Results 21 to 30 of about 194,680 (219)
FEBS Letters, EarlyView.Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes +4 more
wiley +1 more source
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
FEBS Letters, EarlyView.Inositol pyrophosphates are energy‐rich signaling molecules that perform critical functions in cells. Three different families of phosphatases hydrolyze the β phosphate of the inositol pyrophosphate molecules: two have narrow specificities and one is promiscuous.
Ronda J. Rolfes
wiley +1 more source
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
Geofluids, 2022 Effective in situ scavenging of hydrogen sulfide (H2S) while drilling a sour formation is critical for limiting the prevalent related impacts and safety hazards.
Ashraf Ahmed +2 more
doaj +1 more source
Characteristics and pH-Responsiveness of SDBS–Stabilized Crude Oil/Water Nanoemulsions
Nanomaterials, 2022 Nanoemulsions are colloidal systems with a wide spectrum of applications in several industrial fields. In this study, crude oil-in-water (O/W) nanoemulsions were formulated using different dosages of the anionic sodium dodecylbenzenesulfonate (SDBS ...
Sagheer A. Onaizi
doaj +1 more source
CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3
Molecular Oncology, EarlyView.PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh +12 more
wiley +1 more source
Molecular Oncology, EarlyView.BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi +11 more
wiley +1 more source
EnergiesThe increasing integration of renewable energy sources has posed significant challenges to grid frequency stability. To maximize the advantages of energy storage in primary frequency regulation, this paper proposes a comprehensive control strategy for a ...
Haorui Jiang +3 more
doaj +1 more source
Study of the magnetostructural transition in critical-element free Mn1−xNi1−xFe2xSi0.95Al0.05
AIP Advances, 2023 Two different heat treatments have been carried out on similar Mn1−xNi1−xFe2xSi0.95Al0.05 compositions with magnetostructural transitions between hexagonal and orthorhombic crystal structures around room temperature.
Bruno G. F. Eggert +5 more
doaj +1 more source