Results 71 to 80 of about 405,542 (311)

Effects of different renewable electricity diffusion paths and restricted european cooperation on Europe's hydrogen supply

open access: yesEnergy Strategy Reviews
Today, most hydrogen production is based on natural gas and occurs locally at the demand sites. However, according to many studies, hydrogen generation will shift to greenhouse gas (GHG)-neutral sources and supply, substantially increasing demands to ...
Benjamin Lux   +4 more
doaj   +1 more source

Dual PI3K/AKT and CDK4/6 inhibition reveals selective sensitivity in an SHH medulloblastoma stem cell model

open access: yesMolecular Oncology, EarlyView.
Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute   +4 more
wiley   +1 more source

Capacity optimization of photovoltaic storage hydrogen power generation system with peak shaving and frequency regulation

open access: yesSustainable Energy Research
To solve the problem of power imbalance caused by the large-scale integration of photovoltaic new energy into the power grid, an improved optimization configuration method for the capacity of a hydrogen storage system power generation system used for ...
Dan Yu, Peng Yang, Weijun Zhu
doaj   +1 more source

Multiphysics-Driven Structural Optimization of Flat-Tube Solid Oxide Electrolysis Cells to Enhance Hydrogen Production Efficiency and Thermal Stress Resistance

open access: yesEnergies
The solid oxide electrolysis cell (SOEC) has potential application value in water electrolysis for hydrogen production. Here, we propose an integrated multi-scale optimization framework for the SOEC, addressing critical challenges in microstructure ...
Shanshan Liang   +5 more
doaj   +1 more source

Effects of the Preparation Solvent on the Catalytic Properties of Cobalt–Boron Alloy for the Hydrolysis of Alkaline Sodium Borohydride

open access: yesMetals, 2017
In this study, the effects of the solvent used to prepare Co–B alloy on its catalytic properties were investigated. The solvent effects on the morphology, composition, and specific surface area of the alloy particles were also examined. The morphology of
Yongjin Zou   +8 more
doaj   +1 more source

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

open access: yesMolecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh   +12 more
wiley   +1 more source

Interpreting the effects of DNA polymerase variants at the structural level

open access: yesMolecular Oncology, EarlyView.
Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi   +7 more
wiley   +1 more source

Silver-Assisted Hydrogen Evolution from Aluminum Oxidation in Saline Media

open access: yesMolecules
A swarf of aluminum alloy with high corrosion resistance and ductility was successfully converted into fine hydro reactive powders via ball milling with silver powder and either lithium chloride or gallium. The latter substances significantly intensified
Olesya A. Buryakovskaya   +5 more
doaj   +1 more source

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

open access: yesMolecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura   +19 more
wiley   +1 more source

Home - About - Disclaimer - Privacy