Results 51 to 60 of about 415 (137)

Brain Na+,K+-ATPase inhibition induced by arginine administration is prevented by vitamins E and C

, 2003
Hyperargininemia is a metabolic disorder caused by deficiency of arginase activity resulting in tissue accumulation of arginine and neurological dysfunction.
Delwing, Daniela, Tagliari, Bárbara, Wannmacher, Clovis Milton Duval, Wyse, Angela Terezinha de Souza, Bavaresco, Caren Serra, Wajner, Moacir, Lamers, Marcelo Lazzaron, Calcagnotto, Thiago   +7 more
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Lipid nanoparticle-targeted mRNA therapy as a treatment for the inherited metabolic liver disorder arginase deficiency [PDF]

, 2019
Arginase deficiency is caused by biallelic mutations in arginase 1 (ARG1), the final step of the urea cycle, and results biochemically in hyperargininemia and the presence of guanidino compounds, while it is clinically notable for developmental delays ...
Liu, Xiao-Bo, Martini, Paolo G V, Allegri, Gabriella, Zhu, Xuling, Lipshutz, Gerald S, Häberle, Johannes, Cederbaum, Stephen D, Martini, Paolo GV, Truong, Brian, Burke, Kristine E   +9 more
core   +1 more source

Arginine administration decreases cerebral cortex acetylcholinesterase and serum butyrylcholinesterase probably by oxidative stress induction

, 2004
In the present study we investigated the action of vitamins E and C on the inhibition of acetylcholinesterase and butyrylcholinesterase activities provoked by arginine in cerebral cortex and serum of 60-day-old rats.
Delwing, Débora, Wannmacher, Clovis Milton Duval, Wyse, Angela Terezinha de Souza, Wajner, Moacir, Chiarani, Fabria, Stefanello, Francieli Moro   +5 more
core   +1 more source

Arginase-1 deficiency

, 2015
Arginase-1 (ARG1) deficiency is a rare autosomal recessive disorder that affects the liver-based urea cycle, leading to impaired ureagenesis. This genetic disorder is caused by 40+ mutations found fairly uniformly spread throughout the ARG1 gene ...
Sin, Yuan Yan, Baron, Garrett, Schulze, Andreas, Funk, Colin D.   +3 more
core   +1 more source

Research Article pubs.acs.org/synthbio SCHEMA-Designed Variants of Human Arginase I and II Reveal Sequence Elements Important to Stability and Catalysis

, 2014
: Arginases catalyze the divalent cation-dependent hydrolysis of L-arginine to urea and L-ornithine. There is significant interest in using arginase as a therapeutic antineogenic agent against L-arginine auxotrophic tumors and in enzyme replacement ...
Ice Lamb, Lynne Chantranupong, George Georgiou, Blake Fechtel, Everett Stone, R E. Miklos, Frances H. Arnold, All A. Hughes, Andrew D. Ellington, Philip A. Romero, Andreas Krause   +10 more
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Intravenous loading with arginine-hydrochloride and ornithine-aspartate in siblings of two families, presenting a familial neurological syndrome associated with cystinuria.

, 1976
1. Arginine-hydrochloride and ornithine-aspartate solutions have been infused intravenously to children of two families. Three children of the WOL. family are affected with hyperargininemia and hyperammonemia, due to a lack of arginase.
Mardens, Yves Léonce, Strauven, Theo, Clara, R, Terheggen, H   +3 more
core  

Nephron-Specific Deletion of Circadian Clock Gene Bmal1 Alters the Plasma and Renal Metabolome and Impairs Drug Disposition

, 2016
The circadian clock controls a wide variety of metabolic and homeostatic processes in a number of tissues, including the kidney. However, the role of the renal circadian clocks remains largely unknown.
Centeno, G., Sylvain Pradervand, Robert Koesters, Nikolaeva, S., Tokonami, N., Koesters, R., Olivier Bonny, Pradervand, S., Bize, V., Mordasini, D., Dmitri Firsov, Camille Ansermet, Ansermet, C., Marc Maillard, David Mordasini, Hugues Henry, Gabriel Centeno, Vincent Bize, Bonny, O., Svetlana Nikolaeva, Henry, H., Maillard, M., Natsuko Tokonami, Firsov, D., Tokonami N, Bonny O, Centeno G, Mordasini D, Bize V, Pradervand S, Ansermet C, Maillard M, Nikolaeva S, Koesters R, Henry H, Firsov D   +35 more
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Novel ARG1 variants identified in a patient with arginase 1 deficiency. [PDF]

Hum Genome Var, 2021
Yokoi K, Nakajima Y, Yasui T, Yoshino M, Yoshikawa T, Kurahashi H, Ito T.   +6 more
europepmc   +1 more source

Human arginase 1, a Jack of all trades? [PDF]

3 Biotech, 2022
Anakha J, Kawathe PS, Datta S, Jawalekar SS, Banerjee UC, Pande AH.   +5 more
europepmc   +1 more source

Doenças hereditárias do metabolismo: importância de um diagnóstico precoce para a criança e para a família [PDF]

, 2011
RESUMO: O sucesso do rastreio neonatal da fenilcetonúria nas décadas de 70/80, veio permitir a partir da década de 90, com o recurso à espectrometria de massa em tandem (MS/MS), a pesquisa de um grande número de doenças hereditárias do metabolismo (DHM)
Martins, Esmeralda
core