Results 11 to 20 of about 19,186 (210)
Evolution of lysine and arginine biosynthesis revealed by substrate specificity of lysine biosynthetic enzymes in Thermus thermophilus. [PDF]
FEBS JTwo enzymes from the Thermus thermophilus lysine biosynthetic pathway, LysZ and LysY, unexpectedly exhibit substrate promiscuity. They are able to recognize the LysW intermediates utilized by the ArgW‐mediated arginine route, even though the bacterium already possesses the canonical arginine biosynthetic pathway.
Shi W, Yoshida A, Kosono S, Nishiyama M.
europepmc +2 more sources
Matrix Metalloproteinase Inhibition in Melanoma. [PDF]
Exp DermatolABSTRACT Matrix metalloproteinases (MMPs) are involved in the degradation of the extracellular matrix (ECM) and are found to participate in all stages of tumour progression including modifying signalling pathways, regulating cytokines and promoting tumour growth, particularly by inducing angiogenesis and facilitating cancer spread.
Zhang E, Thakur V, Bedogni B.
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Hydroxamate Recognition During Iron Transport from Hydroxamate-Iron Chelates [PDF]
Journal of Bacteriology, 1973 Kinetics of radioactive iron transport from three structurally different secondary hydroxamate-iron chelates (schizokinen-iron, produced by Bacillus megaterium ATCC 19213; Desferal-iron, produced by an actinomycete; and aerobactin-iron, produced by Aerobacter aerogenes 62-1) revealed that
A H, Haydon +3 more
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Crystal structure of bis(pivaloylhydroxamato-κ2O,O′)copper(II)
Acta Crystallographica Section E: Crystallographic Communications, 2018 Reaction of copper(II) nitrate with pivaloylhydroxamic acid yielded the title compound, [Cu(pivHA)2] (where pivHA− is pivaloyl hydroxamate, C5H10NO2).
Kateryna Goleva +4 more
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Hydroxamic Acid as a Potent Metal-Binding Group for Inhibiting Tyrosinase
Antioxidants, 2022 Tyrosinase, a metalloenzyme containing a dicopper cofactor, plays a central role in synthesizing melanin from tyrosine. Many studies have aimed to identify small-molecule inhibitors of tyrosinase for pharmaceutical, cosmetic, and agricultural purposes ...
Joonhyeok Choi +3 more
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Drug-induced stress granule formation protects sensory hair cells in mouse cochlear explants during ototoxicity [PDF]
, 2019 Stress granules regulate RNA translation during cellular stress, a mechanism that is generally presumed to be protective, since stress granule dysregulation caused by mutation or ageing is associated with neurodegenerative disease.
Dawson, Sally J. +6 more
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Non-Hydroxamate Histone Deacetylase Inhibitors [PDF]
Current Medicinal Chemistry, 2005 A number of histone deacetylase (HDAC) inhibitors have been developed as anticancer agents and most of them are hydroxamic acid derivatives, typified by suberoylanilide hydroxamic acid (SAHA), Trichostatin A (TSA) and NVP-LAQ824. However, hydroxamic acids have been associated with poor pharmacokinetics and severe toxicity. In addition, although isozyme-
Takayoshi, Suzuki, Naoki, Miyata
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Fate of Labeled Hydroxamates During Iron Transport from Hydroxamate-Iron Chelates [PDF]
Journal of Bacteriology, 1973 The fate of the hydroxamic acid-iron transport cofactors during iron uptake from the 59 Fe 3+ chelates of the 3 H-labeled hydroxamates schizokinen and aerobactin was studied by assay of simultaneous incorporation of both 59 Fe 3+
J E, Arceneaux +4 more
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fac-Tris(4-aminobenzohydroxamato)iron(III) ethanol solvate
Acta Crystallographica Section E, 2010 In the structure of the title compound, [Fe(C7H7N2O2)3]·CH3CH2OH, the FeIII atom is in a distorted octahedral O6 environment with the three hydroxamate O atoms (and the three carbonyl O atoms) arranged in a fac configuration and one of the ...
Ahmed B. M. Alagha +4 more
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From Zn to Mn: the study of novel manganese-binding groups in the search for new drugs against tuberculosis. [PDF]
, 2011 In most eubacteria, apicomplexans, and most plants, including the causal agents for diseases such as malaria, leprosy, and tuberculosis, the methylerythritol phosphate pathway is the route for the biosynthesis of the C(5) precursors to the essential ...
de Oliveira, César Augusto F +3 more
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