Results 61 to 70 of about 686,296 (292)

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source

Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells

Molecular Oncology, EarlyView.
We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller, Susanne Ebner, Carmen Haselrieder, Julia K. Günther, Astrid Drasche, Sophie Strich, Chiara Volani, Andrea Medici, Aleksandar Nikolajevic, Alex Deltedesco, Johannes E. Sigmund, Michael J. Blumer, Martin Hermann, Johanna Vanacker, Gerald Brandacher, Eduard Stefan, Omar Torres‐Quesada, Jakob Troppmair   +17 more
wiley   +1 more source

Separation of Hydrogen Isotopes by Metal-Organic Framework Quantum Sieving Effect

He huaxue yu fangshe huaxue
Due to the similar physical and chemical properties of hydrogen isotopes, the separation of high-purity hydrogen isotopes has become one of the major problems in modern separation technology. The realization of high-purity hydrogen isotope separation can
Peng LIU, Jia-xian CHENG, Fu-qiu MA
doaj   +1 more source

Impact of Type Ia Supernova Ejecta on a Helium-star Binary Companion

, 2010
The impact of Type Ia supernova ejecta on a helium-star companion is investigated via high-resolution, two-dimensional hydrodynamic simulations. For a range of helium-star models and initial binary separations it is found that the mass unbound in the ...
Dessart, Domínguez, Dubey, Dwarkadas, Dwarkadas, Eggleton, Eggleton, Eggleton, Fryxell, Goldhaber, Hachisu, Hachisu, Hachisu, Hachisu, Hachisu, Howell, Ivanova, Kasen, Knop, Kuo-Chuan Pan, Leonard, Mannucci, Marietta, Meng, Meng, Paul M. Ricker, Riess, Ronald E. Taam, Scannapieco, Timmes, Waldman, Wang, Wang, Wickramasinghe   +33 more
core   +1 more source

Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma

Molecular Oncology, EarlyView.
Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken, Andrea Abel Gutierrez, Imke van Rossum, Cornelia G. Spruijt, Michiel Vermeulen, Guido van Mierlo, Blanca Scheijen, Annemiek B. van Spriel   +7 more
wiley   +1 more source

Review of Water Hydrogen Isotope Separation Technology

He huaxue yu fangshe huaxue
Hydrogen isotopes, such as protium(H), deuterium(D), and tritium(T), are widely used in medical treatment, nuclear energy, national defense, and other fields.
SHI Zhang-hong, ZHAO Qing-kai, CHEN Chang-an   +2 more
doaj   +1 more source

Inorganic Membranes for Hydrogen Separation

Separation & Purification Reviews, 2017
Hydrogen, one of the most promising energy carriers for the future, is currently produced mainly by natural gas reforming or coal gasification, where mixtures containing H2, CO2 and contaminants like CO, H2S and CH4 are obtained. Among other methods, membrane technology has received special attention due to its potential efficiency for hydrogen ...
Simão P Cardoso, Ivo S Azenha, Zhi Lin, Inês Portugal, Alírio E Rodrigues, Carlos M Silva   +5 more
openaire   +1 more source

Recurrent cancer‐associated ERBB4 mutations are transforming and confer resistance to targeted therapies

Molecular Oncology, EarlyView.
We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala, Sini Ahonen, Sara Peltola, Aura Tuohisto‐Kokko, Olaya Esparta, Peppi Suominen, Anne Jokilammi, Iman Farahani, Deepankar Chakroborty, Nikol Dibus, Steffen Boettcher, Tomi T. Airenne, Mark S. Johnson, Lisa D. Eli, Klaus Elenius, Kari J. Kurppa   +15 more
wiley   +1 more source

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source

Fabrication and Evaluation of Trimethylmethoxysilane (TMMOS)-Derived Membranes for Gas Separation

Membranes, 2019
Gas separation membranes were fabricated with varying trimethylmethoxysilane (TMMOS)/tetraethoxy orthosilicate (TEOS) ratios by a chemical vapor deposition (CVD) method at 650 °C and atmospheric pressure. The membrane had a high H2 permeance of 8.3 &
Yoshihiro Mise, So-Jin Ahn, Atsushi Takagaki, Ryuji Kikuchi, Shigeo Ted Oyama   +4 more
doaj   +1 more source