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PHARMACOKINETICS OF HALOGENATED HYDROCARBONS
Annals of the New York Academy of Sciences, 1979Pharmacokinetic modeling is being applied to chemicals posing health hazards because of their presence as contaminants in our environment. This paper presents a rationale for constructing mathematical models based on anatomic and physiological principles.
P M, Bungay, R L, Dedrick, H B, Matthews
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Bioactivation of halogenated hydrocarbons
Journal of Toxicology: Clinical Toxicology, 1982Halogenated hydrocarbons are an economically and toxicologically important group of chemicals. These compounds may produce toxic effects after metabolism to stable, but toxic, products or to reactive, electrophilic intermediates. The biotransformation reaction may involve oxidative or reductive reactions or may proceed with no change in oxidation state.
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