Results 61 to 70 of about 677,911 (296)
Interpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi +7 more
wiley +1 more source
Hydrogen Energy For Indian Transport Sector - A Well-To-Wheel Techno-Economic and Environmental Feasibility Analysis [PDF]
With the alarming rate of growth in vehicle population and travel demand, the energy consumption has increased significantly contributing to the rise of GHG emissions.
B. Sudhakara Reddy, P. Balachandra
core +1 more source
, 2019 The dominating trend of variable renewable energy sources (RES) continues to underpin the early retirement of baseload power generating sources such as coal, nuclear, and natural gas steam generators; however, the need to maintain system reliability remains the challenge.
openaire +3 more sources
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
Communications EngineeringAlkaline water electrolysers are ideal for gigawatt-scale hydrogen production due to the usage of non-precious metal and low-cost raw materials. However, their performances are modest with the separated electrode and diaphragm structure which can date ...
Zhuang Xu +7 more
doaj +1 more source
Molecular Oncology, EarlyView.BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi +11 more
wiley +1 more source
Scientific Reports, 2022 In this study, a sulfonated poly(ether sulfone) having cardo-type fluorenyl groups (FL-SPES) was investigated as a cathodic binder to improve fuel cell performance via increased the oxygen diffusion in the cathode.
Jung-Eun Cha +5 more
doaj +1 more source
FEBS Open Bio, EarlyView.Unique biological samples, such as site‐specific mutant proteins, are available only in limited quantities. Here, we present a polarization‐resolved transient infrared spectroscopy setup with referencing to improve signal‐to‐noise tailored towards tracing small signals. We provide an overview of characterizing the excitation conditions for polarization‐
Clark Zahn, Karsten Heyne
wiley +1 more source
Nano-Micro LettersHighlights Novel amphiphilic patterned titanium porous transport layers (PTLs) significantly enhance the round-trip efficiency of unitized regenerative fuel cells (URFCs), achieving an impressive round-trip efficiency of 25.7% at a current density of 2 A
Sung Min Lee +4 more
doaj +1 more source
Some harvesting system transforming energy wastes of compressed air to electricity
E3S Web of Conferences, 2017 Energy harvesting devices are self-powered systems which are associated with input ambient energy and convert such energy to electrical one. In this study, we focus on input ambient energy deriving from compressed air.
Leszczynski Jacek S. +9 more
doaj +1 more source