Results 41 to 50 of about 1,328,736 (256)

Leucine‐rich glioma inactivated 1 (LGI1) is a ganglioside‐binding protein

FEBS Letters, EarlyView.
Neuronal hyperexcitability associated with a decrease/absence of the extracellular protein LGI1 has been suggested to be primarily due to the downregulation of Kv1 channel expression. The molecular mechanisms underlying this decrease have not yet been elucidated.
Kévin Debreux, Christian Lévêque, Fodil Azzaz, Marion Sangiardi, Sarosh R Irani, Michael Seagar, Jacques Fantini, Oussama El Far   +7 more
wiley   +1 more source

Hydrogen‐Enriched Tri‐Fuel Combustion for Low‐Carbon Engines at Medium Engine Load: A Comprehensive CFD Analysis

Energy Science & Engineering
The global commitment to achieve net‐zero carbon emissions by 2050 has intensified the growing demand for sustainable and low‐carbon energy systems. Inspired by this vision, hydrogen (H2) has attracted massive attention as a clean and highly reactive ...
Md. Ifthaker Alam, Tafsirul Hassan, Md Imtiaz Hossen, Md. Shaib Hossain, Bandhon Saha Bijoy   +4 more
doaj   +1 more source

Smart polymers driven by multiple and tunable hydrogen bonds for intact phosphoprotein enrichment

Science and Technology of Advanced Materials, 2019
Separation of phosphoproteins is essential for understanding their vital roles in biological processes and pathology. Transition metal-based receptors and antibodies, the routinely used materials for phosphoproteins enrichment, both suffer from low ...
Xiaofei Zhang, Qi Lu, Cheng Chen, Xiuling Li, Guangyan Qing, Taolei Sun, Xinmiao Liang   +6 more
doaj   +1 more source

Membrane composition and thermodynamic identity as boundaries of life for synthetic cell research

FEBS Letters, EarlyView.
What makes a cell a cell? The boundary of a living cell is not just a wall. Read as a Markov blanket, the membrane separates internal from external states, generating identity and non‐equilibrium order. Can this identity be rebuilt from scratch in a synthetic cell?
Caterina Presutti, Bert Poolman
wiley   +1 more source

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

Hydrogen and oxygen fuel enrichment effects on a HD diesel engine [PDF]

, 2017
Implementing emission regulations in the transport sector is enforcing manufacturers to improve performance of Heavy Duty (HD) vehicles as they are accountable for 25% of CO2 emissions within EU.
Monemian, Emad, Cairns, Alasdair, Pedrozo, V.   +2 more
core  

Mutant p53R273H disrupts PDPK1 homodimerization and contributes to PDPK1 activation

Molecular Oncology, EarlyView.
How mutant p53R273H drives AKT signaling is unclear. We show that p53R273H, but not wild‐type, directly binds PDPK1 via a mutation‐dependent conformational change. This interaction disrupts inhibitory PDPK1 homodimerization and enhances AKT phosphorylation.
Mei Chee Lim, Alvin Kunyao Guo, Yoko Itahana, Srinivasaraghavan Kannan, Valerie Goh, Mingmin Ong, Terina Yan Wen Tay, Weiying Ye, Sabhashina Radha Krishnan, Jun Nishiyama, Chandra S Verma, Koji Itahana   +11 more
wiley   +1 more source

A Comprehensive Review on the Hydrogen–Natural Gas–Diesel Tri-Fuel Engine Exhaust Emissions

Energies
Natural gas (NG) is favored for transportation due to its availability and lower CO2 emissions than fossil fuels, despite drawbacks like poor lean combustion ability and slow burning.
Hassan Sadah Muhssen, Máté Zöldy, Ákos Bereczky   +2 more
doaj   +1 more source

Transcripts enriched in codons that trigger P‐site tRNA‐mediated mRNA decay possess stable mRNA

FEBS Open Bio, EarlyView.
PTMD codons were first described by Mendel et al. as mediators of an mRNA decay pathway dependent on the human protein CNOT3, homologous to yeast Not5. Our findings confirm that PTMD codons destabilize transcripts; however, unlike in yeast, the human pathway specifically targets and slightly destabilizes primarily stable mRNAs.
Rodolfo Lopes Carneiro, Fernando Lucas Palhano   +1 more
wiley   +1 more source

Effect of Methane Substitution with Hydrogen in a Dual-Fuel Diesel/Methane Engine with Late Pilot Injection Strategy

Energies
Hydrogen is recognized as a promising energy vector for the decarbonization of energy production. Besides the undoubted benefits, its utilization poses some technological challenges in the generation, transportation, storage and utilization phases, which
Antonio Paolo Carlucci, Luciano Strafella, Antonio Ficarella   +2 more
doaj   +1 more source