Results 51 to 60 of about 615,749 (292)

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source

(Z)-2-(2-Isopropyl-5-methylphenoxy)-N′-(2-oxoindolin-3-ylidene)acetohydrazide

Acta Crystallographica Section E, 2010
In the title Mannich base, C20H21N3O3, an isatin derivative of thymol, the O—CH2—C(=O)–N(H)—N fragment connecting the aromatic and fused-ring systems is approximately planar, with the N—N single bond in a
Chetan M. Zade, Umesh D. Pete, Amol G. Dikundwar, Ratnamala S. Bendre   +3 more
doaj   +1 more source

dUTPase is essential in zebrafish development and possesses several single‐nucleotide variants with pronounced structural and functional consequences

FEBS Open Bio, EarlyView.
dUTPases are involved in balancing the appropriate nucleotide pools. We showed that dUTPase is essential for normal development in zebrafish. The different zebrafish genomes contain several single‐nucleotide variations (SNPs) of the dut gene. One of the dUTPase variants displayed drastically lower protein stability and catalytic efficiency as compared ...
Viktória Perey‐Simon, Angéla Békesi, Latifa Kazzazy, Jázmin Mihály, Máté Varga, Beáta G. Vértessy, Kinga Nyíri   +6 more
wiley   +1 more source

Chlorido(4-methylpyridin-2-amine-κN1)(2-{[(4-methylpyridin-2-yl)imino-κN]methyl}phenolato-κO)copper(II)

Acta Crystallographica Section E, 2012
In the title complex, [Cu(C13H11N2O)Cl(C6H8N2)], the CuII atom adopts a distorted tetrahedral geometry being coordinated by the phenolic O atom and the azomethine N atom of the Schiff base ligand N-salicylidene 2-aminopyridine, and by the 2-aminopyridine
Bussa Bhagyaraju, P. Sambasiva Rao, Toka Swu   +2 more
doaj   +1 more source

Hydrogen atom in phase space. The Kirkwood-Rihaczek representation [PDF]

, 2002
We present a phase-space representation of the hydrogen atom using the Kirkwood-Rikaczek distribution function. This distribution allows us to obtain analytical results, which is quite unique because an exact analytical form of the Wigner functions ...
A. N. Rihaczek, E. C. G. Sudarshan, E. Wigner, J. G. Kirkwood, J. P. Dahl, J. P. Dahl, K. Cahill, K. Cahill, K. Husimi, K. Takahashi, K. Wódkiewicz, L. Praxmeyer, M. Springborg, R. J. Glauber, R. O’Connell, S. Nouri   +15 more
core   +2 more sources

Exon 7 splicing of ERα predicts poor prognosis and increases phenotypic heterogeneity in luminal a subtype breast cancer

FEBS Open Bio, EarlyView.
ERα splice variant ERα∆7 lacks the C‐terminus, and its expression may change phenotypes of breast cancers. Our results showed that ERα∆7 is found in the luminal A subtype, and elevated ERα∆7 levels are linked to improved cell survival with lower proliferation and migration.
Long Wai Tsui, Taobo Hu, Thomson Christian Husein, Wai Hei Shek, Bingrong Chen, Depeng Wang, Shu Wang, Weichuan Yu, Xiaodan Fan, Mengping Long, Toyotaka Ishibashi   +10 more
wiley   +1 more source

1-(5,7-Dihydroxy-2,2-dimethylchroman-6-yl)ethanone

Acta Crystallographica Section E, 2011
In the title molecule, C13H16O4, the pyran ring is in a half-chair conformation. There is an intramolecular hydrogen bond involving the ketone O atom and an H atom of a phenol group which forms an S(6) ring.
Matthew P. Akerman, Zimbili Mkhize, Fanie R. van Heerden   +2 more
doaj   +1 more source

The two-dimensional hydrogen atom revisited [PDF]

, 2002
The bound state energy eigenvalues for the two-dimensional Kepler problem are found to be degenerate. This "accidental" degeneracy is due to the existence of a two-dimensional analogue of the quantum-mechanical Runge-Lenz vector.
Alliluev, Aquilanti, Bander, Bander, Bargmann, D. G. W. Parfitt, Daboul, Daboul, Fock, M. E. Portnoi, Pauli, Yang, Yang   +12 more
core   +2 more sources

Evolutionarily divergent DUF4465 domains have a common vitamin B12‐binding function

FEBS Open Bio, EarlyView.
We show that DUF4465 family proteins, widespread across bacteria from gut microbiomes, hydrothermal vents, and soil, share a common vitamin B12‐binding function. These augmented β‐jellyroll proteins bind vitamin B12 via extended loops. Our findings establish sequence‐diverse DUF4465 proteins as a widespread class of B12‐binding proteins, highlighting ...
Charlea Clarke, Michal Banasik, Rokas Juodeikis, Martin J. Warren, Richard W. Pickersgill   +4 more
wiley   +1 more source

Atomic hydrogen: the quantum gas [PDF]

Physics World, 1995
It was a complete surprise when Isaac Silvera and his colleagues at the University of Amsterdam observed the existence of a remarkably stable gas of hydrogen atoms in 1979. They found that a gas of the so-called "atom of atoms" could be confined for several minutes in a cryogenic test cell close to absolute zero, provided that the walls were coated ...
openaire   +3 more sources