Results 171 to 180 of about 533,861 (287)

T Cell Exhaustion in Cancer Immunotherapy: Heterogeneity, Mechanisms, and Therapeutic Opportunities

Advanced Science, EarlyView.
T cell exhaustion limits immunotherapy efficacy. This article delineates its progression from stem‐like to terminally exhausted states, governed by persistent antigen, transcription factors, epigenetics, and metabolism. It maps the exhaustion landscape in the TME and proposes integrated reversal strategies, providing a translational roadmap to overcome
Yang Yu, Xiaoyu Yao, Qingyang Wang, Mengrui Yang, Runze Li, Jiangjiang Qin, Jing Zhuang, Changgang Sun   +7 more
wiley   +1 more source

Enrichment hydrocarbon‑degrading bacterial communities from the southern Gulf of Mexico in long‑term stored sediments. [PDF]

Biodegradation
Godoy-Lozano EE, Raggi L, Escobar-Zepeda A, Adaya L, Cuervo-Amaya DH, Gracia A, Sanchez-Flores A, Díaz-Camino C, Pardo-López L.   +8 more
europepmc   +1 more source

Immune Checkpoint Inhibitors and Immunomodulators for Cancer Immunotherapy: Insights Into Resistance and Therapeutic Strategies

Advanced Science, EarlyView.
The schematic diagram illustrates the roles of novel immune checkpoints, immunomodulatory factors, cell death and multimodal technologies in cancer immunotherapy. Abstract Cancer immunotherapy has redefined cancer treatment. However, the molecular and cellular basis of immune evasion and therapeutic resistance remains incompletely understood.
Fangquan Chen, Yang Yu, Xiutao Cai, Junhao Lin, Ruirui Liang, Rui Kang, Daolin Tang, Jiao Liu   +7 more
wiley   +1 more source

Metabolic Specialization and Synergy in Alkane Degradation By a Microbial Consortium: An Integrated Genomic and Geochemical Approach. [PDF]

Curr Microbiol
de Santana Nazaré PGB, de Menezes Neto AA, de Oliveira LA, de Souza Queiroz AF, de Oliveira OMC, Lima DF.   +5 more
europepmc   +1 more source

Atomic Tuning of Metal‐Support Interactions for Pathway‐Selective CO2 Photoreduction on TiO2

Advanced Science, EarlyView.
Single‐atom Fe and Cu catalysts anchored on TiO2 steer photocatalytic CO2 reduction toward distinct pathways. Fe sites favor rapid *CO desorption and selective CO formation, whereas Cu sites stabilize *CHO intermediates, enabling deep reduction and C─C coupling. Combined spectroscopy and DFT calculations reveal how metal–support interactions and oxygen
Dongyun Kim, Wonjae Ko, Byoung‐Hoon Lee, Sanghoon Kim, Yun Do Kim, Hyunsoo Ahn, Yoon Jung, Chan Woo Lee, Kug‐Seung Lee, Eunhee Gong, Junho Lee, Minho Kim, Taeghwan Hyeon, Su‐Il In   +13 more
wiley   +1 more source

Hydrothermal transformation of kerogen and oil in Low-permeability rocks of the domanic deposits in carbon dioxide media. [PDF]

Sci Rep
Mikhailova A, Ammar AK, Saeed SA, Suwaid MA, Morozov VP, Feoktistov D, Krivoshapkina E.   +6 more
europepmc   +1 more source

Chemically Engineered L. reuteri Delivering αPD‐L1 and Gallium Ions via Metal‐Phenolic Networks Potentiate Anti‐Tumor Immunity and Ferroptosis

Advanced Science, EarlyView.
A multifaceted chemical strategy, integrating bacterial tropism, metal‐ion interference therapy, and immunotherapy, resulted in significant tumor regression in murine models. A pioneering paradigm for the design of biohybrid materials was established, highlighting how sophisticated chemical engineering of living systems can unlock new avenues for ...
Tingting Zhang, Mengyi Xu, Yan Zhang, Zhiwen Li, Danqing Song, Jing Pang, Ke Li, Yanxiang Wang   +7 more
wiley   +1 more source

Insight into Pyrolysis Behavior and Cross-Linking Reactions Mechanism During Coking Coals Pyrolysis. [PDF]

Materials (Basel)
Tian L, Dou J, Chen X, Yu J.
europepmc   +1 more source

Ultrasoft Yet Tough Multifunctional Organohydrogels Enabled by Molecular Chain Lubrication Strategy for Self‐Powered Wearable Electronics

Advanced Science, EarlyView.
An ultrasoft yet tough organohydrogel (AQGL) with 5800% stretchability and 14.3 kPa modulus is developed via a novel molecular chain lubrication strategy. It features optical transparency, drying/freezing (−40°C) tolerance, antibacterial activity, conductivity, self‐healing, and adhesiveness.
Si Wang, Lin Hu, Mingbo Pu, Mingfeng Xu, Tao Zhou, Hanbing Rao, Xiong Li, Xiaoliang Ma, Gehong Su, Xiangang Luo   +9 more
wiley   +1 more source

Dynamic Evolution of Aroma Characteristics in Ripened Pu-Erh Tea During Industrial Fermentation: Insights from GC-MS and Flavor Wheel Analysis. [PDF]

Foods
Guan Y, Chen Q, Bo N, Yang D, Yang F, Gao H, Tao X, Liang P, Pan G, Cai B, Zhou Y, Zhang H, Peng S, Shi L, Wang T.   +14 more
europepmc   +1 more source