Halophilic Bacteria as a Source of Novel Hydrolytic Enzymes
Life, 2013 Hydrolases constitute a class of enzymes widely distributed in nature from bacteria to higher eukaryotes. The halotolerance of many enzymes derived from halophilic bacteria can be exploited wherever enzymatic transformations are required to function ...
Encarnación Mellado +3 more
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Functional Traits Co-Occurring with Mobile Genetic Elements in the Microbiome of the Atacama Desert [PDF]
, 2019 Mobile genetic elements (MGEs) play an essential role in bacterial adaptation and evolution. These elements are enriched within bacterial communities from extreme environments. However, very little is known if specific genes co-occur with MGEs in extreme
Airo, Alessandro +4 more
core +1 more source
Marine Extremophiles: A Source of Hydrolases for Biotechnological Applications
Marine Drugs, 2015 The marine environment covers almost three quarters of the planet and is where evolution took its first steps. Extremophile microorganisms are found in several extreme marine environments, such as hydrothermal vents, hot springs, salty lakes and deep-sea
Gabriel Zamith Leal Dalmaso +2 more
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Structural and functional characterization of a cold-adapted stand-alone TPM domain reveals a relationship between dynamics and phosphatase activity [PDF]
, 2018 The TPM domain constitutes a family of recently characterized protein domains that are present in most living organisms. Although some progress has been made in understanding the cellular role of TPM-containing proteins, the relationship between ...
Aran, Martin +5 more
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INHIBITION AND ACTIVATION OF BARLEY PEPTIDE HYDROLASES I. PEPTIDE HYDROLASE A [PDF]
Journal of the Institute of Brewing, 1971 Barley peptide hydrolase A acting on N-benzoyl-dl-arginine-p-nitroanilide as substrate is inhibited by the sulphydryl reagents N-ethyl maleimide and p-chloro-mercuriphenyl sulphonate. Oxidized glutathione, however, is non-inhibitory and several sulphydryl compounds are not stimulatory.
W.C. Burger +2 more
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Enzyme-Based Anti-Inflammatory Therapeutics for Inflammatory Diseases
PharmaceuticsInflammation is a multifaceted biological response of the immune system against various harmful stimuli, including pathogens (such as bacteria and viruses), cellular damage, toxins, and natural/synthetic irritants.
Kannan Badri Narayanan
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Les lipases sont des hydrolases atypiques : principales caractéristiques et applications [PDF]
, 2008 ipases are atypical hydrolases: principal characteristics and applications. Due to their kinetic and substrate specificities, triacylglycerol acyl-hydrolases or lipases are atypical enzymes.
Destain J., Fickers P., Thonart P.
core
Structural genomics analysis of uncharacterized protein families overrepresented in human gut bacteria identifies a novel glycoside hydrolase. [PDF]
, 2014 BackgroundBacteroides spp. form a significant part of our gut microbiome and are well known for optimized metabolism of diverse polysaccharides. Initial analysis of the archetypal Bacteroides thetaiotaomicron genome identified 172 glycosyl hydrolases and
Axelrod, Herbert L +7 more
core +2 more sources
Molecules, 2018 PH46A is a single enantiomer and a member of the 1,2-indane dimer family. It has two contiguous stereogenic centers with S,S configurations, one of which being a quaternary center, which has been developed as a clinical candidate for the treatment of ...
Tao Zhang +3 more
doaj +1 more source
Hydration of vinyl ether groups by unsaturated glycoside hydrolases and their role in bacterial pathogenesis [PDF]
, 2008 Many pathogenic microorganisms invade mammalian and/or plant cells by producing polysaccharide-degrading enzymes (lyases and hydrolases). Mammalian glycosaminoglycans and plant pectins that form part of the cell surface matrix are typical targets for ...
Bunzo Mikami +4 more
core +2 more sources