Results 71 to 80 of about 755,747 (299)

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source

The Combined Effect of Hydrophobic Mismatch and Bilayer Local Bending on the Regulation of Mechanosensitive Ion Channels. [PDF]

PLoS ONE, 2016
The hydrophobic mismatch between the lipid bilayer and integral membrane proteins has well-defined effect on mechanosensitive (MS) ion channels. Also, membrane local bending is suggested to modulate MS channel activity.
Omid Bavi, Manouchehr Vossoughi, Reza Naghdabadi, Yousef Jamali   +3 more
doaj   +1 more source

Dynamics of simple liquids at heterogeneous surfaces : Molecular Dynamics simulations and hydrodynamic description

, 2004
In this paper we consider the effect of surface heterogeneity on the slippage of fluid, using two complementary approaches. First, MD simulations of a corrugated hydrophobic surface have been performed.
Alexeyev, Andrienko, Barrat, Barrat, Baudry, Bonaccurso, Bonaccurso, C. Barentin, C. Cottin-Bizonne, Cheng, Choi, Churaev, Cottin-Bizonne, Cottin-Bizonne, Craig, J. -L. Barrat, L. Bocquet, Lafuma, Lauga, Lefevre, Lum, Philip, Pit, Ponomarev, Richardson, Thompson, Vinogradova, Vinogradova, Watanabe, Zhu, Zhu, É. Charlaix   +31 more
core   +1 more source

Effect of hydrophobic modifications in antimicrobial peptides [PDF]

Advances in Colloid and Interface Science, 2014
With increasing resistance development against conventional antibiotics, there is an urgent need to identify novel approaches for infection treatment. Antimicrobial peptides may offer opportunities in this context, hence there has been considerable interest in identification and optimization of such peptides during the last decade in particular, with ...
Schmidtchen, Artur, Pasupuleti, Mukesh, Malmsten, Martin   +2 more
openaire   +3 more sources

Recurrent cancer‐associated ERBB4 mutations are transforming and confer resistance to targeted therapies

Molecular Oncology, EarlyView.
We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala, Sini Ahonen, Sara Peltola, Aura Tuohisto‐Kokko, Olaya Esparta, Peppi Suominen, Anne Jokilammi, Iman Farahani, Deepankar Chakroborty, Nikol Dibus, Steffen Boettcher, Tomi T. Airenne, Mark S. Johnson, Lisa D. Eli, Klaus Elenius, Kari J. Kurppa   +15 more
wiley   +1 more source

Weak interactions-Strong effects: Key role of hydrophobic interaction in the formation of stimuli-responsive viscoelastic gel of worm-like micelles

Bibechana, 2014
Among all the weak interactions, which are operative in the domain of chemistry, hydrophobic effect is one that leads to new structural motifs like molecular self-assemblies viz., micelles, vesicles etc.
Swapan K. Saha
doaj   +3 more sources

Hydrophobic Effects. Opinions and Facts

Angewandte Chemie International Edition in English, 1993
AbstractThe term hydrophobic interactions denotes the tendency of relatively apolar molecules to stick together in aqueous solution. These interactions are of importance in many chemical disciplines, including the chemistry of in vivo processes. Enzyme‐substrate interactions, the assembly of lipids in biomembranes, surfactant aggregation, and kinetic ...
Wilfried Blokzijl, Jan B. F. N. Engberts
openaire   +3 more sources

Inhibition of protein aggregation: supramolecular assemblies of arginine hold the key. [PDF]

PLoS ONE, 2007
BACKGROUND: Aggregation of unfolded proteins occurs mainly through the exposed hydrophobic surfaces. Any mechanism of inhibition of this aggregation should explain the prevention of these hydrophobic interactions.
Utpal Das, Gururao Hariprasad, Abdul S Ethayathulla, Pallavi Manral, Taposh K Das, Santosh Pasha, Anita Mann, Munia Ganguli, Amit K Verma, Rajiv Bhat, Sanjeev Kumar Chandrayan, Shubbir Ahmed, Sujata Sharma, Punit Kaur, Tej P Singh, Alagiri Srinivasan   +15 more
doaj   +1 more source

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source