Tau acetylation at K331 has limited impact on tau pathology in vivo
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
wiley +1 more source
Reações orgânicas em meio aquoso
The use of water as solvent in organic reactions has been uncommon for several reasons, among them the low solubility of the reactants, the incompatibility of the intermediates with water, and the competition between the desired reaction and hydrolysis ...
Silva Flavia Martins da, Jones Jr Joel
doaj
Effect of biocomposite edible coatings based on pea starch and guar gum on nutritional quality of ‘Valencia’ orange during storage [PDF]
Application of environmentally friendly components is an approach for substitution of synthetic substances in commercial waxes applied to citrus. In this study, the effect of biocomposite edible coatings based on pea starch and guar gum (PSGG) on total ...
Chockchaisawasdee, Suwimol +4 more
core +2 more sources
Thermodynamics of the Hydrophobic Effect [PDF]
A thermodynamic theory is developed describing the transfer process of nonpolar substances from water to their pure state and the micellization process. The basis of the theory is the consideration, experimentally supported, that to a first-order approximation the change in the standard molar entropy (ΔS°) can be consider proportional to the standard ...
José Manuel del Río, Malcolm N. Jones
openaire +1 more source
Calpain small subunit homodimerization is robust and calcium‐independent
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy +4 more
wiley +1 more source
Conductometric study of sodium dodecyl sulfate - nonionic surfactant (Triton X-100, Tween 20, Tween 60, Tween 80 or Tween 85) mixed micelles in aqueous solution [PDF]
The present study is concerned with the determination of the critical micelle concentration (cmc) of mixed micelles of sodium dodecyl sulfate with one of five nonionic surfactants (Triton X-100, Tween 20, Tween 60, Tween 80 or Tween 85) from ...
Ćirin Dejan M. +3 more
doaj +1 more source
Effect of hydrophobic solutes on the liquid-liquid critical point
Jagla ramp particles, interacting through a ramp potential with two characteristic length scales, are known to show in their bulk phase thermodynamic and dynamic anomalies, similar to what is found in water.
C. Tanford +5 more
core +1 more source
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
Polymeric ultralong organic phosphorescence (UOP) with persistent emission is of great importance in practical applications. However, achieving good water‐resistance for long‐term environmental stability is a formidable challenge.
Zhongyu Li +10 more
doaj +1 more source
On the Effective Charge of Hydrophobic Polyelectrolytes [PDF]
In this paper, we analyze the behavior of hydrophobic polyelectrolytes. It has been proposed that this system adopts a pearl necklace structure reminiscent of the Rayleigh instability of a charged droplet. Using a Poisson-Boltzmann approach, we calculate the counterion distribution around a given pearl, assuming the latter to be penetrable for the ...
A, Chepelianskii +3 more
openaire +2 more sources

