Results 91 to 100 of about 456,827 (283)

The role of mind wandering and anxiety in the association between internet addiction and hyperactivity-impulsivity: a serial mediation model

BMC Psychology
Background Hyperactivity-Impulsivity have significant negative effects on adolescents’ academic performance, physical and mental health, and social relationships.
Yan Li, Zheng Zhang, Liping Cui, Yunfei Wang, Huijuan Guo, Jizhi Wang, Jiansong Zhou, Xiaoping Wang   +7 more
doaj   +1 more source

The comparison of dimensions of empathy in children with attention deficit / hyper activity disorder and sluggish cognitive tempo

مجله علوم روانشناختی, 2021
Background: Many studies have reported impaired empathy in children with Attention Deficit Hyperactivity Disorder. But the main issue(question) is whether Between Dimensions of empathy of children with sluggish cognitive Tempo (which are similar in terms
Roghaye Abdolrahimpour, Touraj Hashemi Nosratabad, Sanaz Pourhedayati, Manizhe Maleki   +3 more
doaj  

ADHD : from childhood into adulthood [PDF]

, 2013
This is an overview of the some of the most recent and seminal research done on Attention Deficit Hyperactivity Disorders (ADHD). ADHD is currently one of the most common reasons for referral to child mental health services and still is under-recognised ...
Camilleri, Nigel, Makhoul, Samer
core  

Selenoprotein H Functions as a PPARα Coactivator to Link Selenium Homeostasis to Hepatic Lipid Metabolism and Protect against Steatohepatitis

Advanced Science, EarlyView.
Our study identifies selenium deficiency as a hallmark of MASH pathogenesis. Dietary selenium supplementation enhances hepatic fatty acid oxidation (FAO) and attenuates MASH progression by activating the PPARα pathway via selenoprotein H (SELENOH). This selenium‐SELENOH‐PPARα nexus redefines the functional scope of selenoproteins, moving from redox ...
Yuwei Zhang, Yuchen Wang, Binbin Li, Xin Li, Chenyu Liu, Yanhao Chen, Cheng Tian, Dongmei Wang, Xiaosong Gu, Chunping Jiang, Yuda Wei, Qiurong Ding   +11 more
wiley   +1 more source

SMAD4 Palmitoylation Drives a Metabolic‐Transcriptional Circuit to Promote Tumorigenesis and Confers Radiosensitivity in Pancreatic Cancer

Advanced Science, EarlyView.
This study identifies palmitoylation as a novel regulatory modification of SMAD4, mediated by ZDHHC22/APT2. It activates fatty acid synthesis, creating a self‐reinforcing SMAD4–FASN–palmitate feedback loop that drives pancreatic cancer growth and enhances radiotherapy sensitivity.
Yang Wang, Shan Zhang, Junping Bai, Xiaobing Li, Yi Han, Min Ji, Chongyi Jiang, Xiaobei Ge, Tianyu Yu, Yongying Hou, Jun Zhang, Wangting Li, Yiran Song, Jiaying Cai, Yingqun Zhou, Liwei An, Feng Wang   +16 more
wiley   +1 more source

Attenuation of Novelty-Induced Hyperactivity of Gria1-/- Mice by Cannabidiol and Hippocampal Inhibitory Chemogenetics

Frontiers in Pharmacology, 2019
Gene-targeted mice with deficient AMPA receptor GluA1 subunits (Gria1-/- mice) show robust hyperlocomotion in a novel environment, suggesting them to constitute a model for hyperactivity disorders such as mania, schizophrenia and attention deficit ...
Teemu Aitta-aho, Milica Maksimovic, Kristiina Dahl, Rolf Sprengel, Esa R. Korpi   +4 more
doaj   +1 more source

Locomotor hyperactivity in 14-3-3Zeta KO mice is associated with dopamine transporter dysfunction [PDF]

, 2013
Dopamine (DA) neurotransmission requires a complex series of enzymatic reactions that are tightly linked to catecholamine exocytosis and receptor interactions on pre- and postsynaptic neurons.
A Abi-Dargham, A Aitken, A Breier, A Vina-Vilaseca, AA Williams, AH Wong, B Giros, B Giros, BL Summers, BT Baune, C Itagaki, CA Tamminga, D Berg, D Sulzer, DL Levy, FA Middleton, H Fu, H Jaaro-Peled, H Khoshbouei, H Koike, HC Baxter, J Sun, J Wang, JA English, JA English, JA Lieberman, JA Lieberman, JH Son, JM van Rossum, K Toska, K Toyo-oka, K Toyo-Oka, KL Holton, M Laruelle, M Laruelle, M Miranda, M Rosner, M van den Buuse, M van den Buuse, MS Samuel, O Halskau Jr., P Coyle, PC Hart, PS Cheah, S Leucht, S Sivagnanasundaram, S Sivagnanasundaram, SG Amara, SR Jones, T Ichimura, T Ichimura, WC Drevets, WT Carpenter, Y Jia   +53 more
core   +2 more sources

ZBTB21 Is a Dual Suppressor of Pyroptosis and MHC‐I Antigen Presentation That Promotes Tumor Immune Evasion

Advanced Science, EarlyView.
ZBTB21 is a transcription factor that epigenetically suppresses pyroptosis and MHC‐I antigen presentation, enabling tumor immune evasion. Genetic ablation of ZBTB21 activates pyroptotic cell death and enhances antigen presentation, recruiting CD8+ T cells to overcome immune checkpoint blockade resistance.
Lei Zhao, Linlin Sheng, Jianhao Qiu, Junjie Ma, Kai Jin, Binggong Zhao, Tianrun Miao, Jing Chen, Yehong Li, Zhan Zhang, Dongfeng Sun, Yongmeng Li, Hui Tian   +12 more
wiley   +1 more source

Hyperactivity precedes conduct problems in preschool children: a longitudinal study

BJPsych Open, 2018
BackgroundExternalising problems are among the most common symptoms of mental health problems in preschool children.AimsTo investigate the development of externalising problems in preschool children over time, and the way in which conduct problems are ...
Berit M. Gustafsson, Henrik Danielsson, Mats Granlund, Per A. Gustafsson, Marie Proczkowska   +4 more
doaj   +1 more source

ADHD-associated risk taking is linked to exaggerated views of the benefits of positive outcomes [PDF]

, 2016
Attention deficit and hyperactivity disorder (ADHD) is often assumed to be associated with increased engagement in risk-taking behaviors. The current study sought to understand the mental processes underlying this association using a theory-driven ...
Aloni, Hamutal, Barke, Edmund, Pollak, Yehuda, Shoham, Rachel, Yaniv, Ilan   +4 more
core   +2 more sources