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Role of histone deacetylases in blood cancer: Exploring peptide‑based inhibitors as therapeutic strategies for leukemia treatment (Review). [PDF]
Oncol RepSuwanwong Y, Ploensil P.
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Acidity of hydroxamic acids and amides
Organic & Biomolecular Chemistry, 2003The relatively strong acidity of hydroxamic acids was analyzed by means of isodesmic reactions in which this acid or its anion is formed from simpler precursors. Acidity of amides was analyzed in the same way. Energies of all compounds involved in the reactions were calculated at the B3LYP/AUG-cc-pVTZ//B3LYP/6-311 + G(d,p) level; at this level a good ...
Stanislav, Böhm, Otto, Exner
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Journal of Polymer Science: Polymer Chemistry Edition, 1975
AbstractA polymer bearing hydroxamic acid groups and having a high affinity for iron(III) was prepared through the following procedure. Acryloylalanine (III), prepared by the reaction of acryloyl chloride with alanine, was treated with N‐hydroxysuccinimide in the presence of dicyclohexylcarbodiimide to give the N‐hydroxysuccinimide ester (IV).
Anthony Winston, Edward T. Mazza
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AbstractA polymer bearing hydroxamic acid groups and having a high affinity for iron(III) was prepared through the following procedure. Acryloylalanine (III), prepared by the reaction of acryloyl chloride with alanine, was treated with N‐hydroxysuccinimide in the presence of dicyclohexylcarbodiimide to give the N‐hydroxysuccinimide ester (IV).
Anthony Winston, Edward T. Mazza
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Hydroxamic Acids as Pharmacological Agents
Current Medicinal Chemistry, 2002A variety of hydroxamic acid derivatives have recently been touted for their potential use as inhibitors of hypertension, tumor growth, inflammation, infectious agents, asthma, arthritis, and more. Here we provide a comprehensive review of the basic medicinal chemistry and pharmacology of hydroxamic acid derivatives that have been examined as ...
Muri, Estela M.F. +3 more
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3-Hydroxyisoxazole-5-hydroxamic acid
Journal of Medicinal Chemistry, 1977The synthesis of the title compound, 3-hydroxyisoxazole-5-hydroxamic acid (4b), by two procedures is described. The first, involving the treatment of dimethyl acetylenedicarboxylate with hydroxylamine, had previously been reported to give the 3-hydroxyisoxazole-5-carboxylic acid (4a).
J W, Hines, C H, Stammer
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Hydroxamic acid oxidation-pharmacological considerations
Biochemical Pharmacology, 1978Abstract Both primary and secondary hydroxamic acids were found to be quite susceptible to oxidation by 2,6-dichlorophenolindophenol at physiological pH. Among the primary hydroxamates, substituted benzhydroxamic acids were more easily oxidized than aliphatic derivatives, resonance being an important factor determining relative rates.
S H, Blobstein +3 more
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Hydroxamic acids as colorimetric reagents
Talanta, 1966Thirty-three hydroxamic acids and three N-substituted hydroxamic acids or structurally similar compounds have been studied as possible colorimetric reagents for metal ions. They were tested with 78 ions under varying conditions of acidity and basicity.
V C, Bass, J H, Yoe
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