Results 241 to 250 of about 32,373 (309)

Membrane Fusion‐Mediated Cytosolic Delivery of Threose Nucleic Acids via Homotypic Nanoparticles Overcomes Drug Resistance in Triple‐Negative Breast Cancer

Advanced Science, EarlyView.
This study introduces a biomimetic “nanofusion” platform that integrates the biostability of threose nucleic acids (TNA) with homotypic cell‐membrane cloaking to combat drug‐resistant TNBC. By leveraging a non‐canonical membrane‐fusion pathway for direct cytosolic delivery, the platform bypasses endosomal sequestration. To achieve potent AKT2 silencing
Wei Zheng, Tristan Juin Han Chang, Xinchao Li, Zhongqi Zhou, Chung Tin, Kenward Vong, Pierre Karam, Pik Kwan Lo   +7 more
wiley   +1 more source

Soliton dynamics in the stochastic nonlinear Schrödinger equation with self-phase modulation and multiplicative white noise. [PDF]

Sci Rep
Shehab MF, Ahmed HM, Hussein HH.
europepmc   +1 more source

SPADE: A Deep Learning Framework for Spatial Mapping and Quantitative Cell–Cell Interaction Inference

Advanced Science, EarlyView.
SPADE integrates spatial transcriptomics with single‐cell RNA sequencing by using cell–cell communications (CCC) as a guide for spatial mapping. It improves cell‐type localization, enhances sparse gene‐expression signals, and reveals CCC programs at single‐spot resolution.
Xinyi Li, Ning Zhang, Zijie Jin
wiley   +1 more source

Hyperbolic localized plasmons and twist-induced chirality in an anisotropic 2D material. [PDF]

Nat Commun
Li Y, Shi X, Zhang Y, Liu YE, Yang H, Lyu G, Matsuo Y, Hu X, Gong Q, Misawa H.   +9 more
europepmc   +1 more source

A Single‐Cell Transcriptomic Atlas of the Ovine Rumen Microbiome Characterizes Lineage‐Specific Metabolic Shifts Associated with Host Heat Tolerance

Advanced Science, EarlyView.
An optimized single‐cell transcriptomic framework profiles over 60 000 cells to map the ovine rumen microbiome, partitioning the ecosystem into seven cross‐species functional clusters. In heat‐resistant hosts, a lineage‐specific metabolic shift in Anaerovibrio lipolyticus toward a highly glycolytic phenotype contributes to a “nutritional sparing ...
Sanbao Zhang, Qinyang Jiang, Junjie Ma, Jianwei Zou, Fan Wang, Feifei Lv, Yanna Huang, Yongcheng Wang, Ziye Xu   +8 more
wiley   +1 more source

Realizing Landau levels with open equifrequency contours around band singularities. [PDF]

Nat Commun
Lu C, You O, Zheng Y, Ma S, Yang Q, Chan HC, Wang Z, Ma W, Liu YC, Zhang S.   +9 more
europepmc   +1 more source

Interacting Parallel Fluidic Hysterons

Advanced Science, EarlyView.
The parallel coupling of fluidic hysterons is introduced, establishing advanced functionalities in inflatable soft systems. A pressure–volume framework reveals how preset volumes Δv∗${\Delta }v^*$ tune nonlinear interactions between hysterons and actuation sequences without changing architecture. Experiments validate the predictions, opening new routes
Katrien Stinissen, Franco Nicolas Piñan Basualdo, Benjamin Gorissen   +2 more
wiley   +1 more source

A novel Fibonacci sequence-based motion profile. [PDF]

Sci Prog
Yao WS, Tseng YC, Hu JH.
europepmc   +1 more source

Physics‐Informed Neural Network‐Enabled Forward Prediction and Inverse Design of Ring Origami

Advanced Science, EarlyView.
This work presents a KRT‐PINN framework that integrates Kirchhoff rod theory with physics‐informed neural networks for the forward prediction and inverse design of ring origami consisting of closed‐loop rods. The framework predicts stable states of segmented rings with prescribed natural‐curvature profiles and determines the natural‐curvature profiles ...
Luyuan Ning, Lu Lu, Sophie Leanza, Ruike Renee Zhao   +3 more
wiley   +1 more source

A note on integrated local energy decay estimates for spherically symmetric black hole spacetimes. [PDF]

Math Ann
Holzegel G, Mavrogiannis G, Ruiz RV.
europepmc   +1 more source