Results 181 to 190 of about 59,000 (265)

Multiscale Analysis of the Impact of the Isomerization of 4-Amine Tetraortho-Azobenzenes on the Structure and Dynamics of Tubular Micelles. [PDF]

open access: yesLangmuir
Luviano AS   +5 more
europepmc   +1 more source

Water‐Enabled Ultralong Full‐Color Organic Phosphorescence in Hydrogen‐Bonded Frameworks for 4D Encryption and Bio‐Imaging

open access: yesAdvanced Science, EarlyView.
Water‐induced quenching challenges organic RTP materials, but a counter‐intuitive strategy employs HOF to encapsulate carbonyl guests, where water functions as a structural reinforcer. This achieves water‐enhanced ultralong RTP with full‐color emission (blue to deep red), overcoming intracellular quenching for high‐signal cellular imaging, alongside 4D
Pengcheng Wu   +3 more
wiley   +1 more source

Membrane Fusion‐Mediated Cytosolic Delivery of Threose Nucleic Acids via Homotypic Nanoparticles Overcomes Drug Resistance in Triple‐Negative Breast Cancer

open access: yesAdvanced Science, EarlyView.
This study introduces a biomimetic “nanofusion” platform that integrates the biostability of threose nucleic acids (TNA) with homotypic cell‐membrane cloaking to combat drug‐resistant TNBC. By leveraging a non‐canonical membrane‐fusion pathway for direct cytosolic delivery, the platform bypasses endosomal sequestration. To achieve potent AKT2 silencing
Wei Zheng   +7 more
wiley   +1 more source

A Biomimetic Dual‐Targeting Nano‐APA‐Editor Reprograms the 3'UTR Landscape for Tongue Squamous Cell Carcinoma Therapy

open access: yesAdvanced Science, EarlyView.
This study unveils a pathogenic axis in oral cancer where NUDT21 suppresses a tumor suppressor network, prominently PTEN, via 3'UTR lengthening. To exploit this transcriptomic vulnerability, we developed a biomimetic Nano‐APA‐editor. By delivering CRISPR/Cas9, we reprogrammed the global 3'UTR landscape, restoring multi‐target tumor suppression and ...
Yiran Ao   +5 more
wiley   +1 more source

Photothermal Amplification via Nanorobotic Swarming Dynamics

open access: yesAdvanced Science, EarlyView.
This study explores a novel approach to enhance photothermal therapy using magnetically regulated microswarms. It details the development of magnetic nanoparticles organized into dynamic structures that improve heat retention and conversion efficiency.
Qinglong Wang   +8 more
wiley   +1 more source

Ultrasound‐Activatable Piezoelectric Hydrogel Reprograms Mitochondrial Epigenetics for Osteoarthritis Therapy via the mTOR/GATD3A Axis

open access: yesAdvanced Science, EarlyView.
An ultrasound‐activatable piezoelectric hydrogel reprograms chondrocyte mitochondrial epigenetics via the mTOR/GATD3A axis, clearing damaged mitochondria and alleviating osteoarthritis progression in both mouse models and human cartilage explants. ABSTRACT The avascular nature of cartilage hinders drug delivery for osteoarthritis (OA) therapy.
Hui Zheng   +9 more
wiley   +1 more source

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