Results 71 to 80 of about 19,186 (210)

[(?6 -p-cymene)Ru(H2O)3] 2+ Binding Capability of Aminohydroxamates - A Solution and Solid State Study [PDF]

, 2018
L
Buglyó, Péter, Bényei, Attila, Kasparkova, Jana, Kováts, Éva, Novohradsky, Vojtech, Parajdi-Losonczi, Péter László, Radosova Muchova, Tereza, Timári, István   +7 more
core   +1 more source

Leveraging the ADAM10 prodomain for selective inhibition to enhance recovery after myocardial infarction

British Journal of Pharmacology, Volume 183, Issue 5, Page 990-1008, March 2026.
Background and Purpose Inflammation plays a crucial role in the development and progression of numerous acute and chronic diseases such as myocardial infarction (MI) and heart failure. Targeting ADAM proteases, particularly ADAM10, holds promise for fine‐tuning inflammatory responses.
Erik Klapproth, Johanna Marks, Patrick Diaba‐Nuhoho, Sören Grell, Paul Leubauer, Susanne Kämmerer, Johannes R. Soltwedel, Fred Rasmussen, Felix Mejia, Marcia L. Moss, Christopher Prince, Peter Mirtschink, Ben Wielockx, Paul Saftig, Michael Wagner, Kristina Lorenz, Ali El‐Armouche   +16 more
wiley   +1 more source

Opportunities and Difficulties in the Repurposing of HDAC Inhibitors as Antiparasitic Agents

Drugs and Drug Candidates
Ongoing therapy for human parasite infections has a few known drugs but with serious side effects and the problem of drug resistance, impelling us to discover novel drug candidates with newer mechanisms of action.
Tapas Kumar Mohapatra, Reena Rani Nayak, Ankit Ganeshpurkar, Prashant Tiwari, Dileep Kumar   +4 more
doaj   +1 more source

Effect of salinity on the zinc(II) binding efficiency of siderophore functional groups and implications for salinity tolerance mechanisms in barley

Scientific Reports, 2021
Bacteria, fungi and grasses use siderophores to access micronutrients. Hence, the metal binding efficiency of siderophores is directly related to ecosystem productivity.
George H. R. Northover, Yiru Mao, Haris Ahmed, Salvador Blasco, Ramon Vilar, Enrique Garcia-España, Dominik J. Weiss   +6 more
doaj   +1 more source

The inhibitory effect of newly synthesized guar, chitosan and cellulose resins on the growth of pathogenic bacteria [PDF]

, 2015
Guar, Chitosan and Cellulose based new chelating ionexchangeresins were synthesized. The inhibitory activity of Chitosan triazine phenyl alanine hydroxamate [CT-PAH],Guar-triazine phenyl alanine hydroxamate [GT-PAH], Celluloseepoxy leucine hydroxamate ...
Dadhich, Kamodini, Loonker, Sangeeta, Singh, Jasmine   +2 more
core  

Factors Influencing the Diversity of Iron Uptake Systems in Aquatic Microorganisms [PDF]

, 2012
Iron (Fe) is an essential micronutrient for many processes in all living cells. Dissolved Fe (dFe) concentrations in the ocean are of the order of a few nM, and Fe is often a factor limiting primary production.
Desai, Dhwani K., Desai, Falguni D., LaRoche, Julie   +2 more
core   +2 more sources

Production, characterization and iron binding affinity of hydroxamate siderophores from rhizosphere associated fluorescent Pseudomonas

Journal of Plant Protection Research, 2018
Fluorescent Pseudomonas (FP) is a major group of plant growth promoting rhizobacteria and a well-known synthesizer of siderophores, which imparts a selective advantage on rhizosphere competence and their biocontrol traits.
Monali Deori, Nellickal Subramanyan Jayamohan, Belur Satyan Kumudini   +2 more
doaj   +1 more source

1,3-Diphenylureido hydroxamate as a promising scaffold for generation of potent antimalarial histone deacetylase inhibitors

Scientific Reports, 2023
We report a series of 1,3-diphenylureido hydroxamate HDAC inhibitors evaluated against sensitive and drug-resistant P. falciparum strains. Compounds 8a–d show potent antiplasmodial activity, indicating that a phenyl spacer allows improved potency ...
Maurício T. Tavares, Arne Krüger, Sun L. Rei Yan, Karoline B. Waitman, Vinícius M. Gomes, Daffiny Sumam de Oliveira, Franciarli Paz, Sebastian Hilscher, Mike Schutkowski, Wolfgang Sippl, Claudia Ruiz, Mônica F. Z. J. Toledo, Neuza M. A. Hassimotto, João A. Machado-Neto, Antti Poso, Michael D. Cameron, Thomas D. Bannister, Giuseppe Palmisano, Carsten Wrenger, Thales Kronenberger, Roberto Parise-Filho   +20 more
doaj   +1 more source

Design, Synthesis, Bioactivity Evaluation, Crystal Structures, and In Silico Studies of New α-Amino Amide Derivatives as Potential Histone Deacetylase 6 Inhibitors

Molecules, 2022
Hydroxamate, as a zinc-binding group (ZBG), prevails in the design of histone deacetylase 6(HDAC6) inhibitors due to its remarkable zinc-chelating capability.
Yangrong Xu, Hangjun Tang, Yijie Xu, Jialin Guo, Xu Zhao, Qingguo Meng, Junhai Xiao   +6 more
doaj   +1 more source

Neurogenesis and the Epigenetic Landscape: Role of Histone Modifications and Chromatin Remodeling

Brain and Behavior, Volume 16, Issue 2, February 2026.
Histone methylation and acetylation modulate gene expression by inducing chromatin condensation or relaxation, which in turn regulates transcriptional activity and impacts neurogenesis. ABSTRACT Aims The purpose of this review is to examine how epigenetic regulation particularly chromatin modification and histone methylation controls gene expression ...
Degisew Yinur Mengistu, Biniam Moges Eskeziyaw   +1 more
wiley   +1 more source