Results 41 to 50 of about 775,144 (299)

Degradation mechanism of the von Willebrand factor A2 domain by nattokinase

FEBS Letters, EarlyView.
Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto, Masatomo So, Ayako Furukawa, Kenji Sugase   +3 more
wiley   +1 more source

Hydrophobic treatments and their application with internal wall insulation

UCL Open Environment
Hydrophobic (or water repellent) treatments have been proposed to mitigate moisture risks associated with internal wall insulation when applied to solid masonry walls.
Hector Altamirano, Toby Cambray, Valentina Marincioni   +2 more
doaj   +2 more sources

μ-calpain binds to lipid bilayers via the exposed hydrophobic surface of its Ca2+-activated conformation [PDF]

, 2006
μ- and m-calpain are cysteine proteases requiring micro- and millimolar Ca2+ concentrations for their activation in vitro. Among other mechanisms, interaction of calpains with membrane phospholipids has been proposed to facilitate their activation by ...
Machleidt, Werner, Assfalg-Machleidt, Irmgard, Fernández-Montalván, Amaury, Pfeiler, Dietmar, Jochum, Marianne, Fritz, Hans   +5 more
core   +1 more source

Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions

FEBS Letters, EarlyView.
The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang, Hyo Been Jin, Chang Min Kim, So Yeon Lee, Hyun Ho Park   +4 more
wiley   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Facile Synthesis of Highly Hydrophobic Cellulose Nanoparticles through Post-Esterification Microfluidization

Fibers, 2018
A post-esterification with a high degree of substitution (hDS) mechanical treatment (Pe(hDS)M) approach was used for the production of highly hydrophobic cellulose nanoparticles (CNPs).
Chunxiang Lin, Qianli Ma, Qiaoquan Su, Huiyang Bian, J. Y. Zhu   +4 more
doaj   +1 more source

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Hydrophobic Surface Array Structure Based on Laser-Induced Graphene for Deicing and Anti-Icing Applications

Micromachines
The exceptional performance of graphene has driven the advancement of its preparation techniques and applications. Laser-induced graphene (LIG), as a novel graphene preparation technique, has been applied in various fields.
Mian Zhong, Shichen Li, Yao Zou, Hongyun Fan, Yong Jiang, Chao Qiu, Jinling Luo, Liang Yang   +7 more
doaj   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Studies on Stable Formulations for a Hydrophobic Cytokine [PDF]

, 2006
The goal of the thesis was to analyze the impact of the formulation conditions on the stabilization of a hydrophobic cytokine. A standard way to formulate the cytokine at physiological pH is using Human Serum Albumin (HSA) as excipient.
Hawe, Andrea
core   +1 more source