABSTRACT Tangential flow filtration (TFF) perfusion using hollow‐fiber modules offers substantial advantages over other mammalian cell retention technologies. Recently, increased awareness of Starling flow has helped to enhance filtration performance to similar, or even higher levels compared to alternative technologies.
Patrick Romann   +20 more
wiley   +1 more source
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