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Behavioral pharmacology of 6-hydroxydopamine
Life Sciences, 1973Publisher Summary This chapter reviews the behavioral pharmacology of 6-hydroxydopamine. The ability of 6-hydroxydopamine (6-HDA) to produce a specific degeneration of central catecholamine-containing neurons offers a unique opportunity to study the consequences of loss of these neurons on the performance of a conditioned response. The 6-HDA treatment
R.I. Schoenfeld, M.J. Zigmond
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Prevention of 6-hydroxydopamine neurotoxicity
European Journal of Pharmacology, 19751-Phenyl-3-(2-thiazolyl)-2-thiourea (PTTU) prevented the neurotoxic actions of 6-hydroxydopamine on adrenergic nerves in the mouse atrium and iris. This is the first reported 6-hydroxydopamine antagonist that does not act by blocking uptake of catecholamines into nerve terminals. PTTU also prevented the diabetogenic action of alloxan.
G, Cohen +4 more
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Central effects of 6-hydroxydopamine
Physiology & Behavior, 1971Abstract The central effects of 6-hydroxydopamine (6-OHDA) injected intracerebrally in mice and intracisternally in rats have been studied. Mice treated with 100 μg of the drug were sedated and lethargic, with reduced spontaneous activity, for periods of up to 8 days after injection. For a similar period, the response to amphetamine consisted only of
A S, De Carolis +3 more
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6-Hydroxydopamine and Aggression in Cats
Pharmacology Biochemistry and Behavior, 1981The effect of 6-hydroxydopamine (6-OHDA) injected into the cerebral ventricles on behaviour of singly- and group-housed cats was investigated. 6-OHDA in doses of 0.5, 1 and 2 mg was administered every morning for 5 to 8 days. In small doses 6-OHDA in singly- and group-housed cats evoked motor phenomena such as tremor, ataxia, rigidity, weakness and ...
D B, Beleslin +2 more
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Psychopharmacology, 1980
After intracisternal 6-hydroxydopamine (6-OHDA) in mice, brain noradrenaline (NA) and dopamine (DA) are diminished, although the reduction of NA is more pronounced. Intracisternal injection of 6-OHDA in desmethylimipramine (DMI)-pretreated animals strengthens the depletion of DA while NA is partly protected.
V, Fuchs, H, Coper
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After intracisternal 6-hydroxydopamine (6-OHDA) in mice, brain noradrenaline (NA) and dopamine (DA) are diminished, although the reduction of NA is more pronounced. Intracisternal injection of 6-OHDA in desmethylimipramine (DMI)-pretreated animals strengthens the depletion of DA while NA is partly protected.
V, Fuchs, H, Coper
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Effects of 6‐hydroxydopamine and 5‐hydroxydopamine onlthe teleost melanophores innervation
Journal of Fish Biology, 1978Intraperitoneal injections of 6‐OH‐dopamine (80 mg kg−l) promote, in toad fish, killifish, lsummer and winter flounders, a darkening of their colour and loss of capacity to adapt tolthe colour of the background. This condition persisted for three weeks after which thelanimals gradually returned to normal.
L.C.U. Junqueira, L. M. M. Salles
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The 6-Hydroxydopamine model of parkinson’s disease
Neurotoxicity Research, 2007The neurotoxin 6-hydroxydopamine (6-OHDA) continues to constitute a valuable topical tool used chiefly in modeling Parkinson's disease in the rat. The classical method of intracerebral infusion of 6-OHDA involving a massive destruction of nigrostriatal dopaminergic neurons, is largely used to investigate motor and biochemical dysfunctions in Parkinson ...
SIMOLA, NICOLA +2 more
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