Results 51 to 60 of about 2,229,222 (298)

Interpreting the effects of DNA polymerase variants at the structural level

Molecular Oncology, EarlyView.
Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi, Karolina Krzesińska, Ludovica Beltrame, Pablo Sánchez‐Izquierdo Besora, Matteo Tiberti, Mef Nilbert, Anna Rohlin, Elena Papaleo   +7 more
wiley   +1 more source

Machine learning–based optimization for hydrogen purification performance of layered bed pressure swing adsorption

International Journal of Energy Research, 2020
An adsorption, heat and mass transfer model for the five‐component gas from coal gas (H2/CO2/CH4/CO/N2 = 38/50/1/1/10 vol%) in a layered bed packed with activated carbon and zeolite was established by Aspen Adsorption software.
Jinsheng Xiao, Chenglong Li, Liang Fang, Pascal Böwer, M. Wark, P. Bénard, R. Chahine   +6 more
semanticscholar   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Hydrogen Separation and Purification Techniques in Pyrolysis-Based Processes

ABUAD Journal of Engineering Research and Development
The production of hydrogen via pyrolysis process has gained a significant attention due to its capacity to offer reliable and sustainable as well as efficient techniques for hydrogen energy generation.
Augustine Oluwatoyin Ojo, Bernard Adaramola, Adeniran Sunday Afolalu, Stella Isioma Stella Isioma Monye   +3 more
doaj   +1 more source

Targeting Model of Inter-Plant Hydrogen Network with Purification Reuse/Recycle

Chemical Engineering Transactions, 2018
Hydrogen resource can be saved by reuse and purification reuse between refineries. Thus, it’s necessary to optimize the inter-plant hydrogen network in a petrochemical complex.
Yaqi Lou, Zuwei Liao, Xiaodong Hong, Jingyuan Sun, Binbo Jiang, Jingdai Wang, Yongrong Yang   +6 more
doaj   +1 more source

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

Enhanced ammonia decomposition using a Pd-Ag membrane reactor for high-purity hydrogen production

Fuel Processing Technology
In this study, a Pd-Ag membrane reactor (MR) integrated with a lab-synthesized ruthenium catalyst supported on La2Ce2O7 was used for the efficient production and recovery of highly-pure hydrogen from ammonia decomposition.
Erasmo Salvatore Napolitano, Cristina Italiano, Adele Brunetti, Minju Thomas, Antonio Vita, Giuseppe Barbieri   +5 more
doaj   +1 more source

Specifics of high-temperature sodium coolant purification technology in fast reactors for hydrogen production and other innovative applications

Nuclear Energy and Technology, 2017
In creating a large-scale atomic-hydrogen power industry, the resolution of technological issues associated with high temperatures in reactor plants (900°C) and large hydrogen concentrations intended as long-term resources takes on particular importance.
F.A. Kozlov, S.G. Kalyakin, A.P. Sorokin, V.V. Alekseev, A.A. Trufanov, M.A. Konovalov, E.A. Orlova   +6 more
doaj   +1 more source

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

Molecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi, Mandy Berndt‐Paetz, Eileen Lerner, Gregoire Najjar, Anca Azoitei, Krishna Pal Singh, Shailendra Kumar Gupta, Olaf Wolkenhauer, Cagatay Günes, Otmar Huber, Marc‐Oliver Grimm, Daniel Steinbach   +11 more
wiley   +1 more source

Effects of Purification on the Hydrogen Production in Biomass Gasification Process

Chemical Engineering Transactions, 2017
Energy from renewable sources such as biomass are expected to complement the energy derived from fossil fuel resources due to its abundant reserves and relatively low price compared with other energy sources.
M.B. Muslim, S. Saleh, N.A.F.A. Samad
doaj   +1 more source