Results 91 to 100 of about 115,105 (360)

Outlook Magazine, Autumn 2017 [PDF]

, 2017
https://digitalcommons.wustl.edu/outlook/1202/thumbnail ...

core   +1 more source

Favipiravir at high doses has potent antiviral activity in SARS-CoV-2−infected hamsters, whereas hydroxychloroquine lacks activity

Proceedings of the National Academy of Sciences of the United States of America, 2020
Significance The previous lack of consensus around the use of hydroxychloroquine for COVID-19 patients underlines the need to thoroughly assess the in vivo efficacy of drugs against SARS-CoV-2.
Suzanne J. F. Kaptein, Sofie Jacobs, Lana Langendries, Laura Seldeslachts, Sebastiaan ter Horst, L. Liesenborghs, Bart Hens, V. Vergote, E. Heylen, Karine Barthelemy, E. Maas, Carolien de Keyzer, Lindsey Bervoets, Jasper Rymenants, Tina Van Buyten, Xin Zhang, R. Abdelnabi, J. Pang, Rachel J. Williams, H. Thibaut, K. Dallmeier, R. Boudewijns, Jens Wouters, P. Augustijns, N. Verougstraete, C. Cawthorne, J. Breuer, C. Solas, B. Weynand, P. Annaert, I. Spriet, G. Vande Velde, J. Neyts, J. Rocha-Pereira, Leen Delang   +34 more
semanticscholar   +1 more source

Nano‐ and Micro‐Sized Solid Materials Used as Antiviral Agents

Advanced Functional Materials, EarlyView.
Due to the rise of viral infections in humans and possible viral outbreaks, the use of nano‐ or micro‐sized materials as antiviral agents is rapidly increasing. This review explores their antiviral properties against RNA and DNA viruses, either as a prevention or a treatment tool, by delving into their mechanisms of action and how to properly assess ...
Orfeas‐Evangelos Plastiras, Imelda Raczkiewicz, Peggy Bouquet, Jean‐Philippe Dacquin, Jeremy Dhainaut, Anne Goffard, Christophe Volkringer   +6 more
wiley   +1 more source

Effect of hydroxychloroquine and azithromycin combination use in COVID-19 patients – An umbrella review

Indian Journal of Community Medicine
Background: Hydroxychloroquine and Azithromycin combination was used rampantly in management of COVID-19 patients in different countries. Present review was conducted to evaluate the efficacy of Hydroxychloroquine and Azithromycin combination compared to
Kaushik Nag, Kaushik Tripura, Anjan Datta, Nabarun Karmakar, Manvi Singh, Meenu Singh, Kusum Singal, Pranita Pradhan   +7 more
doaj   +1 more source

Macular edema might be a rare presentation of hydroxychloroquine-induced retinal toxicity

Taiwan Journal of Ophthalmology, 2017
The aim of this study is to report a rare case of macular edema as a presentation of hydroxychloroquine-related retinal toxicity. We presented a case of a 46-year-old female patient using hydroxychloroquine for underlying rheumatoid arthritis (RA) with ...
Chih-Yao Chang, Shwu-Jiuan Sheu
doaj   +1 more source

Diagnosis and Management of COVID-19 Disease [PDF]

, 2020
SARS-CoV-2 is a novel coronavirus that was identified in late 2019 as the causative agent of COVID-19 (aka coronavirus disease 2019). On March 11, 2020, the World Health Organization (WHO) declared the world-wide outbreak of COVID-19 a pandemic.
Carlos, Graham, Dela Cruz, Charles S., Gross, Jane E., Jamil, Shazia, Mark, Nick, Pasnick, Susan   +5 more
core   +1 more source

Risk Factors for Hydroxychloroquine Retinopathy and Its Subtypes

JAMA Network Open
Key Points Question What factors beyond hydroxychloroquine dose and duration of use are associated with the risk of hydroxychloroquine retinopathy? Findings In this cohort study of 4677 long-term hydroxychloroquine users with masked adjudication of ...
A. Jorge, R. Melles, Michael F. Marmor, Baijun Zhou, Yuqing Zhang, Hyon K Choi   +5 more
semanticscholar   +1 more source

Effect of Early Treatment With Hydroxychloroquine or Lopinavir and Ritonavir on Risk of Hospitalization Among Patients With COVID-19

JAMA Network Open, 2021
Key Points Question Does hydroxychloroquine or lopinavir-ritonavir, administered as a 9-day course, prevent COVID-19–associated hospitalization in patients with COVID-19?
Gilmar Reis, Eduardo Augusto dos Santos Moreira Silva, D. C. Medeiros Silva, L. Thabane, G. Singh, Jay J. H. Park, Jamie I. Forrest, Ofir Harari, Castilho Vitor Quirino dos Santos, Ana Paula Figueiredo Guimarães de Almeida, Adhemar Dias de Figueiredo Neto, L. C. Savassi, A. C. Milagres, Mauro M Teixeira, M. I. Simplicio, L. B. Ribeiro, Rosemary Oliveira, E. Mills   +17 more
semanticscholar   +1 more source

Multiomics Analyses Reveal an Essential Role of Tryptophan in Treatment of csDMARDs in Rheumatoid Arthritis

Advanced Science, EarlyView.
Rheumatoid arthritis is a disease characterized by joint inflammation. Approximately 50% of patients show insufficient response to traditional synthetic disease‐modifying antirheumatic drugs. This study aims to elucidate differential molecular profiles of the mechanisms underlying drug responses through multi‐omics strategy.
Congcong Jian, Jing Zhu, Jianhong Wu, Yan Zhang, Jianghua Chen, Huan Wang, Hengyan Liu, Ke Xu, Jiaxin Huang, Xiaoting Zhu, Yuanli Wei, Shilin Li, Tingting Wang, Xuan Huang, Qinghua Zou, Jie Zhang, Jiang Su, Xinming Du, Yaping Lu, Tianci Zhou, Yingtong Zhou, Minglong Tang, Bin Li, Xue Zhou, Qihao Wei, Qiulong Yan, Fanxin Zeng   +26 more
wiley   +1 more source

Will Hydroxychloroquine Still Be a Game-Changer for COVID-19 by Combining Azithromycin?

Frontiers in Immunology, 2020
Recent small-scale clinical trials have shown promising results in the use of hydroxychloroquine, an FDA approved anti-malaria drug, for the treatment of COVID-19.
Chunfeng Li, Genhong Cheng
doaj   +1 more source