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Network analysis of hydroxymethylbilane synthase dynamics

Journal of Molecular Graphics and Modelling, 2020
Hydroxymethylbilane synthase (HMBS) is one of the key enzymes of the heme biosynthetic pathway that catalyzes porphobilinogen to form the linear tetrapyrrole 1-hydroxymethylbilane through four intermediate steps. Mutations in the human HMBS (hHMBS) can lead to acute intermittent porphyria (AIP), a lethal metabolic disorder.
Broto Chakrabarty   +2 more
exaly   +3 more sources

Functional studies of rat hydroxymethylbilane synthase

Bioorganic Chemistry, 2008
The structurally related tetrapyrrolic pigments are a group of natural products that participate in many of the fundamental biosynthetic and catabolic processes of living organisms. Hydroxymethylbilane synthase catalyzes a rate-limiting step for the biosyntheses of tetrapyrrolic natural products.
Nan Li
exaly   +3 more sources

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