Results 121 to 130 of about 456,827 (283)
Advanced Science, EarlyView.Glucuronolactone (GLU) as a natural metabolite of glucose, increases Lactobacillus amylovorus abundance and luminal IAA level to activate AHR signaling. In addition, GLU itself can directly elevate AHR signaling activity independently of microbiota and IAA.
Chenbin Cui +8 more
wiley +1 more source
PLoS ONE, 2014 Cochlear trauma causes increased spontaneous activity (hyperactivity) to develop in central auditory structures, and this has been suggested as a neural substrate for tinnitus.
Wilhelmina H A M Mulders +3 more
doaj +1 more source
Advanced Science, EarlyView.This study highlights the capacity for tumor suppressor SATB2 to recruit HDAC3 and catalyze histone H3K9 delactylation, thereby repress transcription of the oncogene LCN2. This novel epigenetic‐metabolic axis inhibits the growth and metastasis of non‐small cell lung cancer, delineating a new mechanistic pathway with potential therapeutic relevance ...
Ting Wen +10 more
wiley +1 more source
Transcriptomic and Neuroimaging Decoding of Brain‐Immune Crosstalk in Thyroid Eye Disease
Advanced Science, EarlyView.This study employed an imaging transcriptomics framework integrating resting‐state fMRI with Allen Human Brain Atlas transcriptomic data, coupled with peripheral blood RNA sequencing, to decode brain‐immune crosstalk in thyroid eye disease. Frontal, parietal, subcortical, and brainstem regions were identified as key neuroimmune‐ vulnerable regions ...
Haiyang Zhang +15 more
wiley +1 more source
Advanced Science, EarlyView.Laterally spreading tumors (LSTs) are precancerous colorectal lesions characterized by a flat morphology. This study reveals a mechanochemical pathway through which a soft matrix microenvironment diminishes spatial constraints in intestinal adenomas. This process promotes deficiencies in tight junction proteins, mediated by the mechanoreceptor ADORA2B ...
Jiamin Zhong +21 more
wiley +1 more source
Ferroptosis: The Demise of Cells Through Phospholipid Peroxidation
Advanced Science, EarlyView.The relative abundance of peroxidation‐resistant monounsaturated fatty acids (MUFAs) vs. peroxidation‐sensitive polyunsaturated fatty acids (PUFAs) incorporated into phospholipid (PL) is a key determinant of ferroptosis sensitivity, as the peroxidation of PL PUFA acyl chains (PUFA‐PL) disrupts membrane integrity, causing ferroptotic cell death ...
Shaojie Cui, Jin Ye
wiley +1 more source
Acta Medica Iranica, 2014 This study examines the association of father's and mother's age with the severity of inattention and hyperactivity/impulsivity. Participants are 470 children with attention deficit hyperactivity disorder (ADHD) diagnosed according to DSM-IV diagnostic ...
Ahmad Ghanizadeh
doaj
Gastrointestinal Manifestations in Rubinstein‐Taybi Syndrome
American Journal of Medical Genetics Part A, EarlyView.ABSTRACT Rubinstein–Taybi syndrome is a rare genetic condition associated with a wide range of physical, cognitive, and developmental impairments, yet its gastrointestinal manifestations remain poorly characterized. Case reports and small series suggest a high prevalence of gastroesophageal reflux, constipation, dysphagia, and nutritional compromise ...
Mohamad Abi Nassif +3 more
wiley +1 more source
Revista CEFACPurpose: to investigate the association of symptoms of inattention and hyperactivity with language development and cognitive, environmental, socioeconomic, and quality of life aspects in children with attention-deficit/hyperactivity disorder.
Nárli Machado-Nascimento +2 more
doaj +2 more sources
Child height, health and human capital: evidence using genetic markers [PDF]
Height has long been recognised as associated with better outcomes: the question is whether this association is causal. We use children’s genetic variants as instrumental variables (IV) to deal with possible unobserved confounders and examine the effect ...
Carol Propper +4 more
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