Results 41 to 50 of about 19,186 (210)

The Landscape of Realized Homologous Recombination in Pathogenic Bacteria [PDF]

, 2015
Recombination enhances the adaptive potential of organisms by allowing genetic variants to be tested on multiple genomic backgrounds. Its distribution in the genome can provide insight into the evolutionary forces that underlie traits, such as the ...
Didelot, X, Falush, D, Jolley, KA, Kobayashi, I, Maiden, MCJ, Sheppard, SK, Yahara, K   +6 more
core   +2 more sources

Design, synthesis, and biological evaluation of substituted benzyl-triazolopyridine derivatives as non-hydroxamate based HDAC8 inhibitors

European Journal of Medicinal Chemistry Reports
Traditional Histone deacetylase 8 (HDAC8) inhibitors primarily rely on hydroxamate-based scaffolds. However, there is a growing interest in developing non-hydroxamate inhibitors to overcome potential limitations with hydroxamate-based inhibitors. In this
N.V.M. Rao Bandaru, Ashna Fathima, Vandana Joshi, Markus Schweipert, Obanna Pathur, Kosana Sai Chaitanya, Trinath Jamma, Vivek Sharma, Chandrasekhar Abbineni, Franz-Josef Meyer-Almes, Kondapalli Venkata Gowri Chandra Sekhar   +10 more
doaj   +1 more source

Regulated Iron Siderophore Production of the Halophilic Archaeon Haloferax volcanii

Biomolecules, 2020
Iron is part of many redox and other enzymes and, thus, it is essential for all living beings. Many oxic environments have extremely low concentrations of free iron.
Natalie Niessen, Jörg Soppa
doaj   +1 more source

Hydroxamate production by Aquaspirillum magnetotacticum [PDF]

Journal of Bacteriology, 1986
Spent culture fluids from Aquaspirillum magnetotacticum MS-1 grown at high (20 microM) but not low (5 microM) iron concentration contained material yielding a positive hydroxamate test. Cells possessed six major outer membrane proteins. Three outer membrane proteins ranging from 72,000 to 85,000 daltons were coordinately produced at iron concentrations
L C, Paoletti, R P, Blakemore
openaire   +2 more sources

AMPHIPHILIC SIDEROPHORE MARINOBACTIN FOR FROTH FLOTATION PROCESS [PDF]

, 2018
The consumption of metallic raw materials increased in the last years. The coverage of demand is getting more difficult, because both primary and secondary raw materials become more and more complex. To find a solution, some new
Kutschke, Sabine, Pollmann, Katrin, Rudolph, Martin, Schrader, Sylvi   +3 more
core   +2 more sources

Isolation and Bioactivity of Natural Products from Streptomyces sp. MA37

Molecules
The isolation and characterization of bioactive metabolites from Streptomyces species continue to represent a vital area of research, given their potential in natural product drug discovery.
Fleurdeliz Maglangit, Qing Fang, Jioji N. Tabudravu, Kwaku Kyeremeh, Marcel Jaspars, Hai Deng   +5 more
doaj   +1 more source

Novel South African Rare Actinomycete Kribbella speibonae Strain SK5: A Prolific Producer of Hydroxamate Siderophores Including New Dehydroxylated Congeners

Molecules, 2020
In this paper, we report on the chemistry of the rare South African Actinomycete Kribbella speibonae strain SK5, a prolific producer of hydroxamate siderophores and their congeners. Two new analogues, dehydroxylated desferrioxamines, speibonoxamine 1 and
Kojo Sekyi Acquah, Denzil R. Beukes, Digby F. Warner, Paul R. Meyers, Suthananda N. Sunassee, Fleurdeliz Maglangit, Hai Deng, Marcel Jaspars, David W. Gammon   +8 more
doaj   +1 more source

Orally Active MMP-1 Sparing α-tetrahydropyranyl and α-piperidinyl Sulfone Matrix Metalloproteinase (MMP) Inhibitors with Efficacy in Cancer, Arthritis, and Cardiovascular Disease [PDF]

, 2010
α-Sulfone-α-piperidine and α-tetrahydropyranyl hydroxamates were explored that are potent inhibitors of MMP’s-2, -9, and -13 that spare MMP-1, with oral efficacy in inhibiting tumor growth in mice and left-ventricular hypertrophy in rats and in the ...
Barta, Thomas E., Becker, Daniel P, Bedell, Louis J., Boehm, Terri L.   +3 more
core   +1 more source

Pseudomonas siderophores: production, spectrophotometry detection and Botrytis suppression

Notulae Scientia Biologicae
Siderophores are iron-chelating agents produced by almost all microorganisms in response to iron deficiency. Due to the requirement of iron for cell growth and metabolism, siderophore-mediated acquisition of iron plays a central role in determining the ...
Redouan QESSAOUI, Mohamed ELAAlAOUI, Salahddine CHAFIKI, Mohamed ALOUANI, Naima CHABBI, Naima AIT ABD, Abdelghani TAHIRI, Rachid BOUHARROUD   +7 more
doaj   +1 more source

Flow cytometry-based study of model marine microalgal consortia revealed an ecological advantage of siderophore utilization by the dinoflagellate Amphidinium carterae

Computational and Structural Biotechnology Journal, 2022
Investigations of phytoplankton responses to iron stress in seawater are complicated by the fact that iron concentrations do not necessarily reflect bioavailability.
Ronald Malych, Pavel Stopka, Jan Mach, Eva Kotabová, Ondřej Prášil, Robert Sutak   +5 more
doaj   +1 more source