Results 41 to 50 of about 2,001,817 (293)

Targeting TNBC: core–shell polycationic polyurea dendrimers with inherent anticancer activity

FEBS Open Bio, EarlyView.
Core–shell polycationic PURE dendrimers were tested in TNBC‐derived tumor models. Both formulations selectively targeted TNBC and effectively reduced tumor volume. PUREG4‐OEI48 suppressed tumor growth without detectable toxicity, whereas PUREG4‐OCEI24, despite showing efficacy, induced hepatic toxicity.
Adriana Cruz, Bruna Abreu, Cindy Mendes, Catarina Freitas‐Dias, Filipe Gonçalves, Fernanda Silva, José Ramalho, Saudade André, Vasco D. B. Bonifácio, Jacinta Serpa   +9 more
wiley   +1 more source

Suppression of lung adenocarcinoma migration through organelle alkalization by human lactoferrin – albumin fusion

FEBS Open Bio, EarlyView.
This paper reveals how human lactoferrin–albumin fusion (hLF‐HSA) potently suppresses lung adenocarcinoma cell migration. hLF‐HSA upregulates NHE7, leading to Golgi alkalization, disruption of the Golgi secretome, downregulation of MMP1, and reversal of EMT. These findings suggest a novel Golgi‐targeting strategy to suppress cancer cell migration.
Hana Nopia, Masahiro Kimura, Daisuke Kurimoto, Atsushi Sato   +3 more
wiley   +1 more source

Characteristics Analysis of Small⁃Hole Jet Leakage of Hydrogen⁃Blended Natural Gas High⁃Pressure Pipeline in Open Space

Shiyou huagong gaodeng xuexiao xuebao
In order to quickly define the dangerous distance of leakage in hydrogen⁃blended natural gas high⁃pressure pipelines, this study established a mathematical model of small hole jet leakage of hydrogen⁃blended natural gas high⁃pressure pipelines in open ...
Haifeng XU, Shilong XUE, Pengfei ZHAO, Xiaobin ZHANG   +3 more
doaj   +1 more source

Epilepsy‐Associated Variants of a Single SCN1A Codon Exhibit Divergent Functional Properties

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Pathogenic variants in SCN1A, which encodes the voltage‐gated sodium channel NaV1.1, are associated with multiple epilepsy syndromes exhibiting a range of clinical severity. SCN1A variants are reported in different syndromes, including Dravet syndrome, which is associated with loss‐of‐function, whereas neonatal/infantile‐onset ...
Lanie N. Liebovitz, Christopher H. Thompson, Linda C. Laux, Alfred L. George Jr.   +3 more
wiley   +1 more source

Influence of an Argon/Silane Atmosphere on the Temperature of a Thermal Plasma

Advanced Engineering Materials, EarlyView.
The influence of a silane‐doped argon atmosphere on the chemical composition and temperature of a thermal nontransferring argon plasma is investigated using optical emission spectroscopy. As a result of the high amount of free electrons resulting from the stepwise ionization and dissociation of the silane molecule, even a silane addition of 0.01 vol ...
Lena Kreie, David Kramer, Thomas Scheithauer, Hans Jürgen Maier, Thomas Hassel   +4 more
wiley   +1 more source

Molecular mechanisms of hydrogen leakage through caprock in moisture and residual gas conditions: A molecular dynamics–Monte Carlo study

The Physics of Fluids
Underground hydrogen (H2) storage has become increasingly popular in recent years; however, H2 leakage is a critical concern. A conventional reservoir is sealed by a dense caprock; the long-chain hydrocarbons cannot escape through the caprock because of ...
Jie Liu, Tao Zhang, Shuyu Sun
semanticscholar   +1 more source

Modeling of Hydrogen Dispersion, Jet Fires and Explosions Caused by Hydrogen Pipeline Leakage

Fire, 2023
Accidental hydrogen releases from pipelines pose significant risks, particularly with the expanding deployment of hydrogen infrastructure. Despite this, there has been a lack of thorough investigation into hydrogen leakage from pipelines, especially under complex real-world conditions.
Yujie Lin, Xiaodong Ling, Anfeng Yu, Yi Liu, Di Liu, Yazhen Wang, Qian Wu, Yuan Lu   +7 more
openaire   +2 more sources

Handbook of Establishing and Maintaining Oxygen‐Free Atmospheres

Advanced Engineering Materials, EarlyView.
This study presents a practical framework for creating oxygen‐free atmospheres at ambient pressure using silane‐doped inert gases. The results show that ultra‐low oxygen levels and strongly reduced water content can be achieved through controlled silane dosing, drying systems, and sensor monitoring.
Sascha Jan Zimmermann, René Gustus, Lienhard Wegewitz, Wolfgang Maus‐Friedrichs   +3 more
wiley   +1 more source

Influence of Longitudinal Wind on Hydrogen Leakage and Hydrogen Concentration Sensor Layout of Fuel Cell Vehicles

Sustainability, 2023
Hydrogen has the physical and chemical characteristics of being flammable, explosive and prone to leakage, and its safety is the main issue faced by the promotion of hydrogen as an energy source.
Xingmao Wang, Fengyan Yi, Qingqing Su, Jiaming Zhou, Yan Sun, Wei Guo, Xing Shu   +6 more
semanticscholar   +1 more source

Dielectric Barrier Discharge Plasma Deoxidation of Natively Oxide Layer of Copper Powders in a Fluidized Bed

Advanced Engineering Materials, EarlyView.
This paper presents a novel approach to reducing oxide layers on metal powders using low‐temperature hydrogen dielectric barrier discharge plasmas at atmospheric pressure. Unlike conventional hydrogen‐plasma reductions, the powders do not contact the plasma directly.
Shukang Zhang, Annett Wollmann, Thomas Gimpel, Alfred P. Weber   +3 more
wiley   +1 more source