Results 41 to 50 of about 634,830 (282)

Collapse transitions of a periodic hydrophilic hydrophobic chain

, 1998
We study a single self avoiding hydrophilic hydrophobic polymer chain, through Monte Carlo lattice simulations. The affinity of monomer $i$ for water is characterized by a (scalar) charge $\lambda_{i}$, and the monomer-water interaction is short-ranged ...
Garel, T., Orlandini, E.
core   +1 more source

Recurrent cancer‐associated ERBB4 mutations are transforming and confer resistance to targeted therapies

Molecular Oncology, EarlyView.
We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala, Sini Ahonen, Sara Peltola, Aura Tuohisto‐Kokko, Olaya Esparta, Peppi Suominen, Anne Jokilammi, Iman Farahani, Deepankar Chakroborty, Nikol Dibus, Steffen Boettcher, Tomi T. Airenne, Mark S. Johnson, Lisa D. Eli, Klaus Elenius, Kari J. Kurppa   +15 more
wiley   +1 more source

Influence of Temperature on the Frictional Properties of Water-Lubricated Surfaces

Lubricants, 2014
The influence of temperature on the lubricating properties of neat water for tribopairs with varying bulk elasticity moduli and surface hydrophilicity, namely hard-hydrophobic interface (h-HB), hard-hydrophilic interface (h-HL), soft-hydrophobic ...
Troels Røn, Seunghwan Lee
doaj   +1 more source

Hydrodynamics of the Developing Region in Hydrophobic Microchannels: A Dissipative Particle Dynamics Study

, 2012
Dissipative Particle Dynamics (DPD) is becoming a popular particle based method to study flow through microchannels due to the ease with which the presence of biological cells or DNA chains can be modeled.
Patnaik, B. S. V., Ranjith, S. Kumar, Vedantam, Srikanth   +2 more
core   +1 more source

Tailoring pH-responsive acrylic acid microgels with hydrophobic crosslinks for drug release [PDF]

, 2015
Amphiphilic microgels based on the hydrophilic acrylic acid (AA) and hydrophobic crosslinks of different compositions were synthesised using a lab-on-a-chip device. The microgels were formed by polymerising hydrophobic droplets.
Georgiou, T. K., Lu, B., Pamme, N., Tarn, M. D.   +3 more
core   +2 more sources

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Overview of molecular signatures of senescence and associated resources: pros and cons

FEBS Open Bio, EarlyView.
Cells can enter a stress response state termed cellular senescence that is involved in various diseases and aging. Detecting these cells is challenging due to the lack of universal biomarkers. This review presents the current state of senescence identification, from biomarkers to molecular signatures, compares tools and approaches, and highlights ...
Orestis A. Ntintas, Sylvia Vagena, Pavlos Pantelis, Giorgos Theocharous, Russel Petty, Konstantinos Evangelou, Vassilis G. Gorgoulis   +6 more
wiley   +1 more source

Innovations In Formulation And Evaluation Of Oral Fast Dissolving Film

Eurasian Journal of Science and Engineering, 2023
The most popular and convenient route for the drug administration is oral route with some merits, demerits, and limitations with some paediatric and geriatrics patients as they face difficulty to take solid dosage forms like capsules or compressed ...
Rozhan Arif Muhammed, Zainab Yalman, Bushra Rashid Noaman, Sharad Visht, Sarmad Jabbar, Sana Sirwan Salih   +5 more
doaj   +1 more source

The effect of NOM characteristics and membrane type on microfiltration performance [PDF]

, 2007
Efforts to understand and predict the role of different organic fractions in the fouling of low-pressure membranes are presented. Preliminary experiments with an experimental apparatus that incorporates automatic backwashing and filtration over several ...
Bolto, Brian, Gray, Stephen R, Ritchie, C. B, Tran, Thuy   +3 more
core  

Micelle formation, gelation and phase separation of amphiphilic multiblock copolymers

, 2011
The phase behaviour of amphiphilic multiblock copolymers with a large number of blocks in semidilute solutions is studied by lattice Monte Carlo simulations.
Anderson, Arisz, Bae, Berndt, Bhatia, Binder, Bodvik, Borisov, Cates, Chandler, Chevillard, Chushak, Cooke, Dasmahapatra, Denkova, Determan, Determan, Fatimi, Floriano, Forster, Gil, Gindy, Glotzer, Guillot, Halperin, Hirrien, Hourdet, Hugouvieux, Hummer, Kataoka, Kikuchi, Kikuchi, Kobayashi, Kosovan, Kuldová, Lairez, Larson, Li, Li, Lintuvuori, Max Kolb, Meyer, Monique A. V. Axelos, Regalado, Riess, Sarkar, Tanaka, Virginie Hugouvieux, Wijmans, Zhang, Zhou   +50 more
core   +1 more source