Synthesis and HDAC inhibitory activity of pyrimidine-based hydroxamic acids [PDF]
Beilstein Journal of Organic Chemistry, 2022 Histone deacetylases (HDACs) play an essential role in the transcriptional regulation of cells through the deacetylation of nuclear histone and non-histone proteins and are promising therapeutic targets for the treatment of various diseases.
Virginija Jakubkiene +6 more
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Novel Multitarget Hydroxamic Acids with a Natural Origin CAP Group against Alzheimer’s Disease: Synthesis, Docking and Biological Evaluation [PDF]
Pharmaceutics, 2021 Hydroxamic acids are one of the most promising and actively studied classes of chemical compounds in medicinal chemistry. In this study, we describe the directed synthesis and effects of HDAC6 inhibitors.
Margarita Neganova +10 more
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Enzymatic Synthesis of Fatty Hydroxamic Acid Derivatives Based on Palm Kernel Oil [PDF]
Molecules, 2011 Fatty hydroxamic acid derivatives were synthesized using Lipozyme TL IM catalyst at biphasic medium as the palm kernel oil was dissolved in hexane and hydroxylamine derivatives were dissolved in water: (1) N-methyl fatty hydroxamic acids (MFHAs); (2) N ...
Sidik Silong +7 more
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A Comparative Study of C2-Symmetric and C1-Symmetric Hydroxamic Acids in Vanadium-Catalyzed Asymmetric Epoxidation of Allylic Alcohols [PDF]
MoleculesHydroxamic acids are emerging as versatile chiral ligands for metal-catalyzed asymmetric oxidations due to their tunable electronic and steric environments.
Marco Valtierra-Galván +6 more
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Diversity in the Interaction of Amino Acid- and Peptide-Based Hydroxamic Acids with Some Platinum Group Metals in Solution [PDF]
Molecules, 2022 Complexes that incorporate both ligand(s) and metal(s) exhibiting cytotoxic activity can especially be interesting to develop multifunctional drug molecules with desired activities.
Linda Bíró +2 more
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Development of QSRR model for hydroxamic acids using PCA-GA-BP algorithm incorporated with molecular interaction-based features [PDF]
Frontiers in Chemistry, 2022 As a potent zinc chelator, hydroxamic acid has been applied in the design of inhibitors of zinc metalloenzyme, such as histone deacetylases (HDACs). A series of hydroxamic acids with HDAC inhibitory activities were subjected to the QSRR (Quantitative ...
Yiming Nie +4 more
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Hydrophobic Flocculation of Fine Cassiterite Using Alkyl Hydroxamic Acids with Different Carbon Chain Lengths as Collectors [PDF]
Molecules, 2023 This work investigated the hydrophobic flocculation of cassiterite using four alkyl hydroxamic acids with varying carbon chain lengths, i.e., hexyl hydroxamate (C6), octyl hydroxamate (C8), decyl hydroxamate (C10) and dodecyl hydroxamate (C12), as ...
Saizhen Jin, Qing Shi, Leming Ou
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Facile Access to Fe(III)-Complexing Cyclic Hydroxamic Acids in a Three-Component Format [PDF]
Molecules, 2019 Cyclic hydroxamic acids can be viewed as effective binders of soluble iron and can therefore be useful moieties for employing in compounds to treat iron overload disease.
Evgeny Chupakhin +3 more
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Hydroxamic acids in asymmetric synthesis. [PDF]
Acc Chem Res, 2013 Metal-catalyzed stereoselective reactions are a central theme in organic chemistry research. In these reactions, the stereoselection is achieved predominantly by introducing chiral ligands at the metal catalyst's center. For decades, researchers have sought better chiral ligands for asymmetric catalysis and have made great progress.
Li Z, Yamamoto H.
europepmc +4 more sources
Utilization of Lead Nitrate to Enhance the Impact of Hydroxamic Acids on the Hydrophobic Aggregation and Flotation Behavior of Cassiterite [PDF]
MoleculesLead nitrate (LN) is frequently employed as an activator in the flotation of cassiterite using hydroxamic acids as the collectors. This study investigated the effect of LN on the hydrophobic aggregation of cassiterite when benzohydroxamic acid (BHA ...
Saizhen Jin +5 more
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