Results 151 to 160 of about 285 (209)
Detection of Pancreatic Cancer via Specific Metabolite Markers: A Metabolomics Approach
Health Science Reports, Volume 9, Issue 9, September 2026.ABSTRACT Background and Aims Pancreatic ductal adenocarcinoma (PDAC) remains one of the most lethal malignancies worldwide because most patients are diagnosed at advanced stages when curative treatment is no longer feasible. Metabolomics has emerged as a promising strategy for identifying biochemical alterations associated with early tumor development ...
Mohammad Javad Roustaye Gourabi +8 more
wiley +1 more source
Bile acid metabolism and signaling in human and animal health: A One Health perspective
iMetaOmics, Volume 3, Issue 3, September 2026.Bile acids maintain host homeostasis through enterohepatic circulation, microbial transformation, and bile acid receptor signaling, thereby regulating glucose and lipid metabolism, intestinal barrier integrity, and immunity. These effects support human disease intervention and health‐oriented animal production, reducing drug dependence and residue ...
Lei Li +7 more
wiley +1 more source
Journal of the International AIDS Society, Volume 29, Issue 9, September 2026.ABSTRACT Introduction Global awareness to chemsex, a specific form of sexualized psychoactive substance (“chems”) use among gay, bisexual and other men who have sex with men (gbMSM), is increasing. We aimed to assess prevalence, patterns and implications of “chems” use on chemsex‐related outcomes.
Bashkim Jaha +14 more
wiley +1 more source
Journal of Inherited Metabolic Disease, Volume 49, Issue 5, September 2026.ABSTRACT Long‐chain fatty acid oxidation disorders (LC‐FAOD) are rare inherited defects of mitochondrial β‐oxidation that impair energy generation during fasting or metabolic stress. Clinical manifestations range from neonatal hypoketotic hypoglycemia and cardiomyopathy to hepatopathy, recurrent rhabdomyolysis, and chronic myopathy.
Sarah C. Grünert +37 more
wiley +1 more source
Medium Chain Acyl‐CoA Dehydrogenase Deficiency; an Unexpected Cause of Neonatal Ketoacidosis
JIMD Reports, Volume 67, Issue 5, September 2026.ABSTRACT Medium‐chain acyl‐CoA dehydrogenase deficiency (MCADD) classically presents with hypoketotic hypoglycaemia; however, this presentation is now rare following the introduction of newborn screening. While children with MCADD may produce some ketones, severe ketoacidosis has not been previously described.
Nazreen Kamarus Jaman +7 more
wiley +1 more source
Acute gamma hydroxybutyrate toxicity.
The California journal of emergency medicine, 2001 openaire +3 more sources
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Applied Microbiology and Biotechnology, 2009
4-Hydroxybutyrate (4HB) was produced by Aeromonas hydrophila 4AK4, Escherichia coli S17-1, or Pseudomonas putida KT2442 harboring 1,3-propanediol dehydrogenase gene dhaT and aldehyde dehydrogenase gene aldD from P. putida KT2442 which are capable of transforming 1,4-butanediol (1,4-BD) to 4HB.
Lei, Zhang +3 more
openaire +2 more sources
4-Hydroxybutyrate (4HB) was produced by Aeromonas hydrophila 4AK4, Escherichia coli S17-1, or Pseudomonas putida KT2442 harboring 1,3-propanediol dehydrogenase gene dhaT and aldehyde dehydrogenase gene aldD from P. putida KT2442 which are capable of transforming 1,4-butanediol (1,4-BD) to 4HB.
Lei, Zhang +3 more
openaire +2 more sources
Brain and Development, 1994
The clinical findings in six patients from three families with 4-hydroxybutyric aciduria are described. The onset of disease was in early infancy in all cases. All infants presented with severe global delay and severe hypotonia, and all patients had seizure disorder.
Z, Rahbeeni +9 more
openaire +2 more sources
The clinical findings in six patients from three families with 4-hydroxybutyric aciduria are described. The onset of disease was in early infancy in all cases. All infants presented with severe global delay and severe hypotonia, and all patients had seizure disorder.
Z, Rahbeeni +9 more
openaire +2 more sources
International Journal of Neuropharmacology, 1964
Abstract The author presents a general review of the pharmacology of sodium 4-hydroxybutyrate, the principal elements of which are: (a) very low toxicity, and metabolic application; (b) the hypnotic activity, which does not cause a decrease in the intensity of oxidative processes; (c) the potentiating action on anaesthetics and neuroplegics ...
openaire +2 more sources
Abstract The author presents a general review of the pharmacology of sodium 4-hydroxybutyrate, the principal elements of which are: (a) very low toxicity, and metabolic application; (b) the hypnotic activity, which does not cause a decrease in the intensity of oxidative processes; (c) the potentiating action on anaesthetics and neuroplegics ...
openaire +2 more sources
BioEssays, 1984
AbstractRecent work has led to the discovery of six patients with 4‐hydroxybutyric acid‐uria, a severe hereditary human pathology characterized by the accumulation of a compound of known neuropharmacologic activity in body fluids. The enzymatic deficiency has been localized to succinic semialdehyde dehydrogenase, one of two enzymes involved in the ...
openaire +1 more source
AbstractRecent work has led to the discovery of six patients with 4‐hydroxybutyric acid‐uria, a severe hereditary human pathology characterized by the accumulation of a compound of known neuropharmacologic activity in body fluids. The enzymatic deficiency has been localized to succinic semialdehyde dehydrogenase, one of two enzymes involved in the ...
openaire +1 more source