Results 61 to 70 of about 19,186 (210)

ADAM17 and its proteolytic targets in disease pathogenesis

The FEBS Journal, EarlyView.
ADAM17 as a multifunctional sheddase with contrasting roles across inflammatory, metabolic, cardiovascular, and neoplastic diseases. Through regulated activation by iRhom, iTAP/FRMD8, and tetraspanins, ADAM17 cleaves diverse membrane ligands and receptors, thereby promoting inflammation, fibrosis, obesity, insulin resistance, and tumor progression ...
Abdulbasit Amin, Marina Badenes
wiley   +1 more source

Tripeptide hydroxamate from Corynebacterium kutscheri [PDF]

Journal of Bacteriology, 1979
A tripeptide hydroxamate was isolated from cultures of Corynebacterium kutscheri grown on an iron-limiting medium. The metabolite was characterized by spectral measurements and by chemical degradation as L-alpha-aspartyl-L-alpha-N-hydroxy-aspartyl-D-cycloserine.
W G, McCullough, R S, Merkal
openaire   +2 more sources

Molecular Mechanisms of Algicidal Bacteria in Controlling Harmful Algal Blooms: Advances in Bacteria‐Algae Interactions

Environmental Microbiology Reports, Volume 18, Issue 2, April 2026.
This review elucidates the molecular mechanisms of algicidal bacteria, highlighting critical behaviours like chemotaxis, quorum sensing and extracellular vesicle release. It details how these actions disrupt algal cellular integrity, photosynthesis and calcium homeostasis, providing a theoretical foundation for controlling harmful algal blooms ...
Jiaxin Wang, Binfu Xu, Lixing Huang
wiley   +1 more source

Synthesis, Characterization, X-Ray Crystal Structures and Antibacterial Activities of Oxidovanadium(V) Complexes with Hydrazone and Hydroxamate Ligands

Acta Chimica Slovenica, 2019
Two new oxidovanadium(V) complexes, [VOL1L] (1) and [VOL2L]·CH3OH (2·CH3OH), where L1 and L2 are the dianionic form of N’-(3-bromo-2-hydroxybenzylidene)picolinohydrazide (H2L1) and 2-chloro-N’-(2-hydroxy-3-methoxybenzylidene)benzohydrazide (H2L2 ...
Heng-Yu Qian
doaj   +1 more source

Mining microbial genomes for new natural products and biosynthetic pathways [PDF]

, 2008
Analyses of microbial genome sequences have revealed numerous examples of ‘cryptic’ or ‘orphan’ biosynthetic gene clusters, with the potential to direct the production of novel, structurally complex natural products.
Austin, Austin, Banskota, Banskota, Barona-Gómez, Barona-Gómez, Bentley, Bergmann, Bok, Caffrey, Chain, Challis, Challis, Challis, Challis, Chen, Chen, Corre, de Bruijn, Drake, Erb, Fischbach, Fleischmann, Fleming, Funa, Gregory L. Challis, Gross, Gross, Grüschow, Gust, Günter, Haydock, Haynes, Hojati, Hornung, Ikeda, Izumikawa, Kadi, Keller, Koehn, Larsen, Lautru, Lautru, Li, Li, Lin, Lin, McAlpine, Miethke, Minowa, Miyanaga, Muller, Nguyen, Oliynyk, Omura, Paulsen, Petersen, Pfeifer, Rausch, Reid, Song, Stachelhaus, Sudek, Tohyama, Udwary, Wilkinson, Zhao, Zirkle   +67 more
core   +2 more sources

Investigation of Plant Growth Promotion Potential of Novel Compost‐Derived Bacilli and Anticipating Their In Vivo Effectiveness Through Mathematical Modelling

Environmental Microbiology Reports, Volume 18, Issue 2, April 2026.
Compost derived Bacillus isolates were screened for plant growth promoting traits, scored through modelling and validated in field trials on maize and okra. Selected strains enhanced growth significantly, enabling reduced chemical fertiliser use, ecofriendly bioinputs and improved soil health.
Debapriya Maitra, Bedaprana Roy, Bikram Dhara, Archisman Chakraborti, Indranath Chaudhuri, Ranadhir Chakraborty, Sudeshna Shyam Choudhury, Swastika Maitra, Ajoy Kumer, Arup Kumar Mitra   +9 more
wiley   +1 more source

WMJ-S-001, a Novel Aliphatic Hydroxamate-Based Compound, Suppresses Lymphangiogenesis Through p38mapk-p53-survivin Signaling Cascade

Frontiers in Oncology, 2019
Background and purpose: Angiogenesis and lymphangiogenesis are major routes for metastatic spread of tumor cells. It thus represent the rational targets for therapeutic intervention of cancer.
Shiu-Wen Huang, Shiu-Wen Huang, Hung-Yu Yang, Hung-Yu Yang, Wei-Jan Huang, Wei-Chuan Chen, Meng-Chieh Yu, Shih-Wei Wang, Shih-Wei Wang, Ya-Fen Hsu, Ming-Jen Hsu, Ming-Jen Hsu   +11 more
doaj   +1 more source

Structure of Mandelate Racemase with Bound Intermediate Analogues Benzohydroxamate and Cupferron [PDF]

, 2012
Mandelate racemase (MR, EC 5.1.2.2) from Pseudomonas putida catalyzes the Mg2+-dependent interconversion of the enantiomers of mandelate, stabilizing the altered substrate in the transition state by 26 kcal/mol relative to the substrate in the ground ...
Bearne, Stephen L., Bourque, Jennifer R., Lietzan, Adam D., Maurice, Martin St., Nagar, Mitesh, Pellmann, Elisa   +5 more
core   +2 more sources

Making Blank Faces Expressive: Chemical Approaches to the Modification of Chemically Inert Peptides

Journal of Peptide Science, Volume 32, Issue 3, March 2026.
As an alternative to the conventional approach, which combines amino acid monomers in a one‐by‐one fashion to peptide derivatives, the chemical modification of existing peptides has attracted significant attention in recent years. However, such approaches generally target the reactive functional groups in cysteine and lysine residues, particularly in ...
Yoshitaka Moriyama, Hikari Sada, Takeshi Nanjo   +2 more
wiley   +1 more source

Crystal structure of poly[(μ3-4-amino-1,2,5-oxadiazole-3-hydroxamato)thallium(I)]

Acta Crystallographica Section E: Crystallographic Communications, 2020
The title compound represents the thallium(I) salt of a substituted 1,2,5-oxadiazole, [Tl(C3H3N4O3)]n, with amino- and hydroxamate groups in the 4- and 3- positions of the oxadiazole ring, respectively.
Inna S. Safyanova, Oksana A. Bondar, Anna V. Pavlishchuk, Iryna V. Omelchenko, Turganbay S. Iskenderov, Valentina A. Kalibabchuk   +5 more
doaj   +1 more source