Results 31 to 40 of about 19,186 (210)
Computational study of radicals derived from hydroxyurea and its methylated analogues. [PDF]
, 2012 Structural and electronic properties and chemical fate of free radicals generated from hydroxyurea (HU) and its methylated analogues N-methylhydroxyurea (NMHU) and O-methylhydroxyurea (OMHU) are of utmost importance for their biological and ...
Birus, Mladen +4 more
core +1 more source
Carbon- versus sulphur-based zinc binding groups for carbonic anhydrase inhibitors?
Journal of Enzyme Inhibition and Medicinal Chemistry, 2018 A set of compounds incorporating carbon-based zinc-binding groups (ZBGs), of the type PhX (X = COOH, CONH2, CONHNH2, CONHOH, CONHOMe), and the corresponding derivatives with sulphur(VI)-based ZBGs (X = SO3H, SO2NH2, SO2NHNH2, SO2NHOH, SO2NHOMe) were ...
Claudiu T. Supuran
doaj +1 more source
Frontiers in Cellular and Infection Microbiology, 2020 Scedosporium species rank second among the filamentous fungi capable to colonize chronically the respiratory tract of patients with cystic fibrosis (CF). Nevertheless, there is little information on the mechanisms underpinning their virulence.
Yohann Le Govic +12 more
doaj +1 more source
Inhibitory antibodies designed for matrix metalloproteinase modulation [PDF]
, 2019 The family of matrix metalloproteinases (MMPs) consists of a set of biological targets that are involved in a multitude of severe pathogenic events such as different forms of cancers or arthritis.
Fischer, Thomas, Riedl, Rainer
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Tạp chí Khoa học Đại học Cần Thơ, 2020 Belinostat là thuốc có khả năng ức chế enzyme HDAC khá tốt, được sử dụng điều trị các khối u ác tính về huyết học và khối u rắn. Trong nghiên cứu này, các dẫn xuất tương tự belinostat đã được tổng hợp thành công qua quy trình đơn giản và hiệu quả, phù ...
Nguyễn Cường Quốc +12 more
doaj +1 more source
Structures of Staphylococcus aureus peptide deformylase in complex with two classes of new inhibitors [PDF]
, 2012 Peptide deformylase (PDF) catalyzes the removal of the formyl group from the N-terminal methionine residue in newly synthesized polypeptides, which is an essential process in bacteria.
Il Lee, B. +7 more
core +1 more source
Journal of Pharmacy and Pharmacology, 1964 Abstract The preparation of certain quinolines, quinazolines, quinoxalines, benzoxazines and benzothiazines containing the cyclic hydroxamic grouping is described. In vitro antibacterial activities showed that no compound had a broader spectrum of activity than the known 1,2-dihydro-1-hydroxy-2-oxoquinoline.
R T, COUTTS, D, NOBLE, D G, WIBBERLEY
openaire +2 more sources
Effects of CO2 enrichment on photosynthesis, growth, and nitrogen metabolism of the seagrass Zostera noltii [PDF]
, 2012 Seagrass ecosystems are expected to benefit from the global increase in CO2 in the ocean because the photosynthetic rate of these plants may be C-i-limited at the current CO2 level.
Alexandre +56 more
core +1 more source
Molecules, 2019 A series of novel coumarin-based hydroxamate derivatives were designed and synthesized as histone deacetylase inhibitors (HDACis). Selective compounds showed a potent HDAC inhibition with nM IC50 values, with the best compound (10e) being nearly 90 times
Feifei Yang +6 more
doaj +1 more source
Non-Hydroxamate Zinc-Binding Groups as Warheads for Histone Deacetylases
Molecules, 2021 Histone deacetylases (HDACs) remove acetyl groups from acetylated lysine residues and have a large variety of substrates and interaction partners. Therefore, it is not surprising that HDACs are involved in many diseases. Most inhibitors of zinc-dependent
Anton Frühauf, Franz-Josef Meyer-Almes
doaj +1 more source