Results 241 to 250 of about 107,962 (311)

Unveiling a BRAF Signature Proficient in Accurately Capturing Oncogenic Activity and Guiding Prognostic Prediction Across Multiple Cancers

open access: yesMedComm, Volume 7, Issue 2, February 2026.
The BRAF25 meta‐signature effectively captures BRAF‐driven oncogenic activity. By enabling precise patient stratification with distinct mutation profiles, BRAF25 identifies BRAF‐active tumor subtypes and provides superior prognostic value compared with mutation status alone.
Kaidi Yang   +7 more
wiley   +1 more source

Spectral Parameter Power Series Representation for Regular Solutions of the Radial Dirac System

open access: yesMathematical Methods in the Applied Sciences, Volume 49, Issue 3, Page 2098-2113, February 2026.
ABSTRACT A spectral parameter power series (SPPS) representation for the regular solution of the radial Dirac system with complex coefficients is obtained, as well as a SPPS representation for the (entire) characteristic function of the corresponding spectral problem on a finite interval. Based on the SPPS representation, a numerical method for solving
Emmanuel Roque, Sergii M. Torba
wiley   +1 more source

A role for the cholinergic neuron circadian clock in RNA metabolism and mediating neurodegeneration. [PDF]

open access: yesLife Sci Alliance
Tam SB   +7 more
europepmc   +1 more source

RCC1 Domain‐Containing Protein 1 Promotes Colon Cancer Malignant Progression by Activating Autophagy‐Dependent WNT5A Secretion in Cancer‐Associated Fibroblasts

open access: yesJournal of the Royal Society of New Zealand, Volume 56, Issue 1, February 2026.
RCCD1 is upregulated in colon cancer and cancer‐associated fibroblasts (CAFs). In CAFs, RCCD1 overexpression activates AMPK/mTOR/ULK1 signaling, enhancing autophagy. This stimulates autophagic secretion of WNT5A. WNT5A then activates the nonclassical Wnt/CaMKII/ERK pathway in tumor cells, promoting epithelial‐mesenchymal transition (EMT), proliferation,
Chao Liu   +3 more
wiley   +1 more source

The Role of the Gut Microbiome in the Complex Network of Frailty Syndrome and Associated Comorbidities in Aging

open access: yesAging Cell, Volume 25, Issue 2, February 2026.
This study analyzed gut microbiota in older adults with and without Frailty Syndrome by 16S rRNA gene sequencing and metagenomics. Frailty was associated with altered microbial composition, metabolic functions, and increased antimicrobial resistance, whereas non‐frail individuals showed healthier profiles.
Ana Barberá   +5 more
wiley   +1 more source

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