Results 21 to 30 of about 1,943,371 (81)

Updated efficacy and safety data from IMbrave150: atezolizumab plus bevacizumab vs. sorafenib for unresectable hepatocellular carcinoma.

Journal of Hepatology, 2021
BACKGROUND & AIMS IMbrave150 demonstrated significantly improved overall survival (OS) and progression-free survival (PFS) with atezolizumab plus bevacizumab vs sorafenib in patients with unresectable hepatocellular carcinoma at the primary analysis ...
A. Cheng, S. Qin, M. Ikeda, P. Galle, M. Ducreux, Tae-You Kim, Ho Yeong Lim, M. Kudo, V. Breder, P. Merle, A. Kaseb, Daneng Li, W. Verret, N. Ma, A. Nicholas, Yifan Wang, Lindong Li, A. Zhu, R. Finn   +18 more
semanticscholar   +1 more source

Lenvatinib plus Pembrolizumab or Everolimus for Advanced Renal Cell Carcinoma.

New England Journal of Medicine, 2021
BACKGROUND Lenvatinib in combination with pembrolizumab or everolimus has activity against advanced renal cell carcinoma. The efficacy of these regimens as compared with that of sunitinib is unclear. METHODS In this phase 3 trial, we randomly assigned (
R. Motzer, B. Alekseev, S. Rha, C. Porta, M. Eto, T. Powles, V. Grünwald, Thomas E. Hutson, E. Kopyltsov, M. Méndez-Vidal, V. Kozlov, A. Alyasova, Sung-Hoo Hong, A. Kapoor, T. Alonso Gordoa, J. Merchan, E. Winquist, P. Maroto, Jeffrey C. Goh, Miso Kim, H. Gurney, V. Patel, A. Peer, G. Procopio, T. Takagi, B. Melichar, F. Rolland, U. de Giorgi, Shirley S. Wong, J. Bedke, M. Schmidinger, C. Dutcus, Alan D. Smith, L. Dutta, K. Mody, R. Perini, D. Xing, T. Choueiri   +37 more
semanticscholar   +1 more source

Pembrolizumab plus chemotherapy versus chemotherapy alone for first-line treatment of advanced oesophageal cancer (KEYNOTE-590): a randomised, placebo-controlled, phase 3 study.

The Lancet, 2021
BACKGROUND First-line therapy for advanced oesophageal cancer is currently limited to fluoropyrimidine plus platinum-based chemotherapy. We aimed to evaluate the antitumour activity of pembrolizumab plus chemotherapy versus chemotherapy alone as first ...
Jong-Mu Sun, L. Shen, M. Shah, P. Enzinger, A. Adenis, T. Doi, T. Kojima, J. Metges, Zhigang Li, Sung-Bae Kim, B. Cho, Wasat Mansoor, Shau-Hsuan Li, P. Sunpaweravong, M. Maqueda, E. Goekkurt, H. Hara, L. Antunes, C. Fountzilas, A. Tsuji, V. C. Oliden, Qi Liu, Sukrut Shah, P. Bhagia, Ken Kato   +24 more
semanticscholar   +1 more source

Selección de distribuciones de probabilidad hidrológica para eventos de lluvia extrema en las regiones de Colombia [PDF]

, 2020
Frequency analysis of extreme events is used to estimate the maximum rainfall associated with different return periods and is used in planning hydraulic structures.
Merlano-Sabalza, Ernesto, Díaz-Vergara, Zaid, Coronado Hernández, Jairo Rafael, Óscar E. Coronado-Hernández, Ernesto Merlano-Sabalza, Zaid Díaz-Vergara, Coronado-Hernández, Oscar E., Coronado Hernández, Óscar Enrique, Coronado-Hernandez, Jairo R., Jairo R. Coronado-Hernández, Coronado Hernández, Oscar E.   +10 more
core   +1 more source

