Results 111 to 120 of about 19,186 (210)

Translation inhibition by rocaglates is independent of eIF4E phosphorylation status [PDF]

, 2016
Rocaglates are natural products that inhibit protein synthesis in eukaryotes and exhibit antineoplastic activity. In vitro biochemical assays, affinity chromatography experiments coupled with mass spectrometry analysis, and in vivo genetic screens have ...
Cencic, Regina, Chu, Jennifer, Pelletier, Jerry, Porco, John A., Wang, Wenyu   +4 more
core   +1 more source

Pharmacological Effects of Anthranilic Hydroxamic Acid and Certain Other Hydroxamic Acids

Experimental Biology and Medicine, 1960
SummaryThe hydroxamate of anthranilic acid injected intraperitoneally into rats in a dose of 1.0 mg/g causes anesthesia lasting 10 hours or more. Recovery is apparently complete. One half this dose causes tranquilization and suppression of the conditioned avoidance response. The compound protects mice against twice the lethal dose of strychnine.
F. Bernheim, J. K. Stoops
openaire   +1 more source

MMP-13 Selective α-sulfone Hydroxamates: a Survey of P1\u27 Heterocyclic Amide Isosteres [PDF]

, 2011
Seeking compounds preferentially potent and selective for MMP-13, we reported in the preceding Letter on a series of hydroxamic acids with a flexible benzamide tail groups.(1a) Here, we replace the amide moiety with non-hydrolyzable heterocycles in an ...
Barta, Thomas E., Becker, Daniel P., Bedell, Louis J., Easton, Alan M.   +3 more
core  

Total Synthesis of Talarolide A and atrop-Talarolide A: Hydroxamate H-Bond Bridge Stabilization of Cyclic Peptide Conformers Invokes Non-Canonical Atropisomerism

Marine Drugs
The first total synthesis of the Australian marine tunicate fungus-derived cyclic peptide talarolide A (1) has confirmed the structure previously proposed on the basis of spectroscopic and chemical analyses and re-affirmed the importance of the unique ...
Waleed M. Hussein, Yuxuan Zhu, Angela A. Salim, Robert J. Capon   +3 more
doaj   +1 more source

Synthesis, Crystal Structures, and Catalytic Oxidation Property of Oxidovanadium(V) Complexes with Hydrazone and Hydroxamate Ligands

Acta Chimica Slovenica, 2014
Two new hydrazone ligands were synthesized and characterized by common spectroscopic and analytical methods. Two new oxidovanadium(V) complexes with the hydrazone ligands and hydroxamate ligands were synthesized and characterized by infrared spectra and ...
Kui-Hua Yang
doaj  

Nonenzymatic formation of energy-rich lactoyl and glyceroyl thioesters from glyceraldehyde and a thiol [PDF]

The energy rich thioester, N-acetyl-S-lactoylcysteine, is formed under anaerobic conditions from glyceraldehyde and N-acetylcysteine at ambient temperature in aqueous solutions of sodium phosphate (pH 7.0).
Weber, A. L.
core   +1 more source

Discovery of a novel hybrid coumarin-hydroxamate conjugate targeting the HDAC1-Sp1-FOSL2 signaling axis for breast cancer therapy

Cell Communication and Signaling
Background Breast cancer is one of the most lethal cancers in women. Despite significant advances in the diagnosis and treatment of breast cancer, many patients still succumb to this disease, and thus, novel effective treatments are urgently needed ...
Sujie Zhu, Wenjing Zhu, Kaihua Zhao, Jie Yu, Wenxia Lu, Rui Zhou, Shule Fan, Weikaixin Kong, Feifei Yang, Peipei Shan   +9 more
doaj   +1 more source

The Schizosaccharomyces pombe ornithine-N5-oxygenase Sib2 interacts with the N5-transacetylase Sib3 in the ferrichrome biosynthetic pathway

Frontiers in Microbiology
The fission yeast Schizosaccharomyces pombe produces the hydroxamate-type siderophore ferrichrome (Fc). The biosynthesis of Fc requires the Fc synthase Sib1, the ornithine-N5-oxygenase Sib2, and the N5-hydroxyornithine-N5-transacetylase Sib3.
Berthy Mbuya, Samuel Plante, Farouk Ammar, Ariane Brault, Simon Labbé   +4 more
doaj   +1 more source

Hydroxamic Acids [PDF]

, 2020
openaire   +1 more source

The role of FoxA, FiuA, and FpvB in iron acquisition via hydroxamate-type siderophores in Pseudomonas aeruginosa

Scientific Reports
Siderophores are specialized molecules produced by bacteria and fungi to scavenge iron, a crucial nutrient for growth and metabolism. Catecholate-type siderophores are mainly produced by bacteria, while hydroxamates are mostly from fungi.
Virginie Will, Chloé Frey, Vincent Normant, Lauriane Kuhn, Johana Chicher, Florian Volck, Isabelle J. Schalk   +6 more
doaj   +1 more source