Results 201 to 210 of about 5,110,179 (281)

LAMC2+ Epithelial Cells Drive Bladder Cancer Progression and Predict Immunotherapy Response via SERPINB3/STAT3/CD44 Axis

Cancer Science, Volume 117, Issue 11, Page 3071-3085, November 2026.
This study identified LAMC2+ epithelial cells through single‐cell sequencing and found that high expression of LAMC2 is associated with the malignant progression of bladder cancer. HdWGCNA and transcriptome sequencing revealed the SerpinB3/STAT3/CD44 axis. Diosmetin was selected as a potential LAMC2 inhibitor.
Yutong Chen, Yunzhong Jiang, Zezhong Yang, Minxuan Jing, Wentai Wu, Jiale He, Lu Wang, Minghai Ma, Yaodong Zhang, Min Wang, Jianpeng Li, Yuanchun Pu, Bingliang He, Yanjia Liu, Kaibo Mi, Hang Liu, Mengzhao Zhang, Jinhai Fan   +17 more
wiley   +1 more source

Quantitative proteomics reveals coordinated changes in the proteome during replicative senescence. [PDF]

Nat Commun
Da Silva Fernandes N, Kielisch F, Fulzele A, Karunanithi S, Gräf JF, Chen JX, Behl C, Ulrich HD, Beli P.   +8 more
europepmc   +1 more source

Genetic Novelty and Short‐Term Evolutionary Dynamics in Drosophila yakuba mayottensis

Molecular Ecology, Volume 35, Issue 21, November 2026.
ABSTRACT Understanding how genetic novelty arises and contributes to population divergence is central to evolutionary biology. On short evolutionary timescales, the relative roles of new mutations and standing variation remain underexplored among structural variation. Here, we compare the contributions of chromosomal rearrangements, tandem duplications
Brandon A. Turner, James E. Titus‐McQuillan, Amir Yassin, Rebekah L. Rogers   +3 more
wiley   +1 more source

Benchmarking methods for inferring single-cell transcription factor activity using large-scale perturbation sequencing data. [PDF]

Brief Bioinform
Zhu Y, Han D, Wang Z.
europepmc   +1 more source

CRISPR/Cas9‐Mediated Knockout of LbSP1 and LbSP5G1 Reveals Efficient Customization of Shoot Architecture in Black Goji Berry

Plant Biotechnology Journal, Volume 24, Issue 11, Page 5868-5890, November 2026.
ABSTRACT Goji is recognized as a nutritionally rich superfruit with medicinal and industrial importance. However, its inherently indeterminate growth habit causes asynchronous flowering and uneven fruit ripening, resulting in harvesting inefficiency with high labour costs and low fruit yield.
Fazal Rehman, Huanfang Liu, Yun Ma, Shaohua Zeng, Yan Wu, Yuan Zong, Chao Yang, Ying Wang   +7 more
wiley   +1 more source

Stochastic expansion of radionuclide inhalation dosimetry for consequence management application: uncertainty and sensitivity analysis in the ICRP 130 human respiratory tract model. [PDF]

J Radiol Prot
Mate-Kole EM, Howard SC, Golden AP, Hooper DA, Wilson BA, Dewji SA.   +5 more
europepmc   +1 more source

Unravelling Mechanisms of Acquired Drought Tolerance by Priming in Tomato Using Integrative Multi‐Omics Phenotypic Analysis

Plant Biotechnology Journal, Volume 24, Issue 11, Page 5946-5966, November 2026.
ABSTRACT The escalating frequency and intensity of recent droughts threaten global crop production and food security. Although drought priming is crucial for plant drought resilience, the mechanisms imparting drought stress memory remain poorly understood, especially in crops such as tomato. This study elucidates the mechanisms of drought stress memory
Rong Zhou, Yankai Li, Ge Wang, Hong Chen, Xiaqing Yu, Yinlei Wang, Xuedong Yang, Zhen Lyu, Trupti Joshi, Xiaoming Song, Carl‐Otto Ottosen, Ian Charles Dodd, Ron Mittler, Fangling Jiang, Zhen Wu   +14 more
wiley   +1 more source

Regulation of mRNA poly(A) tail length governs mammalian body plan formation in gastruloids. [PDF]

Nat Commun
Taborsky D, Valdivia-Francia F, Serrano P, Muzumdar S, Ranjbar N, Llop-Grau L, Tellez G, Gjonlleshaj P, Duré C, Renz PF, Weber R, Yigit M, Ghoshdastider U, Mironov A, Hyams K, Vianello S, Zavolan M, Bar-Nur O, Lutolf MP, Sendoel A.   +19 more
europepmc   +1 more source

Single‐nucleus transcriptomics reveals transcriptional dynamics underlying maize ligule development

The Plant Journal, Volume 128, Issue 3, November 2026.
SUMMARY The maize ligule arises from the preligule band (PLB) at the leaf blade‐sheath boundary and provides a tractable system for investigating how boundary‐associated positional cues direct local cell‐fate specification and tissue outgrowth. Although key genes involved in ligule development have been identified and cell‐resolved profiles are ...
Fang Wei, Mingzhang Xia, David W. Galbraith, Jinling Huang, Chun‐Peng Song, Jinjing Pan, Xuefei Yang, Guiling Sun   +7 more
wiley   +1 more source