Results 191 to 200 of about 10,766,583 (291)

Cysteine Peptidases in Antitumor Immunity: Unraveling Antigen‐Presenting Cell Regulation and Therapeutic Potential

iMetaMed, EarlyView.
This review systematically summarizes the central role of cysteine peptidases in modulating antigen‐presenting cell (APC) function and antitumor immune responses, highlighting their critical significance in overcoming tumor immune evasion. Current research has established that cysteine peptidase subtypes, including cathepsins B, S, L, and X, exert ...
Yimao Wu, Xiaoyan Chen, Zichang Chen, Yalun Liang, Gokhan Zengin, Qian Zhang, Wenlong Sun, Meng‐Yao Li   +7 more
wiley   +1 more source

Immune Checkpoint Inhibitors Induce Intestinal Epithelial Injury and a Senescence‐Like Phenotype

iNew Medicine, EarlyView.
ICI treatment promotes the infiltration of activated immune cells into the intestinal mucosa. This inflammatory microenvironment is associated with significant epithelial injury, characterized by the disruption of the epithelial barrier, the depletion of specialized secretory cell lineages, and the induction of a premature senescence phenotype ...
Juan Wang, Shuang Wu, Shuangbiao Wei, Weizhen Xiang, Jianshang Huang, Lei Xiong, Hua Wang, Li Zuo   +7 more
wiley   +1 more source

High-Resolution En Face OCT of the RPE in Geographic Atrophy Captures Patterns Resembling Fundus Autofluorescence. [PDF]

Invest Ophthalmol Vis Sci
Hassan AR, Hwang Y, Ploner SB, Babiker F, Zhao PY, Witkin AJ, Liang MC, Karbole W, Maier A, Fujimoto JG, Waheed NK.   +10 more
europepmc   +1 more source

Enhanced CRISPR‐cas systems for genome editing and molecular diagnostics

Interdisciplinary Medicine, EarlyView.
This review systematically summarizes the major optimization strategies for CRISPR‐Cas systems, focusing on the engineering of Cas proteins, guide RNAs, reporter probes, and the incorporation of chemical additives. The aim is to enhance editing precision and diagnostic capability, thereby expanding the CRISPR system's potential for broader biomedical ...
Sheng Li, Han Li, Bojie Chen, Ling Jiang, Keyu Long, Jiaqi Lang, Xingxiang Pu, Erhu Xiong   +7 more
wiley   +1 more source

Joint Quality-Reliability Analysis of IRS-Assisted Communications in Presence of Inverse Power Lomax Fading Channel. [PDF]

Sensors (Basel)
Gvozdarev AS, Manakhov RY.
europepmc   +1 more source

Small Area Consumption Estimates Combining Survey and Financial Footprints Data

Journal of Applied Econometrics, EarlyView.
ABSTRACT We estimate average equivalised consumption measures across 370 local authority districts in Great Britain, using small‐area estimation methods that combine information from a household budget survey, a much larger survey of local demographics and employment, and area‐level information on bank account outflows and energy consumption.
Peter Levell, Lars Nesheim, Gautam Vyas
wiley   +1 more source

Network completeness enables angstrom-scale transport pathways in polymer membranes. [PDF]

Nat Commun
Lee H, Choi S, Bae TH.
europepmc   +1 more source

A Semi‐Automated Microfluidic Platform Employing Machine Learning Analysis to Study Adhesion Kinetics in Acute Myeloid Leukemia

Microscopy Research and Technique, EarlyView.
We have developed a semi‐automated shear flow platform using bright‐field optics and a machine‐learning analysis algorithm to dissect tumor‐microenvironment interactions. The algorithm quantifies the extent of adhesion at the single‐cell level and delivers consistent results within minutes instead of hours, facilitating high‐throughput analysis ...
Driti Ashok, Dennis Raith, Gabriel Kalweit, Maria Kalweit, Anusha Klett, Justus Duyster, Jonas Bermeitinger, Tanja Nicole Hartmann   +7 more
wiley   +1 more source

Second Law of Thermodynamics and Strain Gradient Theories of Elasticity. [PDF]

Entropy (Basel)
Giorgi C, Morro A.
europepmc   +1 more source

GSK3 Inhibition During Annelid Head Regeneration Results in a Hyper‐Proliferative Blastema and Impaired Differentiation

Journal of Experimental Zoology Part B: Molecular and Developmental Evolution, EarlyView.
A whole‐body regenerative annelid was treated with a GSK3 inhibitor. While posterior regeneration was mostly normal, GSK3 inhibition prevented differentiation of anterior‐specific structures and instead produced a persistent, oversized, hyper‐proliferative blastema. This suggests that GSK3 promotes anterior identity and halts proliferation during axial
James D. Nowotny, Eduardo E. Zattara, Maria Balarezo, Kevin G. Nyberg, Kenna M. Costello, Alexandra E. Bely   +5 more
wiley   +1 more source