Results 31 to 40 of about 21,152 (225)

Identification and Characterization of AES-135, a Hydroxamic Acid-Based HDAC Inhibitor That Prolongs Survival in an Orthotopic Mouse Model of Pancreatic Cancer [PDF]

, 2019
Pancreatic ductal adenocarcinoma (PDAC) is an aggressive, incurable cancer with a 20% 1 year survival rate. While standard-of-care therapy can prolong life in a small fraction of cases, PDAC is inherently resistant to current treatments, and novel ...
Adile, Ashley A., Bakhshinyan, David, Berger-Becvar, Angelika, de Araujo, Elvin D., Deininger, Michael W., Fishel, Melissa L., Gawel, Justyna M., Geletu, Mulu, Grimard, Michelle L., Gunning, Patrick T., Heaton, William L., Konieczny, Stephen F., Luchman, H. Artee, O'Hare, Thomas, Raouf, Yasir, Shah, Fenil, Shouksmith, Andrew E., Singh, Sheila K., Venugopal, Chitra, Weiss, Samuel   +19 more
core   +3 more sources

A perspective on using experiment and theory to identify design principles in dye-sensitized solar cells [PDF]

, 2018
Dye-sensitized solar cells (DSCs) have been the subject of wide-ranging studies for many years because of their potential for large-scale manufacturing using roll-to-roll processing allied to their use of earth abundant raw materials.
Abuabara SG, Arthur Connell, Cao Y, Saygili Y, Ummadisingu A, Teuscher J, Luo J, Pellet N, Giordano F, Zakeeruddin SM, Moser J-E, Freitag M, Hagfeldt A, Grätzel M, Carnie MJ, Christopher Kershaw, Dawn Geatches, Eurig W. Jones, Holliman PJ, James McGettrick, Kakiage K, Leo Furnell, McEwen JJ, Nazeeruddin MK, Pastore M, Peter J. Holliman, Robert Hobbs, Rosie Anthony, Sebastian Metz, Sundari CDD   +18 more
core   +4 more sources

Green synthesized hydroxamic acid administered in high dose disrupts the antioxidant balance in the hepatic and splenic tissues of albino rats

Clinical Phytoscience, 2020
Background Hydroxamic acids are currently being used in diverse biological activities. We investigated the effect of hydroxamic acid, synthesized from Cyperus esculentus seeds, on the antioxidant status of the liver, spleen, and kidney of Wistar rats ...
Chiagoziem A. Otuechere, Adewale Adewuyi, Oluwabukola Bankole   +2 more
doaj   +1 more source

Synthesis of Pyrrolo[1,2-a]pyrimidine Enantiomers via Domino Ring-Closure followed by Retro Diels-Alder Protocol

Molecules, 2017
From 2-aminonorbornene hydroxamic acids, a simple and efficient method for the preparation of pyrrolo[1,2-a]pyrimidine enantiomers is reported. The synthesis is based on domino ring-closure followed by microwave-induced retro Diels-Alder (RDA) protocols,
Beáta Fekete, Márta Palkó, Matti Haukka, Ferenc Fülöp   +3 more
doaj   +1 more source

Interaction of solid organic acids with carbon nanotube field effect transistors [PDF]

, 2006
A series of solid organic acids were used to p-dope carbon nanotubes. The extent of doping is shown to be dependent on the pKa value of the acids. Highly fluorinated carboxylic acids and sulfonic acids are very effective in shifting the threshold voltage
Ali Afzali, Anantram, Avouris, Bradley, Chen, Christian Klinke, Collins, Covington, Derycke, Dukovic, Eberson, Freedman, Fuhrer, Heinze, Kazaoui, Kim, Klinke, Klinke, Mann, Martel, Martel, McBee, O’Connell, Phaedon Avouris, Radosavljevic, Shimauchi, Strano, Tans, Ventura   +28 more
core   +1 more source

Chemical stability of xanthates, dithiophosphinates and hydroxamic acids in aqueous solutions and their environmental implications

Ecotoxicology and Environmental Safety, 2021
Currently there is a wide variety of collectors used in mineral processing, the xanthates being the most used in sulfides flotation. Unfortunately, it is known that xanthates are not stable compounds and their decomposition generates carbon disulfide ...
Martha Araceli Elizondo-Álvarez, Alejandro Uribe-Salas, Simón Bello-Teodoro   +2 more
doaj   +1 more source

Inhibition of histone deacetylase as a treatment for cardiac hypertrophy [PDF]

, 2005
The present invention provides for methods of treating and preventing cardiac hypertrophy. Class II HDACs, which are known to participate in regulation of chromatin structure and gene expression, have been shown to have beneficial effects on cardiac ...
Bristow, Michael R., Long, Carlin, McKinsey, Timothy A., Olson, Eric N.   +3 more
core   +1 more source

Design, synthesis, and biological evaluation of histone deacetylase inhibitor with novel salicylamide zinc binding group

Medicine, 2022
. Introduction:. Histone deacetylases (HDACs) have emerged as important therapeutic targets for various diseases, such as cancer and neurological disorders.
Ji Hyun Kim, MS, Khan Hashim Ali, MS, Yong Jin Oh, PhD, Young Ho Seo, PhD, Chang Chen.   +4 more
doaj   +1 more source

One-Pot Synthesis of Nα-Protected Amino/Peptide O-benzyl Hydroxamates and Acylaminoxy Dipeptides Employing Hydroxamic Acid [PDF]

, 2016
The direct conversion of simple and sterically hindered Nα-protected amino/peptide hydroxamic acids to O-benzyl hydroxamates employing K2CO3, tetrabutylammonium bromide and benzyl bromide is described.
Krishnamurthy, Muniyappa., Sagar, N.R., Sureshbabu, V.V.   +2 more
core   +2 more sources

Histone deacetylase inhibitors induce invasion of human melanoma cells in vitro via differential regulation of N-cadherin expression and RhoA activity [PDF]

, 2016
Background: Histone deacetylase inhibitors (HDACi) exert multiple cytotoxic actions on cancer cells. Currently, different synthetic HDACi are in clinical use or clinical trials; nevertheless, since both pro-invasive and anti-invasive activities have been
Andrade, Ricardo, Arluzea, Jon, Aréchaga, Juan, De Wever, Olivier, Díaz-Núñez, María, Díez-Torre, Alejandro, Silió, Margarita   +6 more
core   +4 more sources