Results 181 to 190 of about 19,186 (210)
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Hydroxamic Acids as Pharmacological Agents
Current Medicinal Chemistry, 2002A variety of hydroxamic acid derivatives have recently been touted for their potential use as inhibitors of hypertension, tumor growth, inflammation, infectious agents, asthma, arthritis, and more. Here we provide a comprehensive review of the basic medicinal chemistry and pharmacology of hydroxamic acid derivatives that have been examined as ...
Muri, Estela M.F. +3 more
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Hydroxamate siderophores of Scedosporium apiospermum
BioMetals, 2009Scedosporium apiospermum is an emerging pathogen colonizing the airways of patients with cystic fibrosis and causing severe infections in immunocompromised hosts. In order to improve our knowledge on the pathogenic mechanisms of this fungus, we investigated the production of siderophores.
Bertrand, Samuel +5 more
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Tetradentate Bis(hydroxamate) and Hydroxamate-Diketonate Ligands and Their Titanium(IV) Complexes
Inorganic Chemistry, 2008A 2,2'-bis(methylene)biphenyl-bridged bis(hydroxamic acid) (HoxH(2)) is prepared by reaction of 2,2'-biphenyldiacetyl chloride with 2 equiv of N-methylhydroxylamine. Use of 1 equiv of CH(3)NHOH gives the cyclic diacylhydroxylamine, which is selectively ring-opened to give a mixed monohydroxamate-monodiketonate ligand HobH(2). Both ligands are metalated
Natcharee, Kongprakaiwoot +2 more
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3-Hydroxyisoxazole-5-hydroxamic acid
Journal of Medicinal Chemistry, 1977The synthesis of the title compound, 3-hydroxyisoxazole-5-hydroxamic acid (4b), by two procedures is described. The first, involving the treatment of dimethyl acetylenedicarboxylate with hydroxylamine, had previously been reported to give the 3-hydroxyisoxazole-5-carboxylic acid (4a).
J W, Hines, C H, Stammer
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Hydroxamic acid oxidation-pharmacological considerations
Biochemical Pharmacology, 1978Abstract Both primary and secondary hydroxamic acids were found to be quite susceptible to oxidation by 2,6-dichlorophenolindophenol at physiological pH. Among the primary hydroxamates, substituted benzhydroxamic acids were more easily oxidized than aliphatic derivatives, resonance being an important factor determining relative rates.
S H, Blobstein +3 more
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Ternary Ligand−Zinc−Hydroxamate Complexes
Inorganic Chemistry, 2004Because of the importance of the hydroxamic acid functional group in zinc protease inhibitors, we have measured the stability constants of the ternary complex LMG, where L is series of tridentate and tetradentate ligands containing amino, carboxylate, pyridyl, and/or imidazolyl groups as enzyme models and G is the guest molecule, acetohydroxamate or N ...
Yu-Hung, Chiu +2 more
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1969
Publisher Summary This chapter summarizes the methods available for the synthesis of cyclic hydroxamic acids––to outline their characteristic reactions, and to present some useful physical data. Their synthesis, some biological and physical properties are also reviewed.
J.B. Bapat, D.S.T.C. Black, R.F.C. Brown
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Publisher Summary This chapter summarizes the methods available for the synthesis of cyclic hydroxamic acids––to outline their characteristic reactions, and to present some useful physical data. Their synthesis, some biological and physical properties are also reviewed.
J.B. Bapat, D.S.T.C. Black, R.F.C. Brown
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The Journal of Organic Chemistry, 2009
A continuous flow tubing reactor can be used to readily transform methyl or ethyl carboxylic esters into the corresponding hydroxamic acids. Flow rate, reactor volume, and temperature were optimized for the preparation of a small collection of hydroxamic acids. Synthetic advantages were identified as an increased reaction rate and higher product purity.
E. Riva +6 more
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A continuous flow tubing reactor can be used to readily transform methyl or ethyl carboxylic esters into the corresponding hydroxamic acids. Flow rate, reactor volume, and temperature were optimized for the preparation of a small collection of hydroxamic acids. Synthetic advantages were identified as an increased reaction rate and higher product purity.
E. Riva +6 more
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Hydroxamate Flotation of Malachite
Canadian Metallurgical Quarterly, 1979AbstractThe point of zero charge (PZC) of malachite has been determined to be pH 7.9, which is found to correspond closely to the weighted average of EP(Cu2+, HCO3−) and EP(CuOH+ , Cu(OH) 3−) of the malachite-water-air system. The hydroxamate flotation of malachite is effective between pH 6 and 10, a region in which HCO3− and CuOH+ ions are the ...
J. Lenormand, T. Salman, R. H. Yoon
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Infrared and Raman Spectroscopy Study of Alkyl Hydroxamic Acid and Alkyl Hydroxamate Isomers
Applied Spectroscopy, 2006The isomeric structures of alkyl hydroxamic acid, as well as its potassium salt, sodium salt, and an alcohol complex, have been characterized in the solid, liquid, and gaseous states by Fourier transform infrared (FT-IR) and FT-Raman spectroscopy.
Franklin S, Higgins +2 more
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