Nivolumab plus Cabozantinib versus Sunitinib for Advanced Renal-Cell Carcinoma

New England Journal of Medicine, 2021
BACKGROUND The efficacy and safety of nivolumab plus cabozantinib as compared with those of sunitinib in the treatment of previously untreated advanced renal-cell carcinoma are not known. METHODS In this phase 3, randomized, open-label trial, we randomly
T. Choueiri, T. Powles, M. Burotto, B. Escudier, M. Bourlon, B. Żurawski, V. O. Oyervides Juarez, J. Hsieh, U. Basso, A. Shah, C. Suarez, A. Hamzaj, Jeffrey C. Goh, C. Barrios, M. Richardet, C. Porta, R. Kowalyszyn, J. Feregrino, J. Zolnierek, D. Pook, E. Kessler, Y. Tomita, R. Mizuno, J. Bedke, Joshua Zhang, M. Maurer, B. Simsek, F. Ejzykowicz, G. Schwab, A. Apolo, R. Motzer   +30 more
semanticscholar   +1 more source

Lenvatinib plus Pembrolizumab for Advanced Endometrial Cancer

New England Journal of Medicine, 2022
BACKGROUND Standard therapy for advanced endometrial cancer after failure of platinum-based chemotherapy remains unclear. METHODS In this phase 3 trial, we randomly assigned, in a 1:1 ratio, patients with advanced endometrial cancer who had previously ...
V. Makker, N. Colombo, A. Casado Herráez, A. Santin, E. Colomba, D. Miller, K. Fujiwara, S. Pignata, S. Baron-Hay, I. Ray-Coquard, R. Shapira-Frommer, K. Ushijima, J. Sakata, K. Yonemori, Y. M. Kim, E. Guerra, U. Şanlı, M. McCormack, Alan Smith, S. Keefe, Steven Bird, L. Dutta, R. Orlowski, D. Lorusso   +23 more
semanticscholar   +1 more source

Overall Survival with Ribociclib plus Letrozole in Advanced Breast Cancer.

New England Journal of Medicine, 2022
BACKGROUND In a previous analysis of this phase 3 trial, first-line ribociclib plus letrozole resulted in significantly longer progression-free survival than letrozole alone among postmenopausal patients with hormone receptor (HR)-positive, human ...
G. Hortobagyi, S. Stemmer, H. Burris, Y. Yap, G. Sonke, L. Hart, M. Campone, K. Petráková, E. Winer, W. Janni, P. Conte, D. Cameron, F. André, C. Arteaga, J. P. Zarate, A. Chakravartty, T. Taran, Fabienne Le Gac, P. Serra, J. O’Shaughnessy   +19 more
semanticscholar   +1 more source

Understanding the drivers of sustainable land expansion using a patch-generating land use simulation (PLUS) model: A case study in Wuhan, China [PDF]

Computers, Environment and Urban Systems, 2020
Cellular Automata (CA) are widely used to model the dynamics within complex land use and land cover (LULC) systems. Past CA model research has focused on improving the technical modeling procedures, and only a few studies have sought to improve our ...
Xun Liang, Qingfeng Guan, K. Clarke, Shishi Liu, Bingyu Wang, Yao Yao   +5 more
semanticscholar   +1 more source

SynergyFinder Plus: Toward Better Interpretation and Annotation of Drug Combination Screening Datasets

Genomics, Proteomics & Bioinformatics, 2022
Combinatorial therapies have been recently proposed to improve the efficacy of anticancer treatment. The SynergyFinder R package is a software used to analyze pre-clinical drug combination datasets.
Shuyu Zheng, Wenyu Wang, Jehad Aldahdooh, A. Malyutina, Tolou Shadbahr, A. Pessia, Jing Tang   +6 more
semanticscholar   +1 more source

Calcul des hydrogrammes de crues et analyse fréquentielle des données hydro-pluviométriques dans le bassin versant de l’Oued Isser (Nord Algérie) [PDF]

, 2021
L’hydrogramme de crue est une information trop importante dans la réalisation des projets pour prévenir les crues, dans le but de la protection des ouvrages et leurs dimensionnements ainsi que pour éviter les risques de catastrophe.
BOUREZGUE, Hakim Syphax, BOUKAMOUM, Thilali   +1 more
core