Results 61 to 70 of about 151,216 (363)

Hispidin and Lepidine E: two Natural Compounds and Folic acid as Potential Inhibitors of 2019-novel coronavirus Main Protease (2019-nCoVMpro), molecular docking and SAR study [PDF]

arXiv, 2020
2019-nCoV is a novel coronavirus was isolated and identified in 2019 in Wuhan, China. On 17th February and according to world health organization, a number of 71 429 confirmed cases worldwide, among them 2162 new cases recorded in the last 24 hours. There is no drug or vaccine for human and animal coronavirus.
arxiv  

Glycoside Hydrolases Degrade Polymicrobial Bacterial Biofilms in Wounds

Antimicrobial Agents and Chemotherapy, 2016
The persistent nature of chronic wounds leaves them highly susceptible to invasion by a variety of pathogens that have the ability to construct an extracellular polymeric substance (EPS).
Derek F Fleming, Laura Chahin, K. Rumbaugh   +2 more
semanticscholar   +1 more source

Plasma lipidomic and metabolomic profiles in high‐grade glioma patients before and after 72‐h presurgery water‐only fasting

Molecular Oncology, EarlyView.
Presurgery 72‐h fasting in GB patients leads to adaptations of plasma lipids and polar metabolites. Fasting reduces lysophosphatidylcholines and increases free fatty acids, shifts triglycerides toward long‐chain TGs and increases branched‐chain amino acids, alpha aminobutyric acid, and uric acid.
Iris Divé, Lisa Hahnefeld, Katharina J. Wenger, Donat Kögel, Joachim Steinbach, Gerd Geisslinger, Michael W. Ronellenfitsch, Irmgard Tegeder   +7 more
wiley   +1 more source

The Role of Cytochrome P450 AbyV in the Final Stages of Abyssomicin C Biosynthesis

Angewandte Chemie International Edition, Volume 62, Issue 3, January 16, 2023., 2023
The cytochrome P450 enzyme AbyV catalyses a key epoxidation in the final stages of the biosynthesis of the spirotetronate antibiotic abyssomicin C. Combining structural and computational data with a 13C labelling strategy was found to be a powerful approach to interrogate the biotransformation and determine the precise function of the enzyme.
Andrew J. Devine, Alice E. Parnell, Catherine R. Back, Nicholas R. Lees, Samuel T. Johns, Ainul Z. Zulkepli, Rob Barringer, Katja Zorn, James E. M. Stach, Matthew P. Crump, Martin A. Hayes, Marc W. van der Kamp, Paul R. Race, Christine L. Willis   +13 more
wiley   +1 more source

Microbial glycoside hydrolases as antibiofilm agents with cross-kingdom activity

Proceedings of the National Academy of Sciences of the United States of America, 2017
Significance The production of biofilms is an important strategy used by both bacteria and fungi to colonize surfaces and to enhance resistance to killing by immune cells and antimicrobial agents. We demonstrate that glycoside hydrolases derived from the
Brendan D. Snarr, Brendan D. Snarr, Perrin Baker, N. C. Bamford, Yukiko Sato, Yukiko Sato, Hong Liu, M. Lehoux, Fabrice N Gravelat, Hanna Ostapska, Hanna Ostapska, Shane R Baistrocchi, Shane R Baistrocchi, Robert P. Cerone, Robert P. Cerone, Elan E. Filler, M. Parsek, S. Filler, S. Filler, P. Howell, Donald C. Sheppard, Donald C. Sheppard   +21 more
semanticscholar   +1 more source

Ubiquitination of transcription factors in cancer: unveiling therapeutic potential

Molecular Oncology, EarlyView.
In cancer, dysregulated ubiquitination of transcription factors contributes to the uncontrolled growth and survival characteristics of tumors. Tumor suppressors are degraded by aberrant ubiquitination, or oncogenic transcription factors gain stability through ubiquitination, thereby promoting tumorigenesis.
Dongha Kim, Hye Jin Nam, Sung Hee Baek
wiley   +1 more source

An exhaustive multiple knockout approach to understanding cell wall hydrolase function in Bacillus subtilis

mBio, 2023
Most bacteria are surrounded by their cell wall, containing a highly cross-linked protective envelope of peptidoglycan. To grow, bacteria must continuously remodel their wall, inserting new material and breaking old bonds.
Sean A. Wilson, Raveen K. J. Tank, Jamie K. Hobbs, Simon J. Foster, Ethan C. Garner   +4 more
doaj   +1 more source

A chemical proteomic atlas of brain serine hydrolases identifies cell type-specific pathways regulating neuroinflammation

eLife, 2016
Metabolic specialization among major brain cell types is central to nervous system function and determined in large part by the cellular distribution of enzymes.
Andreu Viader, Daisuke Ogasawara, Christopher M. Joslyn, M. Sánchez-Alavez, Simone Mori, William Nguyen, B. Conti, B. Cravatt   +7 more
semanticscholar   +1 more source

Comparative study of adenosine 3′‐pyrophosphokinase domains of MuF polymorphic toxins

FEBS Open Bio, EarlyView.
With the ultimate goal of understanding the association of toxin‐immunity modules to temperate phages, we characterized toxins from three prophages and examined cross‐protection from immunity proteins. The toxins exhibit adenosine 3′‐pyrophosphokinase activity and are toxic in Escherichia coli.
Eloïse M. Paulet, Julia Bartoli, Atakan Kabtan, Chloé M. Piras, Audrey C. Tempier, Eric Cascales, Julie P. Viala   +6 more
wiley   +1 more source

Calcium modulating ligand confers risk for Parkinson's disease and impacts lysosomes

Annals of Clinical and Translational Neurology, EarlyView.
Abstract Objective Several genetic loci known to confer risk for Parkinson's disease (PD) function in lysosomal pathways. We systematically screened common variants linked to PD risk by genome‐wide association studies (GWAS) for impact on cerebrospinal fluid (CSF) proteins reflecting lysosomal function.
Hanwen Zhang, Daniel Kargilis, Thomas Tropea, John Robinson, Junchao Shen, Eliza M. Brody, Ann Brinkmalm, Simon Sjödin, Adama J. Berndt, Marc Carceles‐Cordon, EunRan Suh, Vivianna M. Van Deerlin, Kaj Blennow, Daniel Weintraub, Edward B. Lee, Henrik Zetterberg, Alice S. Chen‐Plotkin   +16 more
wiley   +1 more source