Results 31 to 40 of about 308 (125)
Chemistry &Biodiversity, Volume 23, Issue 10, October 2026.Ligustrum sinense (L. sinense) leaf extract exhibited moderate antioxidant activity (DPPH IC50 = 73.56 ± 2.18 µg/mL) and was evaluated for neuropharmacological effects at 200 and 400 mg/kg using elevated plus maze, open‐field, hole‐cross, and hole‐board tests.
Sowmitro Das +9 more
wiley +1 more source
, 1989 In the present study the neuronal source of adenosine released by K+, morphine and norepinephrine (NE) from the spinal cord was investigated. Intrathecal pretreatment with 5,7-dihydroxytryptamine and 6-hydroxydopamine reduced spinal 5-hydroxytryptamine ...
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Food Science &Nutrition, Volume 14, Issue 10, October 2026.Carica papaya preparations have produced changes in antioxidant, Nrf2‐related, cholinergic, amyloid‐associated, inflammatory, apoptotic, neuronal, and behavioral endpoints in preclinical models. The evidence is model‐ and preparation‐specific, and clinical efficacy has not been established. ABSTRACT Carica papaya (C.
Rakib Hossan +9 more
wiley +1 more source
Studies on the neuroprotective effect of YC-1
, 2007 巴金森氏症是現今最常見的神經退化性疾病之一，在目前的醫療只能治標不能治本，並且對於其致病機轉仍然不清楚的情況下，研發新的治療藥物並研究致病原因是非常必要的。 我們發現YC-1可以減少SH-SY5Y受到MPP+和6-OHDA的損害，SH-SY5Y是神經母細胞瘤的細胞株，具有多巴胺神經的特徵，對MPP+和6-OHDA具有敏感性，而YC-1可以增加sGC對NO的感受性，是一個sGC 活化劑，早先被發現具有抗血小板凝集和使血管平滑肌放鬆的功能，之後又陸續有報告指出它在其他疾病模式下也有不同的效果。
余曉青, Yu, Hsiao-Ching
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Health Care Science, Volume 5, Issue 5, Page 495-513, October 2026.This review elucidates the crosstalk between Parkinson's disease and colorectal cancer, driven by shared genetics (PRKN, PINK1, DJ‐1) involving oxidative stress, cell cycle regulation, and inflammation. It identifies the gut microbiota—via functional amyloids and short‐chain fatty acids (SCFAs)—as a mechanistic bridge, offering insights for dual ...
Jiacheng Ying +6 more
wiley +1 more source
Journal of Extracellular Vesicles, Volume 15, Issue 10, October 2026.The vasculo‐splenic axis during exercise: shear stress triggers the release of medium/large extracellular vesicles from vascular endothelial cells via activation of Piezo1, shuttling Piezo1 to the smooth muscle cells in the splenic capsule; the translocated Piezo1 within the splenic capsule acts as a downstream effector of the α1‐adrenergic receptor ...
Jing Lou +12 more
wiley +1 more source
Fumarate and Its Esters: Physiology, Pathology, Molecular Mechanisms, Diseases, and Therapy
MedComm, Volume 7, Issue 10, October 2026.Fumarate is an endogenous immunometabolite that regulates metabolism, redox homeostasis, and inflammation. Although fumaric acid esters (FAEs) share several molecular targets with fumarate, their distinct physicochemical properties confer unique biological activities and therapeutic applications.
Peng Zhu +6 more
wiley +1 more source
Aging Cell, Volume 25, Issue 10, October 2026.Mitochondrial fission‐fusion imbalance contributes to age‐related cardio‐cerebral diseases like Alzheimer's disease, Parkinson's disease, Cerebral Infarction, Arteriosclerosis, Myocardial Infarction, Cardiac valve disease, Hypertension, and Cardiomyopathy. This review summarizes its regulatory mechanisms and interventions.
Yuyao Yin, Zijian Li
wiley +1 more source
6-Hydroxydopamine and Anticholinergic Drugs [PDF]
Science, 1978 S T, Mason, H C, Fibiger
openaire +2 more sources
Strengths and limitations of morphological and behavioral analyses in detecting dopaminergic deficiency in Caenorhabditis elegans. [PDF]
Neurotoxicology, 2019 Smith LL +5 more
europepmc +1 more source