Results 51 to 60 of about 289,831 (273)

Peptide‐based ligand antagonists block a Vibrio cholerae adhesin

FEBS Letters, EarlyView.
The structure of a peptide‐binding domain of the Vibrio cholerae adhesin FrhA was solved by X‐ray crystallography, revealing how the inhibitory peptide AGYTD binds tightly at its Ca2+‐coordinated pocket. Structure‐guided design incorporating D‐amino acids enhanced binding affinity, providing a foundation for developing anti‐adhesion therapeutics ...
Mingyu Wang, Grace Du, Charity Yongo‐Luwawa, Angelina Lu, Brett Kinrade, Kim Munro, Karl E. Klose, William D. Lubell, Peter Davies, Shuaiqi Guo   +9 more
wiley   +1 more source

Research on the Hydrophobicity of Square Column Structures on Monocrystalline Silicon Fabricated Using Micro-Machining

Micromachines, 2019
The theoretical prediction models of contact angle were constructed by considering the interface free energy. Then, the square column structure on monocrystalline silicon was fabricated using micro-milling.
Ziyang Cao, Wenyu Ding, Zhenwu Ma, Bangfu Wang, Zhongwang Wang   +4 more
doaj   +1 more source

Biophysical Interactions Underpin the Emergence of Information in the Genetic Code

Life, 2023
The genetic code conceals a ‘code within the codons’, which hints at biophysical interactions between amino acids and their cognate nucleotides. Yet, research over decades has failed to corroborate systematic biophysical interactions across the code ...
Aaron Halpern, Lilly R. Bartsch, Kaan Ibrahim, Stuart A. Harrison, Minkoo Ahn, John Christodoulou, Nick Lane   +6 more
doaj   +1 more source

A machine learning approach to explore the spectra intensity pattern of peptides using tandem mass spectrometry data [PDF]

, 2008
Background: A better understanding of the mechanisms involved in gas-phase fragmentation of peptides is essential for the development of more reliable algorithms for high-throughput protein identification using mass spectrometry (MS).
Bowler, Lucas D., Feng, Jianfeng, Zhou, Cong   +2 more
core   +5 more sources

Disordered but rhythmic—the role of intrinsic protein disorder in eukaryotic circadian timing

FEBS Letters, EarlyView.
Unstructured domains known as intrinsically disordered regions (IDRs) are present in nearly every part of the eukaryotic core circadian oscillator. IDRs enable many diverse inter‐ and intramolecular interactions that support clock function. IDR conformations are highly tunable by post‐translational modifications and environmental conditions, which ...
Emery T. Usher, Jacqueline F. Pelham
wiley   +1 more source

Effects of heating on hydrophobicity, viscosity, and gelling properties of soy products [PDF]

, 2005
The co-product of soybean after oil extraction is the meal, which is rich in protein. From this meal, protein concentrate and protein isolate are prepared and are commercially available as functional ingredients. Thermal treatment is the most common step
Hettiarachchy, Navam S., Horax, Ronny, Walnofer, Robert S.   +2 more
core   +2 more sources

Effects of hydrocarbon spills on the temperature and moisture regimes of Cryosols in the Ross Sea region [PDF]

, 2002
Hydrocarbon spills have occurred on Antarctic soils where fuel oils are utilized, moved or stored. We investigated the effects of hydrocarbon spills on soil temperature and moisture regimes by comparing the properties of existing oil contaminated sites ...
Aislabie, Jackie M., Balks, Megan R., Campbell, Iain B., Kimble, John M., Paetzold, Ron F.   +4 more
core   +2 more sources

Substrate specificity of Burkholderia pseudomallei multidrug transporters is influenced by the hydrophilic patch in the substrate‐binding pocket

FEBS Letters, EarlyView.
Multidrug transporters BpeB and BpeF from the Gram‐negative pathogen Burkholderia pseudomallei have a hydrophilic patch in their substrate‐binding pocket. Drug susceptibility tests and growth curve analyses using an Escherichia coli recombinant expression system revealed that the hydrophilic patches of BpeB and BpeF are involved in the substrate ...
Ui Okada, Satoshi Murakami
wiley   +1 more source

Cuticular Wax Triterpenes Maintain Storage Quality of Blueberries by Reducing Water Loss

Foods, 2023
Cuticular wax contributes to maintaining postharvest storage quality against fruit water loss and softening. Triterpenoids, such as oleanolic acid (OA) and ursolic acid (UA), are the main components in blueberry cuticular wax, but their role in water ...
Qi Kong, Ruiling Liu, Weijie Wu, Xiangjun Fang, Hangjun Chen, Yanchao Han, Jianye Chen   +6 more
doaj   +1 more source

Conserved structural motifs in PAS, LOV, and CRY proteins regulate circadian rhythms and are therapeutic targets

FEBS Letters, EarlyView.
Cryptochrome and PAS/LOV proteins play intricate roles in circadian clocks where they act as both sensors and mediators of protein–protein interactions. Their ubiquitous presence in signaling networks has positioned them as targets for small‐molecule therapeutics. This review provides a structural introduction to these protein families.
Eric D. Brinckman, Anna E. Lester, Brian D. Zoltowski   +2 more
wiley   +1 more source