Novel Multitarget Hydroxamic Acids with a Natural Origin CAP Group against Alzheimer’s Disease: Synthesis, Docking and Biological Evaluation [PDF]
Pharmaceutics, 2021 Hydroxamic acids are one of the most promising and actively studied classes of chemical compounds in medicinal chemistry. In this study, we describe the directed synthesis and effects of HDAC6 inhibitors.
Margarita Neganova +10 more
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Antimycobacterial Activities of Hydroxamic Acids and Their Iron(II/III), Nickel(II), Copper(II) and Zinc(II) Complexes [PDF]
Microorganisms, 2023 Hydroxamic acid (HA) derivatives display antibacterial and antifungal activities. HA with various numbers of carbon atoms (C2, C6, C8, C10, C12 and C17), complexed with different metal ions, including Fe(II/III), Ni(II), Cu(II) and Zn(II), were evaluated
Dong Yang +10 more
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Oxidative cycloaddition of hydroxamic acids with dienes or guaiacols mediated by iodine(III) reagents [PDF]
Beilstein Journal of Organic Chemistry, 2018 [Bis(trifluoroacetoxy)iodo]benzene (BTI) and (diacetoxyiodo)benzene (DIB) efficiently promote the formation of acylnitroso species from hydroxamic acids in the presence of various dienes to give the corresponding hetero-Diels–Alder (HDA) adducts in ...
Hisato Shimizu +5 more
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Alternating Current Electrolysis as Efficient Tool for the Direct Electrochemical Oxidation of Hydroxamic Acids for Acyl Nitroso Diels-Alder Reactions. [PDF]
Angew Chem Int Ed Engl, 2021 The acyl nitroso Diels–Alder reaction of 1,3‐dienes with electrochemically oxidised hydroxamic acids is described. By using alternating current electrolysis, their typical electro‐induced decomposition could be suppressed in favour of the 1,2‐oxazine ...
Fährmann J, Hilt G.
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Synthesis and HDAC inhibitory activity of pyrimidine-based hydroxamic acids [PDF]
Beilstein Journal of Organic Chemistry, 2022 Histone deacetylases (HDACs) play an essential role in the transcriptional regulation of cells through the deacetylation of nuclear histone and non-histone proteins and are promising therapeutic targets for the treatment of various diseases.
Virginija Jakubkiene +6 more
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Hydroxamic Acids Immobilized on Resins (HAIRs): Synthesis of Dual-Targeting HDAC Inhibitors and HDAC Degraders (PROTACs). [PDF]
Angew Chem Int Ed Engl, 2020 Inhibition of more than one cancer‐related pathway by multi‐target agents is an emerging approach in modern anticancer drug discovery. Here, based on the well‐established synergy between histone deacetylase inhibitors (HDACi) and alkylating agents, we ...
Sinatra L +11 more
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Design, Synthesis, and Biological Evaluation of Quinazolin-4-one-Based Hydroxamic Acids as Dual PI3K/HDAC Inhibitors. [PDF]
J Med Chem, 2020 A series of quinazolin-4-one based hydroxamic acids was rationally designed and synthesized as novel dual PI3K/HDAC inhibitors by incorporating an HDAC pharmacophore into a PI3K inhibitor (Idelalisib) via an optimized linker.
Thakur A +14 more
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Diversity in the Interaction of Amino Acid- and Peptide-Based Hydroxamic Acids with Some Platinum Group Metals in Solution [PDF]
Molecules, 2022 Complexes that incorporate both ligand(s) and metal(s) exhibiting cytotoxic activity can especially be interesting to develop multifunctional drug molecules with desired activities.
Linda Bíró +2 more
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Development of QSRR model for hydroxamic acids using PCA-GA-BP algorithm incorporated with molecular interaction-based features [PDF]
Frontiers in Chemistry, 2022 As a potent zinc chelator, hydroxamic acid has been applied in the design of inhibitors of zinc metalloenzyme, such as histone deacetylases (HDACs). A series of hydroxamic acids with HDAC inhibitory activities were subjected to the QSRR (Quantitative ...
Yiming Nie +4 more
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Hydrophobic Flocculation of Fine Cassiterite Using Alkyl Hydroxamic Acids with Different Carbon Chain Lengths as Collectors [PDF]
Molecules, 2023 This work investigated the hydrophobic flocculation of cassiterite using four alkyl hydroxamic acids with varying carbon chain lengths, i.e., hexyl hydroxamate (C6), octyl hydroxamate (C8), decyl hydroxamate (C10) and dodecyl hydroxamate (C12), as ...
Saizhen Jin, Qing Shi, Leming Ou
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