Results 81 to 90 of about 9,482 (191)

Ammonia Metabolism in the Aging Liver: Emerging Mechanistic Insights

Aging Cell, Volume 25, Issue 8, August 2026.
Liver aging may weaken ammonia‐detoxification reserve by disrupting mitochondrial ureagenesis, GS‐mediated scavenging, glutamine metabolism, and metabolic zonation. This emerging framework links impaired nitrogen handling to potential hepatic stress amplification and systemic crosstalk, while highlighting the need for direct validation in physiological
Heng Zhang, Guangyu Liang, Anding Liu
wiley   +1 more source

Clinical Trial: Lemborexant Efficacy and Safety in Liver Cirrhosis—Randomized, Double‐Blind, Crossover Clinical Trial

Alimentary Pharmacology &Therapeutics, Volume 64, Issue 4, Page 458-470, August 2026.
RESTORE is a prospective, double‐blind, placebo‐controlled, crossover trial evaluating Lemborexant in cirrhosis at Cipto Mangunkusumo National Referral Hospital. Both 5 and 10 mg doses reduced PSQI by week 2, with sustained benefits post‐crossover. The 5 mg group improved Stroop Test performance, whereas the 10 mg group had prolonged reaction time ...
Rino Alvani Gani, Pitt Akbar, Irsan Hasan, Andri Sanityoso Sulaiman, Cosmas Rinaldi Adithya Lesmana, Juferdy Kurniawan, Sarah Melissa Panjaitan, Valerie Josephine Dirjayanto   +7 more
wiley   +1 more source

Chronic hyperammonemia alters motor and neurochemical responses to activation of group i metabotropic glutamate receptors in the nucleus accumbens in rats in vivo

Neurobiology of Disease, 2003
Hyperammonemia leads to altered cerebral function and neurological alterations in patients with hepatic encephalopathy. We studied the effects of hyperammonemia in rats on the modulation by group I metabotropic glutamate receptors (mGluR) of motor and ...
Juan-José Canales, Amina Elayadi, Mohammed Errami, Marta Llansola, Omar Cauli, Vicente Felipo   +5 more
doaj   +1 more source

Unveiling Gut Homeostasis Disruption in Sepsis: Towards an Integrated Mechanistic and Translational Roadmap

Cell Proliferation, Volume 59, Issue 8, August 2026.
Elucidating the contribution of gut‐organ axes will provide new insights for developing combined therapeutic strategies against sepsis‐associated multiple organ dysfunction. ABSTRACT Sepsis, a life‐threatening clinical syndrome precipitated by a maladaptive host response to infection, is associated with substantial morbidity and high mortality rates ...
Yichen Bao, Lin Qi, Guijun Zou, Xingpeng Yang, Yizhao Ma, Zhifu Li, Xiaohui Du, Pengyue Zhao   +7 more
wiley   +1 more source

Short‐Term Clinical Effects After Switching From Zinc Acetate Hydrate to Zinc Histidine Hydrate in Patients With Chronic Liver Disease

Hepatology Research, Volume 56, Issue 8, Page 1286-1291, August 2026.
Zinc deficiency is frequently seen in patients with chronic liver disease and is linked to poor appetite and nutritional status. We found that switching to zinc histidine hydrate increased zinc levels within a short period and was associated with improved appetite.
Yoshihito Uchida, Naoto Soma, Shohei Tsuji, Satsuki Ando, Kayoko Sugawara, Masamitsu Nakao, Nobuaki Nakayama, Yukinori Imai, Suguru Mizuno, Satoshi Mochida   +9 more
wiley   +1 more source

Enhanced ammonia tolerance at higher salinity reflects metabolic adjustments in Litopenaeus vannamei postlarvae

Journal of the World Aquaculture Society, Volume 57, Issue 4, August 2026.
Abstract Ammonia, a major by‐product of protein catabolism in shrimp, can rapidly accumulate in high‐density culture systems, particularly under limited water exchange. It is a common toxicant and a key limiting factor in intensive aquaculture, entering through the gills and causing metabolic disruption, reduced growth, and increased mortality. In this
Mehmet Kır, Mustafa Topuz
wiley   +1 more source

Neurofilament Light Chain in Cerebrospinal Fluid and Blood Identifies Patients With Minimal and Overt Hepatic Encephalopathy

Liver International, Volume 46, Issue 8, August 2026.
ABSTRACT Background Minimal hepatic encephalopathy (MHE) is an underdiagnosed complication of liver cirrhosis, associated with progression to overt hepatic encephalopathy (HE). The Portosystemic Hepatic Encephalopathy Score (PHES) is the recommended diagnostic standard, but its use is hindered by resource constraints and limited accuracy. Neurofilament
Elise Jonasson, Lea L. Grønkjær, Birgitte G. Jacobsen, Dorte A. Olsen, Charlotte W. Wernberg, Jens Kuhle, Jonna S. Madsen, Tobias Sejbaek, Mette M. Lauridsen   +8 more
wiley   +1 more source

Fatal hyperammonemia caused by Mycoplasma hominis infection: A rare case report

International Journal of Infectious Diseases
Hyperammonemia, a clinical condition characterized by elevated serum ammonia levels, often leads to altered consciousness and can have severe neurological consequences. It predominantly affects patients with hyperammonemic encephalopathy (HE), urea cycle
Yushi Fan, Lanxin Cao, Tiancha Huang, Chengyang Chen, Hui Shan, Linlin Du, Wei Cui, Gensheng Zhang   +7 more
doaj   +1 more source

Guidelines for acute management of hyperammonemia in the Middle East region

Therapeutics and Clinical Risk Management, 2016
Majid Alfadhel,1,2 Fuad Al Mutairi,1,2 Nawal Makhseed,3 Fatma Al Jasmi,4 Khalid Al-Thihli,5 Emtithal Al-Jishi,6 Moeenaldeen AlSayed,7 Zuhair N Al-Hassnan,7,8 Fathiya Al-Murshedi,5 Johannes Häberle,9 Tawfeg Ben-Omran10 Middle East Hyperammonemia and
Alfadhel M, Al Mutairi F, Makhseed N, Al Jasmi F, Al-Thihli K, Al-Jishi E, AlSayed M, Al-Hassnan ZN, Al-Murshedi F, Häberle J, Ben-Omran T   +10 more
doaj  

Hyperammonemia heightens anesthetic sensitivity in male rats with acute hepatic encephalopathy via affecting brain areas represented by the cerebellum

BMC Anesthesiology
Background Precise anesthesia is essential to ensure perioperative safety in patients with hepatic encephalopathy (HE) due to severe liver injuries. Hyperammonemia has been implicated as a possible trigger for HE.
Sa Wang, Xin-Xin Zhao, Dan Tang, Shi-An Li, Tian-Qi Li, Bing-Xue Peng, Yi-Hao Wang, Sai-Hong Xu, Po Gao, Xue Xue, Ying-Fu Jiao, Yan Zhou, Wei-Feng Yu   +12 more
doaj   +1 more source