Results 161 to 170 of about 21,287 (222)

Palladium-catalysed synthesis of small-molecule epigenetic inhibitors as anticancer therapeutics. [PDF]

J Enzyme Inhib Med Chem
Sharma R, Rana M, Thakur A, Ojha R, Mousavi SM, Dhingra A, Nepali K.   +6 more
europepmc   +1 more source

Phosphatidylinositol-3-Kinase (PI3K) and Histone Deacetylase (HDAC) Multitarget Inhibitors: An Update on Clinical and Preclinical Candidates. [PDF]

Pharmaceuticals (Basel)
Lima ADS, Lima LM.
europepmc   +1 more source

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The Hydroxamic Acids.

Chemical Reviews, 1943
exaly   +2 more sources

Acidity of hydroxamic acids and amides

Organic & Biomolecular Chemistry, 2003
The relatively strong acidity of hydroxamic acids was analyzed by means of isodesmic reactions in which this acid or its anion is formed from simpler precursors. Acidity of amides was analyzed in the same way. Energies of all compounds involved in the reactions were calculated at the B3LYP/AUG-cc-pVTZ//B3LYP/6-311 + G(d,p) level; at this level a good ...
Stanislav, Böhm, Otto, Exner
openaire   +2 more sources

Hydroxamic Acids as Pharmacological Agents

Current Medicinal Chemistry, 2002
A variety of hydroxamic acid derivatives have recently been touted for their potential use as inhibitors of hypertension, tumor growth, inflammation, infectious agents, asthma, arthritis, and more. Here we provide a comprehensive review of the basic medicinal chemistry and pharmacology of hydroxamic acid derivatives that have been examined as ...
Muri, Estela M.F., Nieto, Marcelo J., Sindelar, Robert D., Williamson, John S.   +3 more
openaire   +3 more sources

Hydroxamic acids as colorimetric reagents

Talanta, 1966
Thirty-three hydroxamic acids and three N-substituted hydroxamic acids or structurally similar compounds have been studied as possible colorimetric reagents for metal ions. They were tested with 78 ions under varying conditions of acidity and basicity.
V C, Bass, J H, Yoe
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Efficient Continuous Flow Synthesis of Hydroxamic Acids and Suberoylanilide Hydroxamic Acid Preparation

The Journal of Organic Chemistry, 2009
A continuous flow tubing reactor can be used to readily transform methyl or ethyl carboxylic esters into the corresponding hydroxamic acids. Flow rate, reactor volume, and temperature were optimized for the preparation of a small collection of hydroxamic acids. Synthetic advantages were identified as an increased reaction rate and higher product purity.
E. Riva, S. Gagliardi, C. Mazzoni, D. Passarella, A. Rencurosi, D. Vigo, M. Martinelli   +6 more
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Hydroxamic acids I: Factors affecting the stability of the hydroxamic acid-iron complex

Journal of Pharmaceutical Sciences, 1969
The utility of hydroxamic acid formation and subsequent iron complexation as an analytical tool for succinimide has been investigated. Several factors affecting the stability of the hydroxamic acid-ferric iron complex have been studied and critical factors in the stability of the complex have been established.
R E, Notari, J W, Munson
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Antibiotics and other naturally occurring hydroxamic acids and hydroxamates

Pure and Applied Chemistry, 1971
Abstract
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