Results 51 to 60 of about 636,938 (293)
Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma
Molecular Oncology, EarlyView.Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken +7 more
wiley +1 more source
Molecular Oncology, EarlyView.Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee +8 more
wiley +1 more source
Strain engineering on graphene towards tunable and reversible hydrogenation
, 2009 Graphene is the extreme material for molecular sensory and hydrogen storage applications because of its two-dimensional geometry and unique structure-property relationship.
Xu, Zhiping, Xue, Kun
core +1 more source
Enhanced hydrogen storage in Ni/Ce composite oxides [PDF]
, 2007 The properties of dried (but not calcined) coprecipitated nickel ceria systems have been investigated in terms of their hydrogen emission characteristics following activation in hydrogen.
Berlouis, Leonard E. A. +7 more
core +1 more source
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
A candidate LiBH4 for hydrogen storage: Crystal structures and reaction mechanisms of intermediate phases [PDF]
, 2005 First-principles calculation and x-ray diffraction simulation methods have been used to explore crystal structures and reaction mechanisms of the intermediate phases involved in dehydriding of LiBH4. LiBH4 was found to dehydride via two sequential steps:
Goddard, William A., III +4 more
core +1 more source
Molecular Oncology, EarlyView.Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute +4 more
wiley +1 more source
Ultrafast Hydrogen Production via Hydrolysis of MgH2-NaH Composite
MetalsMagnesium hydride (MgH2) has attracted considerable interest due to a number of favourable characteristics for hydrogen production via hydrolysis. In this study, MgH2-NaH composites with varying composition ratios were prepared by ball milling for ...
Zhao Zhang +6 more
doaj +1 more source
Nanomaterials, 2020 Hydrogen is widely regarded as a prime energy carrier for bridging the gap between renewable energy supply and demand. As the energy-generating component of the hydrogen cycle, affordable and reliable fuel cells are of key importance to the growth of the
Nicolas Delaporte +5 more
doaj +1 more source