Results 51 to 60 of about 20,748 (263)

Overcoming Photodynamic Therapy Resistance: GSH‐Responsive AIE Photosensitizer‐Hydroxycamptothecin Nanoliposomes for Extrahepatic Cholangiocarcinoma

Advanced Healthcare Materials, EarlyView.
A GSH‐responsive AIE nanoplatform (TSH NPs) with RGD‐mediated tumor targeting co‐delivers a photosensitizer (TPA) and HCPT for extrahepatic cholangiocarcinoma. The system synergistically enhances PDT and chemotherapy by suppressing HIF‐1α/VEGF‐driven hypoxic adaptation, effectively overcoming PDT resistance.
Yong Qu, Tao Peng, Yating Zhang, Juanmei Cao, Birong Wang, Chuxing Chai, Zhiyuan Gao, Yiting Xu, Yifan Jin, Yuqing Wang, Zhuoxia Li, Xu Liu, Tianqi Zhao, Yufan Chen, Weimin Lv, Di Lu, Changzheng Huang, Dan Ding, Jinxiang Zhang, Min Li   +19 more
wiley   +1 more source

Estimation of Specific Storage and Transmissivity Coefficients for the Hamadan-Bahar Plain Aquifers Using the Stepwise- Balance Method [PDF]

مهندسی منابع آب, 2015
Specific Storage (Sy) and transmissivity (T) are two of the highly important hydrodynamic parameters required in estimation of the aquifer storage capacity and groundwater (GW) flow through the saturated zone to wells, qantas, springs, **   Water storage
پگاه رئوفی منش, نجم الدین واصلی, محمودرضا شقاقیان   +2 more
doaj  

Lignin Mimicking Protein Methylation Augments the Efficacy of FOLFOX Chemotherapy by Anchoring Thymidylate Synthase

Advanced Materials, EarlyView.
Lignin‐mimicking protein methylation can enhance the efficacy and mitigate the toxicity of the classic FOLFOX chemotherapy regimen. ABSTRACT FOLFOX has served as the standard chemotherapy regimen for advanced stages, specifically in the treatment of pancreatic, colorectal, and bladder cancers.
Shiyao Song, Yan‐Lai Tang, Xiaoting Liu, Jiayi Zheng, Chong Wu, Tang Li, Junhong Ye, Dianmin Xia, Yong Mei, Jingxuan Ma, Libin Huang, Xuequn Luo, Liheng Chen, Yanlin Qin, Weiling He   +14 more
wiley   +1 more source

Mechanism‐Driven Nanoformulations for Cognitive Impairment Induced by Intermittent Hypoxia and Periodontitis

Advanced Materials, EarlyView.
Clinically, intermittent hypoxia (IH) is often accompanied by periodontitis, which accelerates cognitive impairment induced by IH. Novel Janus mesoporous gold‐silica nanoformulations (RVG‐Au&mSiO2‐TPP‐VB) enable intranasal delivery, achieve hierarchical targeting to neuronal mitochondria, effectively scavenge reactive oxygen species, inhibit the HIF‐1α/
Kai‐Run Zhang, Tianbao Zhu, An‐Qi Liu, Jia‐Jia Deng, Ya‐Li Han, Sheng‐Cai Qi, Xue Liu, Tian‐Yi Jiang, Ming‐Rui Zhai, Yu‐Ying He, Xiu‐Juan Li, Hong‐Ting Da, Rui Xu, Xiaomin Li, Jun Gao, Yue‐Hua Liu   +15 more
wiley   +1 more source

Numerical simulation of hydrodynamics of ocean-observation-used remotely operated vehicle

Frontiers in Marine Science
Remotely operated vehicle is the most widely used underwater robot and can work safely and steadily in complex environments compared to autonomous underwater vehicle and other types.
Dapeng Zhang, Bowen Zhao, Yi Zhang, Nan Zhou   +3 more
doaj   +1 more source

Application of CFD Methods for the Assessment of Ship Manoeuvrability in Shallow Water [PDF]

TransNav, 2012
Safety in water transport plays a significant role. One way to increase safety in the waterways is to ensure that ships have proper manoeuvrability. Evaluation of manoeuvring properties performed at an early stage of design can detect problems that later
Tomasz Gornicz, Jan Kulczyk
doaj  

Numerical Study on the Hydrodynamic Coefficients and Flow Field Characteristics of Underwater Manipulator [PDF]

Journal of Applied Fluid Mechanics
The hydrodynamic coefficient of an underwater manipulator varies with changes in posture and flow field, presenting significant challenges for precise control and localization.
S. Dai, S. Ren, X. Liu, D. Duan, H. Jin, H. Zhang   +5 more
doaj   +1 more source

Hydrodynamic Transport Coefficients of Granular Gases [PDF]

, 2001
Some transport properties of granular gases are investigated. Starting from a kinetic theory level of description, the hydrodynamic transport equations to Navier-Stokes order are presented. The equations are derived by means of the Chapman-Enskog procedure.
Brey Abalo, José Javier, Cubero Gómez, David   +1 more
openaire   +3 more sources

Prediction of resistance coefficients in ship hydrodynamics [PDF]

Journal of Marine Science and Technology, 2009
The conference MARINE2007 was held in June 2007 in Barcelona, Spain, as the second in a series of thematic conferences, Computational Methods in Marine Engineering, organized by the European Community on Computational Methods in Applied Sciences (ECCOMAS) starting in 2005.
Luís Eça, Michel Visonneau, Yoshiaki Kodama   +2 more
openaire   +1 more source

Resolving Heterogeneity of Targeted Lipid Nanoparticles Through Solution‐Based Biophysical Analyses

Advanced Materials, EarlyView.
AF4‐UV‐DLS‐MALS‐SAXS resolves previously inaccessible targeted lipid nanoparticle (tLNP) subpopulations that differ in size, shape, and composition. Correlation of subpopulation‐resolved biophysical properties with in vivo RNA delivery reveals that targeted placental transfection is associated with distinct tLNP subpopulations rather than ensemble ...
Hannah C. Geisler, Hannah C. Safford, Ajay S. Thatte, Marshall S. Padilla, Elisa Battistini, Hannah M. Yamagata, Violet M. Ullman, Alex Chan, Benjamin E. Nachod, Anushka Agrawal, Maxwell B. Watkins, Jesse B. Hopkins, Andrew Tsourkas, Kushol Gupta, Michael J. Mitchell   +14 more
wiley   +1 more source