Results 151 to 160 of about 379,230 (325)

Uric Acid Functions as an Endogenous Modulator of Microglial Function and Amyloid Clearance in Alzheimer's Disease

open access: yesAdvanced Science, EarlyView.
Higher serum UA levels are associated with reduced AD risk in epidemiological studies. UA enhances microglial phagocytic capacity primarily by restoring CD36 and TREM2 receptor recycling that is impaired by Aβ exposure. Therapeutically, UA supplementation improves cognitive function and reduces neuropathology in AD mouse model by enhancing microglial ...
De Xie   +18 more
wiley   +1 more source

Unambiguous Quantum State Discrimination in a PT$\mathcal {PT}$‐Symmetric System of a Single Trapped Ion

open access: yesAdvanced Science, EarlyView.
An unambiguous quantum state discrimination for two nonorthogonal states is demonstrated using a single ion. By implementing a non‐Hermitian Hamiltonian with parity‐time‐reversal (PT) symmetry, two candidate states evolve with different speed and become orthogonal at specific time, hence can be discriminated unambiguously. Experiments are performed for
Chenhao Zhu   +5 more
wiley   +1 more source

Mechanical Stretch‐Induced Interlayer Coordination between MMP2 and COL17A1 Exacerbates Regenerative Exhaustion in Skin

open access: yesAdvanced Science, EarlyView.
Regeneration reaches a hidden limit under mechanical stretch. Prolonged tension alters dermal–epidermal communication, exhausting epidermal stem cells via MMP2–COL17A1 signaling. MMP2 inhibition by Marimastat preserves adhesion and regenerative capacity, offering a potential strategy to overcome the inherent boundaries of skin expansion.
Yidan Sun   +13 more
wiley   +1 more source

Cauchy Problem for a Darboux Integrable Wave Map System and Equations of Lie Type

open access: yesSymmetry, Integrability and Geometry: Methods and Applications, 2013
The Cauchy problem for harmonic maps from Minkowski space with its standard flat metric to a certain non-constant curvature Lorentzian 2-metric is studied.
Peter J. Vassiliou
doaj   +1 more source

High‐Throughput Strategies for Streamlining Lipid Nanoparticle Development Pipeline

open access: yesAdvanced Science, EarlyView.
This review highlights emerging state‐of‐the‐art high‐throughput strategies for optimising lipid nanoparticle formulation. By integrating combinatorial design, characterization, in vitro/in vivo screening, automation, and machine learning into a closed‐loop framework, it provides a roadmap to streamline discovery and accelerate the translation of ...
Lois Lam   +3 more
wiley   +1 more source

Deep Learning‐Assisted Fingerprint‐Inspired Flexible Pressure Sensor for Tension Monitoring in Carbon Fiber Production

open access: yesAdvanced Science, EarlyView.
A fingerprint‐inspired piezoresistive sensor is developed for real‐time tension monitoring of wide‐width carbon fiber bundles. Fabricated by laser engraving, it shows high sensitivity, broad range, and durability under high‐temperature conditions. Integrated with a CNN achieving 96% anomaly classification accuracy, the system provides a practical ...
Xiaohua Wu   +10 more
wiley   +1 more source

A canonical form for the isoperimetric inequality on manifolds of conformally hyperbolic type [PDF]

open access: green, 1999
Владимир Антонович Зорич   +1 more
openalex   +1 more source

Comprehensive Measurement of Inter‐Individual Variation in DNA Repair Capacity in Healthy Individuals

open access: yesAdvanced Science, EarlyView.
Susceptibility to the health effects of DNA damage depends on a person's ability to repair DNA damage, but DNA repair has been difficult to measure in populations. A functional assay called FM‐HCR is used to measure DNA repair in 6 major pathways across 56 individuals.
Ting Zhai   +7 more
wiley   +1 more source

Highly Efficient Current‐Induced Torques Originating from Topological Surface States in Sb2Te3

open access: yesAdvanced Electronic Materials, EarlyView.
This work explores Sb2Te3 topological insulator thin films as high‐efficiency materials for spin‐charge conversion in spintronics. Grown via MOCVD on 4‐inch wafers, these films enable scalable device fabrication. Magnetoresistance measurements reveal exceptional charge‐to‐spin conversion performance.
Matteo Fettizio   +3 more
wiley   +1 more source

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