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Current Problems in Pediatrics, 1984
A symptomatic elevation in plasma ammonium concentration, termed hyperammonemia, is associated with numerous congenital and acquired conditions (Table 11). In some cases, such as urea cycle disorders, ammonia is the principal toxin. In other instances, such as portal systemic encephalopathy, it is but one of a number of metabolic disturbances, However,
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A symptomatic elevation in plasma ammonium concentration, termed hyperammonemia, is associated with numerous congenital and acquired conditions (Table 11). In some cases, such as urea cycle disorders, ammonia is the principal toxin. In other instances, such as portal systemic encephalopathy, it is but one of a number of metabolic disturbances, However,
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Archives of Pediatrics & Adolescent Medicine, 1967
AN UNDERSTANDING of the nature of the underlying biochemical disorder in hyperammonemia is essential to a rational approach to therapy of this condition. Three types of hereditary enzyme defect in the biosynthesis of urea have been characterized in recent years (Table 1): arginosuccinic aciduria (reaction 4), citrullinuria (reaction 3), and ...
B, Levin, A, Russell
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AN UNDERSTANDING of the nature of the underlying biochemical disorder in hyperammonemia is essential to a rational approach to therapy of this condition. Three types of hereditary enzyme defect in the biosynthesis of urea have been characterized in recent years (Table 1): arginosuccinic aciduria (reaction 4), citrullinuria (reaction 3), and ...
B, Levin, A, Russell
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Postictal transient hyperammonemia
The American Journal of Emergency Medicine, 2008We report cases of several patients who were sent to our hospital because of seizure attacks. Transient hyperammonemia was noted. Many biochemistry abnormalities, such as prolactin and creatine kinase, may be found after an episode of seizures, but hyperammonemia seems to not have been reported before.
Kuan-Ting, Liu, Chen-San, Su
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Carbamazepine-induced hyperammonemia
American Journal of Health-System Pharmacy, 2009A case of carbamazepine-induced hyperammonemia is presented.A 26-year-old man with bipolar disorder, seizures, and mild mental retardation secondary to a traumatic brain injury began treatment with carbamazepine for aggression and seizure control. After three weeks of carbamazepine therapy, the patient arrived at the emergency department (ED) with ...
Erin N, Adams +2 more
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Pharmacotherapy for hyperammonemia
Expert Opinion on Pharmacotherapy, 2014Hepatic encephalopathy (HE) is a serious neuropsychiatric complication that is seen in patients with liver failure. The pathogenesis of HE is not entirely understood, but several hypotheses have emerged and persisted during the years. Despite the many prevalent hypotheses, most of the existing evidence point to ammonia as the main culprit behind ...
Anna, Hadjihambi +2 more
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Valproate‐induced hyperammonemia
Annals of Neurology, 1982AbstractA patient with carbamyl phosphate synthetase deficiency had four episodes of hyperammonemia, up to 226 μM, associated with valproate (VPA) treatment. These were accompanied by vomiting, lethargy, and coma. A group of epileptic patients receiving VPA remained asymptomatic but had significantly higher mean plasma ammonium levels when compared to ...
M L, Batshaw, S W, Brusilow
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Pediatrics, 1980
Goldberg et al1 described 12 infants with hyperammonemia in association with severe perinatal asphyxia, characterized by low Apgar scores and prolonged resuscitation, in premature, term, and postmature neonates. Ballard and colleagues2 reported five preterm infants with transient hyperammonemia and respiratory distress. We wish to summarize briefly the
Sherida E. Tollefsen +2 more
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Goldberg et al1 described 12 infants with hyperammonemia in association with severe perinatal asphyxia, characterized by low Apgar scores and prolonged resuscitation, in premature, term, and postmature neonates. Ballard and colleagues2 reported five preterm infants with transient hyperammonemia and respiratory distress. We wish to summarize briefly the
Sherida E. Tollefsen +2 more
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Clinical Chemistry and Laboratory Medicine, 2002
Hyperammonemia is mainly found in hepatic encephalopathy and in genetic defects of the urea cycle or other pathways of the intermediary metabolism. Clinically a difference has to be made between chronic moderate hyperammonemia and acutely increased concentrations. Pathogenetic mechanisms of ammonia toxicity to the brain are partly unraveled.
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Hyperammonemia is mainly found in hepatic encephalopathy and in genetic defects of the urea cycle or other pathways of the intermediary metabolism. Clinically a difference has to be made between chronic moderate hyperammonemia and acutely increased concentrations. Pathogenetic mechanisms of ammonia toxicity to the brain are partly unraveled.
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Hyperammonemia in Multiple Myeloma
Acta Haematologica, 1990Two patients with multiple myeloma who appeared to be producing ammonia are reported. Both patients showed hyperammonemia and amino acid disturbances, such as a low Fischer ratio. One patient had Bence Jones protein (lambda) type myeloma and became comatose, but the hyperammonemia and disturbance of consciousness were improved by chemotherapy for the ...
H, Matsuzaki +6 more
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Hyperammonemia: The Silent Killer
Southern Medical Journal, 1993Nitrogen, derived from breakdown of dietary amino acids as ammonia, is normally converted to urea and excreted. Impairment in the conversion process (called the urea cycle) can occur, either as a consequence of primary genetic defects or through secondary suppression of enzyme activity.
D E, Miga, K S, Roth
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