Results 91 to 100 of about 65,895 (252)

Multiscale Cell–Cell Interactive Spatial Transcriptomics Analysis

Advanced Science, EarlyView.
In this study, we present the MultiScale Cell‐Cell Interactive Spatial Transcriptomics Analysis method, which unites the strengths of spatially resolved deep learning techniques with a topological representation of multi‐scale cell‐cell similarity relations.
Sean Cottrell, Guo‐Wei Wei
wiley   +1 more source

Uric Acid Functions as an Endogenous Modulator of Microglial Function and Amyloid Clearance in Alzheimer's Disease

Advanced Science, EarlyView.
Higher serum UA levels are associated with reduced AD risk in epidemiological studies. UA enhances microglial phagocytic capacity primarily by restoring CD36 and TREM2 receptor recycling that is impaired by Aβ exposure. Therapeutically, UA supplementation improves cognitive function and reduces neuropathology in AD mouse model by enhancing microglial ...
De Xie, Qiuyang Zheng, Jiaming Lv, Qian Zhang, Zhiwei Cui, Shuai Huang, Wei Yu, Binyang Chen, Wanling Que, Shanpan Fu, Yuemei Xi, Jiayu Chen, Xueling Ye, Shuyi Chen, Hairong Zhao, Tetsuya Yamamoto, Hidenori Koyama, Xin Wang, Jidong Cheng   +18 more
wiley   +1 more source

The Smale Conjecture for Hyperbolic 3-Manifolds: Isom (M3) ≃ Diff (M3) [PDF]

, 2001
David Gabai
openalex   +1 more source

Unambiguous Quantum State Discrimination in a PT$\mathcal {PT}$‐Symmetric System of a Single Trapped Ion

Advanced Science, EarlyView.
An unambiguous quantum state discrimination for two nonorthogonal states is demonstrated using a single ion. By implementing a non‐Hermitian Hamiltonian with parity‐time‐reversal (PT) symmetry, two candidate states evolve with different speed and become orthogonal at specific time, hence can be discriminated unambiguously. Experiments are performed for
Chenhao Zhu, Tingting Shi, Liangyu Ding, Zhiyue Zheng, Xiang Zhang, Wei Zhang   +5 more
wiley   +1 more source

Self-Bumping of Deformation Spaces of Hyperbolic 3-Manifolds [PDF]

, 2001
John Holt
openalex   +1 more source

Mechanical Stretch‐Induced Interlayer Coordination between MMP2 and COL17A1 Exacerbates Regenerative Exhaustion in Skin

Advanced Science, EarlyView.
Regeneration reaches a hidden limit under mechanical stretch. Prolonged tension alters dermal–epidermal communication, exhausting epidermal stem cells via MMP2–COL17A1 signaling. MMP2 inhibition by Marimastat preserves adhesion and regenerative capacity, offering a potential strategy to overcome the inherent boundaries of skin expansion.
Yidan Sun, Qili Qian, Luwen Xu, Bowen Gao, Ting Li, Yin Li, Jiayi Zheng, Qiaoyu Fu, Xi Cheng, Nuo Chen, Sijia Wang, Liang Zhang, Caiyue Liu, Qingfeng Li   +13 more
wiley   +1 more source

High‐Throughput Strategies for Streamlining Lipid Nanoparticle Development Pipeline

Advanced Science, EarlyView.
This review highlights emerging state‐of‐the‐art high‐throughput strategies for optimising lipid nanoparticle formulation. By integrating combinatorial design, characterization, in vitro/in vivo screening, automation, and machine learning into a closed‐loop framework, it provides a roadmap to streamline discovery and accelerate the translation of ...
Lois Lam, Stephanie Watson, Yogambha Ramaswamy, Gurvinder Singh   +3 more
wiley   +1 more source

Deep Learning‐Assisted Fingerprint‐Inspired Flexible Pressure Sensor for Tension Monitoring in Carbon Fiber Production

Advanced Science, EarlyView.
A fingerprint‐inspired piezoresistive sensor is developed for real‐time tension monitoring of wide‐width carbon fiber bundles. Fabricated by laser engraving, it shows high sensitivity, broad range, and durability under high‐temperature conditions. Integrated with a CNN achieving 96% anomaly classification accuracy, the system provides a practical ...
Xiaohua Wu, Xiangbao Huang, Yuxuan Liang, Longsheng Lu, Shu Yang, Jiayue Liao, Hanxian Chen, Feilong Liu, Yilin Zhong, Qinghua Liang, Yingxi Xie   +10 more
wiley   +1 more source

Comprehensive Measurement of Inter‐Individual Variation in DNA Repair Capacity in Healthy Individuals

Advanced Science, EarlyView.
Susceptibility to the health effects of DNA damage depends on a person's ability to repair DNA damage, but DNA repair has been difficult to measure in populations. A functional assay called FM‐HCR is used to measure DNA repair in 6 major pathways across 56 individuals.
Ting Zhai, Patrizia Mazzucato, Catherine Ricciardi, David C. Christiani, Liming Liang, Leona D. Samson, Isaac A. Chaim, Zachary D. Nagel   +7 more
wiley   +1 more source

On strong convergence of hyperbolic 3-cone-manifolds whose singular sets have uniformly thick tubular neighborhoods [PDF]

, 2001
Michihiko Fujii
openalex   +1 more source