Results 41 to 50 of about 5,129,522 (237)

Evaluation of the properties of complexing agent-collectors of eudialyte flotation [PDF]

Vestnik MGTU, 2015
Acid-based and complexing properties of reagent-collectors (carboxylic and hydroxamic acids, styrylphosphonic acid and dialkyl ether of phosphoric acid) for flotation of zirconium-containing minerals have been studied.
Mitrofanova G.V., Ivanova V.A., Nikitina I.V.   +2 more
doaj  

Green synthesized hydroxamic acid administered in high dose disrupts the antioxidant balance in the hepatic and splenic tissues of albino rats

Clinical Phytoscience, 2020
Background Hydroxamic acids are currently being used in diverse biological activities. We investigated the effect of hydroxamic acid, synthesized from Cyperus esculentus seeds, on the antioxidant status of the liver, spleen, and kidney of Wistar rats ...
Chiagoziem A. Otuechere, Adewale Adewuyi, Oluwabukola Bankole   +2 more
doaj   +1 more source

The Lossen rearrangement from free hydroxamic acids.

Organic and biomolecular chemistry, 2019
The Lossen rearrangement, that allows the conversion of hydroxamic acids into isocyanates, was discovered almost 150 years ago. For more than a century, this transformation was supposed to occur exclusively in the presence of stoichiometric amounts of ...
Mikaël Thomas, Jérôme Alsarraf, N. Araji, Isabelle Tranoy‐Opalinski, B. Renoux, S. Papot   +5 more
semanticscholar   +1 more source

Synthesis of Pyrrolo[1,2-a]pyrimidine Enantiomers via Domino Ring-Closure followed by Retro Diels-Alder Protocol

Molecules, 2017
From 2-aminonorbornene hydroxamic acids, a simple and efficient method for the preparation of pyrrolo[1,2-a]pyrimidine enantiomers is reported. The synthesis is based on domino ring-closure followed by microwave-induced retro Diels-Alder (RDA) protocols,
Beáta Fekete, Márta Palkó, Matti Haukka, Ferenc Fülöp   +3 more
doaj   +1 more source

Hydroxamic Acids Constitute a Novel Class of Autotaxin Inhibitors that Exhibit in Vivo Efficacy in a Pulmonary Fibrosis Model.

Journal of Medicinal Chemistry, 2018
Autotaxin (ATX) catalyzes the hydrolysis of lysophosphatidylcholine (LPC) generating the lipid mediator lysophosphatidic acid (LPA). Both ATX and LPA are involved in various pathological inflammatory conditions, including fibrosis and cancer, and have ...
Aikaterini Nikolaou, I. Ninou, Maroula G. Kokotou, Eleanna Kaffe, A. Afantitis, V. Aidinis, G. Kokotos   +6 more
semanticscholar   +1 more source

Design, synthesis, and biological evaluation of histone deacetylase inhibitor with novel salicylamide zinc binding group

Medicine, 2022
. Introduction:. Histone deacetylases (HDACs) have emerged as important therapeutic targets for various diseases, such as cancer and neurological disorders.
Ji Hyun Kim, MS, Khan Hashim Ali, MS, Yong Jin Oh, PhD, Young Ho Seo, PhD, Chang Chen.   +4 more
doaj   +1 more source

The Involvement of the Mitochondrial Amidoxime Reducing Component (mARC) in the Reductive Metabolism of Hydroxamic Acids

Drug Metabolism And Disposition, 2018
The mitochondrial amidoxime reducing component is a recently discovered molybdenum enzyme in mammals which, in concert with the electron transport proteins cytochrome b5 and NADH cytochrome b5 reductase, catalyzes the reduction of N-oxygenated structures.
Carsten Ginsel, B. Plitzko, Danilo Froriep, D. Stolfa, M. Jung, Christian Kubitza, A. Scheidig, Antje Havemeyer, B. Clement   +8 more
semanticscholar   +1 more source

Cinnamic‐Hydroxamic‐Acid Derivatives Exhibit Antibiotic, Anti‐Biofilm, and Supercoiling Relaxation Properties by Targeting Bacterial Nucleoid‐Associated Protein HU

Advanced Science, EarlyView.
Cinnamic‐hydroxamic‐acid derivatives (CHADs) are identified as novel inhibitors of the bacterial nucleoid‐associated protein HU, exhibiting potent antibacterial, anti‐biofilm (both inhibition and eradication), and DNA relaxation (anti‐supercoiling) activities. Moreover, CHADs demonstrate strong synergistic effects with multiple antibiotics.
Huan Chen, Yingqi Xu, Zhaoping Xiong, Hongliang Wang, Xin Wang, Yue Kang, Zhonglin Wang, Xiaoyan Zeng, Yahui Liu, Yehuan Zheng, Wei Chen, Mengzhe Li, Zhenyue Hu, Chi Xu, Yue Wu, Yawen Wang, Zuyi Yuan, Shuai Yuan, Huadong Liu, Steve Matthews, Nan Qiao, Yan Li, Bing Liu   +22 more
wiley   +1 more source

Insecticidal activities of histone deacetylase inhibitors against a dipteran parasite of sheep, Lucilia cuprina

International Journal for Parasitology: Drugs and Drug Resistance, 2017
Histone deacetylase inhibitors (HDACi) are being investigated for the control of various human parasites. Here we investigate their potential as insecticides for the control of a major ecto-parasite of sheep, the Australian sheep blowfly, Lucilia cuprina.
Neil H. Bagnall, Barney M. Hines, Andrew J. Lucke, Praveer K. Gupta, Robert C. Reid, David P. Fairlie, Andrew C. Kotze   +6 more
doaj   +1 more source

Hydroxamic Acid Derivatives: From Synthetic Strategies to Medicinal Chemistry Applications

ACS Omega, 2021
Since the approval of three hydroxamic acid-based HDAC inhibitors as anticancer drugs, such functional groups acquired even more notoriety in synthetic medicinal chemistry.
A. Citarella, D. Moi, Luca Pinzi, D. Bonanni, G. Rastelli   +4 more
semanticscholar   +1 more source