Results 231 to 240 of about 1,031,507 (300)

Endogenous “Time Bomb” – Mislocalized Phospholipase A2 as a Critical Mediator of Ultra‐Rapid Mortality in Sepsis and Acute Lung Injury

Advanced Science, EarlyView.
Phospholipase A2 (PLA2), a dormant enzyme, becomes lethal when activated—collapsing lungs in minutes. Our dual therapy (DOPS + varespladib) boosts survival from 0% to >90% in sepsis/ALI. A breakthrough for acute lung injury treatment. ABSTRACT This study reveals that phospholipase A2 (PLA2), normally stable and nontoxic, can be activated specifically ...
Jianyu Wang, Zhongxing Xu, Lin Wang, Xin Sui, Yuan Luo, Xiuli Zhao, Jun Yang, Yongan Wang   +7 more
wiley   +1 more source

HYDROLYSIS OF PROTEINS

Cold Spring Harbor Symposia on Quantitative Biology, 1950
openaire   +2 more sources

Understanding and Overcoming Antibody‐Drug Conjugate Resistance: Biological Mechanisms and Emerging Analytical Frameworks in Breast Cancer

Advanced Science, EarlyView.
Antibody–drug conjugates (ADCs) transform breast cancer therapy, yet resistance limits their durability. Emerging evidence reveals that ADC failure is not solely tumor‐intrinsic but shaped by dynamic tumor–microenvironment interactions that alter drug delivery, processing, and response.
Minji Seo, Jangsoon Lee, Naoto T. Ueno
wiley   +1 more source

Mechanism-Guided Precision Hydrolysis of Early Transition Metals to Access (Mixed-Metal) Oxo Clusters. [PDF]

Angew Chem Int Ed Engl
Parammal MJ, Pulparayil Mathew J, Prescimone A, Unniram Parambil AR, Wilson H, De Roo J.   +5 more
europepmc   +1 more source

A Nanoparticle‐Integrated Complete Manufacturing Pipeline of Chemically Engineered Exosomes

Advanced Science, EarlyView.
We report a novel manufacture technology of chemically engineered exosomes. The four steps of manufacturing, i.e., biogenesis, loading, isolation, and storage, are integrated by the use of a nanoparticle. The manufacture technology incorporates three innovative components, i.e., a new nano‐bio effect, a new composite nanoparticle, and a new isolation ...
Xiaowei Wen, Zixing Xu, Zerun Hao, Yanming Chen, Kai Xie, Haofan Yin, Xueying Wang, Jie Min, Sihan Sun, Baiding Chen, Chengxiu Ling, Mingming Xu, Yizhao Chen, Gang Ruan   +13 more
wiley   +1 more source

Hydrolysis of Glycogen

The Journal of Physiology, 1898
openaire   +3 more sources

Mechanism of Hsp70 activation: How J-domain proteins push for ATP hydrolysis. [PDF]

PLoS Comput Biol
Olewniczak M, Pitek M, Czub J, Marszalek J, Nierzwicki Ł, Tomiczek B.   +5 more
europepmc   +1 more source

Properties of foamed concrete utilizing Fe(II) as foam stabilizer for hydrolyzed pumpkin seed protein. [PDF]

Sci Rep
Song N, Zhang Z, Ma C, Hu G, Lai Y, Cui J.   +5 more
europepmc   +1 more source